I think Xolair was originally introduced as powder and later they switched it to prefilled syringes for convenience, but maybe that given the cost of this medication there is not so much demand for the syringes in Thailand and they have a limited shelf life even if refrigerated, whereas powder prob has much longer shelf life so they stick to powder at most hospitals. It is possible that the top hospitals like Bumrungrad do offer syringes but the price they quoted me was crazy, like 2x the price at Vichayut. Unfortunately, Xolair is expensive because even after like 20 years there is no generic substitute available so the branded can charge whatever they want for it. The question if Xolair can create a long term remission of urticaria or only suppress it is controversial and I got different replies to that from different specialists. Never tried ciclosporin, it is a somewhat risky medication and requires frequent blood monitoring. In my case antihistamines do help but need to take a huge dose, 3-4x the normal dose used for standard allergy treatment. My urticaria tends to quiet down, then flare up after any sort of infection like a flu or covid that revvs up my immune system.