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LOWERCASEGUY

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Posts posted by LOWERCASEGUY

  1. On 3/27/2024 at 2:17 PM, stoner said:

     

    i guess this might also depend on who you know.  🙂

     

    Correct, but it shouldn't be that way.  

     

    I spent a lot of time sampling producers via trial and error testing and it took awhile to find the right people.  

     

    Unfortunately someone coming to Thailand on a 10 day holiday is not in a position to do that.  

     

    If it's medicinal, it should be of medicinal quality.  You don't buy aspirin and have to wonder if there's really aspirin in there.  

    • Like 1
  2. 9 minutes ago, BritManToo said:

    As far as I can see, there's no way to know if you're buying or using CBD, but I can see what I'm buying with unprocessed cannabis.

    Like everything in Thailand, CBD extracts appear mostly fake

     

    You can buy CBD flower and flower can be tested in those same Purpl and Gemmacert testers for CBD content.  

     

    Agree that most CBD extracts are fake.  Then again, about a year ago, most THC extracts you could find in Thailand were fake too.  You had to be really selective who you purchased from because there was zero consistency out in the marketplace.  

  3. 7 minutes ago, SamuiGrower said:


    A lovely review of writing style.

     

    Perhaps you should read the white paper and not the journalists synopsis. 

     

    More information: Andrew Moore et al, Cannabidiol (CBD) Products for Pain: Ineffective, Expensive, and With Potential Harms, The Journal of Pain (2023). DOI: 10.1016/j.jpain.2023.10.009

    Journal information: Journal of Pain 
     

     

    I did.  But my point still stands on the article.  🙂

  4. 21 minutes ago, SamuiGrower said:

    I have attached some posts below, I  have made previously, as well  some links (papers) relating to CBD in pain studies. I am a proponent of CBD in concert with the other cannabinoids (this, by the way, is the REAL entourage effect) and have realized efficacy is binary: it either works for YOU or it does not. It does not work for all. If it did, it would not be the subject of discussion, the headline would read: CBD is a conclusive sleep aid/pain reliever.

     

    I think part of the problem is that way too many people make promises about cannabis that just aren't realistic.  Too many stoner-types who only want to hear good things about weed and if you mention any negatives, they call it drug war propaganda.  

     

    It's that old pendulum swinging to the extremes.  We had 70 or so years of governments lying to us about the harms of cannabis and now we have dudes with ponytails and tiedyed t-shirts saying weed cures cancer.  

     

    I take CBD fairly regularly.  It doesn't have any profounds effects but I do feel a little less stressed out when I take it.  Then again, I feel the same if I'm regularly smoking weed.  Even when I'm not high, things just feel less stressful.  

     

     

    • Like 2
  5. Kind of a crap story.  You can tell by the writing style that either the author started with a conclusion or the researcher he's talking to has more to gain from phrama than natural remedies (or both).  

     

    Quote

    CBD (short for cannabidiol) is one of many chemicals found naturally in the cannabis plant. It's a popular alternative medicine to treat pain 

     

    So, right off the bat, this isn't worded well.  

     

    It is written in a way that seems as if CBD is used exclusively for pain mangement.  That is not the case.  

     

    Pain is one of several things CBD is used for.  And it is known to treat certain types of pain more effectively than others.  For instance, many people report reduced neuropathic pain for certain specific conditions.  You can't just rub some CBD on a broken bone and feel better.  

     

    What CBD is more popularly used for is anxiety and depression.  This is why CBD is often marketed for helping calm people and reduce stress.  

     

    It has also shown promise in helping people undergoing chemo to keep food down and increase appetite.  Other evidence seems to indicate that it can reduce seizures and other neurological conditions (due to the way it buffers nerve cells from damage).  


     

    Quote

    "It's touted as a cure for all pain, but there's a complete lack of quality evidence that it has any positive effects."

     

    But it's not touted as a cure all for pain.  The researchers created a strawman argument.  

     

    Quote

    "It's almost as if chronic pain patients don't matter and that we're happy for people to trade on hope and despair."

     

    He's either being a tad dramatic or he has a financial interest in CBD not being a good pain alternative.  

     

    Wait, took a moment to look this guy up and . . . 

     

    Quote

    Orion developed the software in close collaboration with Professor Christopher Eccleston, a pain specialist from the University of Bath, and technology group Healthware.

     

    So, he's working on VR pain relief.  

