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retiree

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Posts posted by retiree

  1. Can't say that either the before or after seemed particularly appealing.   From their Shopee site via google lens -- at best it has no effect at all. 

    • Key Feature: Contains "Tealoss™" Prepared Purple Tea Complex for weight management.
    • Ingredients: Includes natural extracts such as purple tea powder, Garcinia cambogia, unroasted coffee bean, L-carnitine L-tartrate, Citrus aurantium, white kidney bean, chili, dandelion, and black galingale.
    • Quantity: Each box contains 10 capsules.
    • Registration Number: The product is registered under the number 13-1-14959-5-1572.

    Galangal helps with weight loss and flatulence. Citrus hystrix helps speed up metabolism and increase fat breakdown. Dandelion helps increase bile secretion and detoxify the soil. Chili stimulates metabolism and increases satiety. Unroasted coffee beans help inhibit the absorption of sugars and carbohydrates in food. Garcinia cambogia helps inhibit the conversion of new enzymes to reduce appetite. Purple tea helps burn fat and inhibit fat accumulation. L-Carnitine and L-Tartrate help reduce fat and increase muscle mass. White kidney beans cause the body to absorb less sugar from carbohydrates.

     

     

    https://down-th.img.susercontent.com/file/th-11134207-81zth-meqyzavy4r298c

  2. On 9/21/2025 at 9:14 PM, Yellowtail said:

    I used to update a PDF each year and submit it. Can it still be done like this?

    I just did that a few weeks ago. There is a mechanism on their site that doesn't require logging in.

     

    I just look up the exchange rate for December 31st, take a generous guess at my highest balance for the year and fill in the new numbers.  Quick and easy.

  3. On 9/4/2025 at 7:02 AM, Zaphod Priest said:

    There was no "decision to submit for publication".   GSK is committed to publishing  ...

    On 9/5/2025 at 12:16 AM, Lorry said:

    Tell this to the authors of the study, not me, as it was a quote from the study.

     

    Everybody's a winner here.  GSK can have a default policy, but Lancet can have a boilerplate disclosure form.

     

    Fwiw more folks are looking at registered but unpublished studies these days, as well as comparing the outcomes of industry vs. independent funding.  This came out a few years ago on one of this forum's perennial favorite topics:  knee injections.  It's worth reading, if just for a look at the methodology and presentation. 

     

    Pereira, Tiago V., Peter Jüni, Pakeezah Saadat, Dan Xing, Liang Yao, Pavlos Bobos, Arnav Agarwal, Cesar A. Hincapié, and Bruno R. da Costa. "Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis." bmj 378 (2022).

    https://www.bmj.com/content/378/bmj-2022-069722 (open access) 

    We found that viscosupplementation was significantly associated with a small reduction in pain intensity compared with placebo, but the difference was less than the minimal clinically important between-group difference.

     

  4. 38 minutes ago, Lorry said:

     

    Thx, nice.

    It would be nicer if they wouldn't have to write :

    The funder of the study was GSK who was involved in study design, data collection, data analysis, data interpretation, writing of the report, and the decision to submit for publication.

     

    Ana Strezova a,∗, Javier Díez Domingo b,c, Anthony L Cunningham d,e, Takashi Eto f, Charles Andrews g, Clovis Arns h, Eun-Ju Choo i, David Shu Cheong Hui j, Giancarlo Icardi k,l, Shelly A McNeil m, Airi Põder n, Pavel Kosina o, Lars Rombo p, Tino F Schwarz q, Juan Carlos Tinoco r, Chong-Jen Yu s, Jing Wang t, Jyoti Soni a, Manyee Tsang u, Rafael Leon a, Agnes Mwakingwe-Omari t; Zoster-049 Study Group

     

    ZOE-LTFU (NCT02723773) ... was conducted in 18 countries or regions (Australia, Brazil, Canada, Czech Republic, Estonia, Finland, France, Germany, Hong Kong, Italy, Japan, Mexico, Republic of Korea, Spain, Sweden, Taiwan, the United Kingdom, and the United States of America).

    The protocol was approved by necessary independent ethics committees or institutional review boards. The study was conducted in accordance with the Declaration of Helsinki and the principles of Good Clinical Practice. 

     

    It is completely appropriate -- and practically necessary -- for manufacturers to fund studies of this type.  I suspect many hundreds of people were involved in conducting and reporting on this research. And I fear the alternative would be to not have multi-country long-term studies of this type at all.

     

    If you feel that GSK interfered with the conduct of the study,  let's hear about it.  If you want to push for more public funding for research of this kind I'm right there with you. But let's not point at a standard practice as though it's some sort of indictment.

     

     

  5. On 8/20/2025 at 1:33 PM, stubuzz said:

    she is very unpleasant to be around, but no phsical symtoms or pain.

    Just me, but encourage my wife to take drugs to improve her mood would not be my go to move.

     

    And yes, I've been through it in my house.  Fortunately, my SO is pretty self aware -- she didn't like being in the grip of uncontrollable moods either -- and would just issue a steer clear alert when necessary.  Like I say, we got through it.

  6. 11 hours ago, KhunLA said:

    First, it's NOT an 'entitlement', as myself & employers invested in the fund.   That govt mismanaged the fund, as they do everything they seem to touch is why it's in trouble.

     

    There is no fund to mismanage. Social Security is a pay as you go system. Its upcoming shortfall is the result of demographics, and of Congress's failure to adjust Social Security taxes as they have done many times in the past.

     

    See this extended report from the Congressional Research Service:

    https://www.congress.gov/crs-product/R48557

  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC12235393/

     

    eClinicalMedicine 2025 May 9;83:103241. doi: 10.1016/j.eclinm.2025.103241

     

    Final analysis of the ZOE-LTFU trial to 11 years post-vaccination: efficacy of the adjuvanted recombinant zoster vaccine against herpes zoster and related complications. Ana Strezova et al

     

    Background

    Herpes zoster (HZ) vaccines should provide durable protection against HZ and HZ-related complications. We report the final analysis of a long-term follow-up (LTFU) study (ZOE-LTFU) including 11 years of follow-up after primary vaccination with recombinant zoster vaccine (RZV).

    ...

    Interpretation
    Efficacy of RZV against HZ and associated complications remained high through 11 years post-vaccination, indicating sustained clinical benefit.

     

  8. 34 minutes ago, ignis said:

    Is this BP test done everywhere in the world these days ?

     

    Not uncommon.  See e.g. this trial run in UK:

    People often think of this as some kind of "nanny state" intrusion (My hypertension is my business!) but it's more a cost-cutting measure -- the state ends up paying or subsidizing the cost of care down the road.  

  9. On 8/9/2025 at 4:24 PM, DrPhibes said:

    As you age, 120/80 is a bit unrealistic for normal due to arteries hardening and other insufficiencies. 

    Uhh, I'm over 70 and my arteries don't appear to be hard in the slightest.

     

    I think your point may be that in modern society older people tend to be awfully unhealthy, and high blood pressure is one aspect of this.  It's hardly inevitable

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