What people don't know, they don't miss. If people had never experienced the Internet, TV, cell phones, refrigerators, electricity. modern medicine etc, would their lives have been any better or worse? If people expect to die, for example, between the ages of 40 and 50 (on average), they won't expect to retire and live in nursing homes into their 80's and 90's.
One thing is certain. modern medicine has weakened the gene pool of humanity. There's no more "only the strongest survive", but now everyone (can) survive... and thus spreading inferior genes that would never have survived centuries ago. Of course this only applies to people living in developed nations. The poor in undeveloped nations are still dying young.