     

    Let's look at his findings with this in mind.  

     

    Quote

    CBD products sold directly to consumers contain varying amounts of CBD, from none to much more than advertised.

     

    Well known fact that could be handled by regulating that what's on the outside of the bottle has to be on the inside of the bottle. 

     

    Quote

    CBD products sold directly to consumers may contain chemicals other than CBD, some of which may be harmful and some illegal in some jurisdictions. Such chemicals include THC (tetrahydrocannabinol), the main psychoactive component of the cannabis plant.

     

    I can assure you that every CBD product sold commercially today contins chemicals other than CBD since nearly all CBD products are suspended in another substance like coconut oil.  

     

    This is like saying, my research indicates that cars are not made entirely of metal.  

     

    And buying CBD that doesn't have THC usually means that the CBD is synthetic or that the CBD has been lab produced (isolate) which eliminates the terpenes and other cannabinoids that provide the entourage effect.  

     

    Bottom line is that the best CBD products are full spectrum, meaning they're extracted from a cannabis plant without leaving out the trace amounts of THC and other cannabinoids.  That's why most CBD has warnings on it that it contains less than 0.2% THC.  

     

    But he does have a point that most of the stuff you see advertised online is junk.  That's because it's cheaper to fill a bottle with coconut oil and tell people it's CBD than actually put CBD in the bottle, and there's nobody from the government checking.  

     

    Quote

    Of the 16 randomized controlled trials that have explored the link between pain and pharmaceutical-grade CBD, 15 have shown no positive results, with CBD being no better than placebo at relieving pain.

     

    Too much to dig into but I've skimmed the paper they submitted to the Journal of Pain and I would say this is anything but conclusive.  

     

    For instance, they claimed they couldn't find any studies that supported the claim that CBD is effective against pain.  It took me all of 3 seconds to find this paper.

     

    Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A Systematic Review

     

    It shows quite the opposite of what the OP study shows and used a very similar methodology except they considered a broader universe of research papers (OP's study only used two sources).  

     

    They conclude:

     

    Quote

    Some observational and clinical studies lead to CBD’s effectiveness and safety in chronic pain; however, the evidence is not strong enough to obtain a proper recommendation. It is essential to know that pure CBD extract is a strong candidate as an alternative to opioid medication since it is nonintoxicating and dependence is less. 

     

    The OP study's last finding sort of really gets at their agenda.  

     

    Quote

    A meta-analysis (which combines data from multiple studies and plays a fundamental role in evidence-based health care) links CBD to increased rates of serious adverse events, including liver toxicity.

     

    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury

     

    Quote

    High daily doses of cannabidiol are associated with frequent serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice. The lower doses of cannabidiol found typically in over-the-counter CBD products are generally well tolerated without evidence of liver injury.

     

    I found the last OP point a little head scratching when I read it because everything I've ever read about CBD has said that while it can increase liver function, that is easily managed by seeking the advice of a physician to do liver function tests.  

     

    But in the OP findings they list all of this scarey info about over the counter CBD, like the purity, and make it sound like over the counter CBD can cause liver damage.  But their conclusion is based on pharmaceutical grade CBD which is many times stronger than over the counter products.  

     

    Quote

    However, CBD products sold on the retail market are not covered by trade standards, meaning there is no requirement for them to be consistent in content or quality.

     

    This has nothing to do with the effecy of CBD.  It's a public policy and public health issue that the government doesn't better regulate these products.  

     

    Quote

    Dr. Andrew Moore, study co-author and former senior pain researcher in the Nuffield Division of Anaesthetics at the University of Oxford, said, "For too many people with chronic pain, there's no medicine that manages their pain. Chronic pain can be awful, so people are very motivated to find pain relief by any means. This makes them vulnerable to the wild promises made about CBD."

     

    Or guys selling VR pain mangement headsets.  

     

    Quote

    He added that health care regulators appear reluctant to act against the spurious claims made by some manufacturers of CBD products, possibly because they don't want to interfere in a booming market

     

    Again, this has nothing to do with their study.  This is all FUD they spew out because, like he said, people are desperate to relieve chronic pain and the more people that try CBD, the less people will spend money on more expensive treatments.  

     

    In fact, that's probably the biggest hole in their research.  The fact that many people seek out CBD while they're being prescribed opioids.  People want to get off the hard pharmaceuticals and try something that won't leave them whacked out like opioids do.  

     

    If chronic pain is as bad as he claims, wouldn't they stick with the opioids?  

     

    If you take someone and you offer them opioids or CBD and they try both for a month and they come back and say they'll stick with the CBD, wouldn't that indicate that CBD is in some way offering them a better quality of life over opioids?

     

    If we are to believe this study, CBD must be the only drug in the world where people voluntarily forego stronger and better pain management medications to take one that is completely ineffective.  

     

    Somehow I have a hard time accepting the fact that in a world where people doctor shop, get multiple prescriptions, take illegal drugs, etc, that there's a significant number of people who are like, "Oxycotin?  Nah, I prefer CBD" if CBD is completely ineffective at pain management.  

     

    Yet, nearly everywhere that cannabis is legal, there are reports of reduced opioid use as patients opt for CBD.  

     

    Quote

    "Untreated chronic pain is known to seriously damage quality of life, and many people live with pain every day and for the rest of their lives," said Professor Eccleston. "Pain deserves investment in serious science to find serious solutions."

     

    Wow, a doctor that has developed a VR headset thinks the government should shovel more money into his area of study?  Amazing.  I didn't see that one coming.  LOL.  

    • Like 1
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  6. 1 hour ago, Tropicalevo said:

    Doctors prescribe smoking cannabis?

    I do not think that they would do that.

    Sucking anything except air into your lungs is bad for you.

     

    Cannabis has methods of consumption other than smoking.  

     

    • Edibles (cookies, brownies, gummies, etc)
    • Pills (I just got a bunch of micro-dose capsules as a sample from a grower)
    • IV 
    • Patches (transdermal) 
    • I'm pretty sure PrikPot in Chiang Mai sells snus-like satchels with cannabis (decarb it in tea or coffee for a nice high) 
    • Vaping (you claim sucking anything except air into your lungs is bad for you but many drugs are available as inhalers - ie asthma meds)

    If there's a way for doctors to administer a medication, there's a good shot you can deliver cannabinoids via the same method.  

    • Confused 1
    • Agree 1
  7. 39 minutes ago, JBChiangRai said:


    You couldn’t be more wrong, Cannabis Use Disorder is a huge problem and on the subject of addiction…

     

    Contrary to popular belief, people can become addicted to cannabis. Continued, frequent and heavy cannabis use can cause physical dependency and addiction. Some people can develop tolerance to the effects of cannabis. Tolerance is characterized by a need for larger doses of a drug to maintain the same effects.

     

    https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/health-effects/addiction.html#

     

    It feels so strange being super pro-cannabis but also needing to correct people for making wildly inaccurate claims about weed.  

     

    Anybody that says cannabis isn't addictive isn't worth taking seriously in any conversation about cannabis.  The fact that your link is the first result of millions all saying that cannabis can be addictive for some people means that OP didn't even do the cursory google search before making a medical claim.  What other topics can you possibly discuss with someone that is willfully ignorant?  

    • Sad 1
  8. 11 minutes ago, HugoFastor said:

    Yes, I will admit it's very hard for me to focus on a wall of verbose text when someone is spewing utter mindless and unfounded rubbish, but I'm working on my problem. 😉

     

    How would you know that it's utter mindless and unfounded rubbish if you didn't read it?  

     

    You can't have it both ways.  Either you read it and you thought you would be witty by saying you didn't, or you realized very early that I was going to be refuting some of the stuff you made up so you quit reading it and tried to dismiss it because you can't defend what you said.  

  9. 12 minutes ago, HugoFastor said:


    Starting April 1 you will be permitted to grow 3 cannabis plants at home anywhere in Germany without any regulation on it. They can grow as big and contain as much THC as you want them too. Germany is a highly functioning, civilized and regulated society. They obviously don't see any issues with it because it isn't a problem. So why should anywhere else be concerned about it?

     

    If they put a limit on the number you could grow, it does sound like they see some issues.  

    • Confused 1
  10. The cheapest thing. you're going to find that is in any way even remotely accurate is a Purple Pro which retails for around 100,000 baht in Thailand (closer to $2K in the US and other markets). 

     

    They don't sell these machines on Lazada so you'll need to contact a rep on Facebook or LINE and inquire about purchasing. 

     

    The other popular testing rig is the GemmaCert which, IIRC, runs around 200,000 or 250,000 baht. 

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