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Everything posted by Will B Good
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So you CBA reading this bit....??? 5. Emergency Use Authorization (EUA) / Approval • After Phase 3 trials, Pfizer-BioNTech and Moderna submitted data to the U.S. Food and Drug Administration (FDA) and other regulatory bodies (e.g., the European Medicines Agency or EMA) for Emergency Use Authorization (EUA). • Regulatory agencies conducted a thorough review of all data, including: • Efficacy data showing that the vaccine effectively prevented severe COVID-19 illness. • Safety data showing that the vaccines had a favorable risk-benefit profile. • After the review, both vaccines were granted EUA by the FDA in December 2020, allowing them to be administered to the public while ongoing monitoring continued.
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1-2 months plus several months plus several months......get a grip,
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Before mRNA vaccines, such as the Pfizer-BioNTech and Moderna COVID-19 vaccines, were approved for emergency or full use, they underwent several rigorous stages of testing to assess safety and efficacy. Here’s an outline of the process: 1. Preclinical Testing (Lab and Animal Studies) • Objective: To assess the safety, immune response, and potential efficacy of the vaccine. • Process: • Animal studies: Typically conducted in mice, rats, and non-human primates to evaluate whether the vaccine induces the desired immune response and does not cause harmful effects. • The mRNA technology used in the COVID-19 vaccines had been previously studied in labs for other diseases (e.g., Zika, flu, cancer), but the COVID-19 vaccines were tested in animals before moving to human trials. • Outcome: Encouraging results were obtained in animals, showing that the mRNA vaccines were effective at generating an immune response. 2. Phase 1 Clinical Trials (Initial Human Trials) • Objective: To evaluate the safety and dosage of the vaccine. • Process: • Participants: A small group (often 20-100) of healthy volunteers. • Testing: The focus was on safety, the immune response, and determining the appropriate dosage for further trials. • Outcomes: This phase helped identify any immediate, severe side effects (e.g., allergic reactions) and the optimal dose that induces a good immune response. • Duration: Typically 1-2 months. 3. Phase 2 Clinical Trials (Expanded Human Trials) • Objective: To further assess safety, side effects, and immune response in a larger group of participants. • Process: • Participants: Hundreds of volunteers, including those from various age groups and risk categories. • Testing: Vaccine doses were refined, and participants were monitored for side effects, immune responses, and any potential efficacy signals. • Outcomes: This phase confirmed the safety and immune response induced by the vaccine. • Duration: Usually several months. 4. Phase 3 Clinical Trials (Large-Scale Human Trials) • Objective: To assess the vaccine’s efficacy and safety in a much larger population. • Process: • Participants: Thousands of volunteers (often over 30,000), including people from a wide range of demographics (e.g., elderly, people with underlying health conditions). • Testing: This phase measured how well the vaccine protected against infection (or severe illness) and assessed side effects across a large group. • Outcome: • Efficacy: The mRNA vaccines showed high efficacy in preventing symptomatic COVID-19 (around 94-95% in early results for Pfizer-BioNTech and Moderna). • Safety: Serious side effects were rare, and the vaccines generally had side effects similar to those of other vaccines (e.g., soreness at the injection site, fatigue, mild fever). • Duration: Typically lasted several months to a year. 5. Emergency Use Authorization (EUA) / Approval • After Phase 3 trials, Pfizer-BioNTech and Moderna submitted data to the U.S. Food and Drug Administration (FDA) and other regulatory bodies (e.g., the European Medicines Agency or EMA) for Emergency Use Authorization (EUA). • Regulatory agencies conducted a thorough review of all data, including: • Efficacy data showing that the vaccine effectively prevented severe COVID-19 illness. • Safety data showing that the vaccines had a favorable risk-benefit profile. • After the review, both vaccines were granted EUA by the FDA in December 2020, allowing them to be administered to the public while ongoing monitoring continued. 6. Post-Approval Monitoring (Phase 4) • Objective: To continue monitoring the vaccine’s long-term safety and effectiveness in the general population. • Process: • Ongoing surveillance systems like the Vaccine Adverse Event Reporting System (VAERS) and V-safe were used to monitor adverse events, including rare or long-term side effects. • The EUA was later converted to full approval (for Pfizer-BioNTech in August 2021) based on continued safety and efficacy data. Summary: • Preclinical studies and clinical trials (Phases 1-3) assessed safety, immune response, and efficacy. • The mRNA vaccines were subjected to more rigorous testing than some other vaccine types due to the novel technology, but they followed standard protocols used for any vaccine approval. • Post-approval monitoring continues to ensure safety in the wider population. Hardly......"not tested at all"
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Don't shout at me.....I'm very delicate....this is the statement that confuses me..... Under Thai tax rules, foreign income (e.g., pensions or investment income) is taxable only if remitted to Thailand in the same calendar year it is earned. That says to me if I prove it was "earned" more than a year before I remitted it, it is tax free??????
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Of course the Trump way is best...... Trump's Amazing Accomplishments. • Promised to cut the deficit but added $8trillion to it. • Promised to build a wall; completed only 458 miles out of 2,000, mostly repairs. • Promised Mexico would pay for the wall; they didn't. • Promised a new healthcare plan; it never existed. • Promised a middle-class tax cut; primarily cut taxes for the rich, leaving the middle class to bear the burden. • Promised not to play golf; made 250 visits to his own golf clubs, costing taxpayers $150 million. • Promised to increase economic growth by 4%; didn't achieve it, President Biden did • Promised an infrastructure plan; had none, President Biden signed a massive one. • Promised to hire "the best people"; fired 3/4 of them, then labeled them the worst. • Promised to reduce prescription drug prices; didn't happen, President Biden did. • Promised to win the trade war with China; it cost about a quarter million jobs. • Promised corporate tax cuts would benefit workers;corporations used the money to buy back stocks instead. • Promised to revive the coal industry; more coal jobs were lost during his presidency. Loan forgiveness for the wealthy who took PPP loans to remodel their homes and go on vacation. Then came Jan 6th
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Not sure to be honest. I'm just trying to get to a position where I can honestly say this money I have transferred, UK to Thailand, was pension money from a previous year so it avoids tax in Thailand. If I only have one bank account with all sorts going into it how do I prove it is money that is a over a year old coming to Thialand
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A question on the Thai driving license
Will B Good replied to DineshR's topic in Thailand Motor Discussion
Once you turn 70 you have apply for new one to commence from your 70th birthday then reapply every three years after that. -
A question on the Thai driving license
Will B Good replied to DineshR's topic in Thailand Motor Discussion
Whoops! -
A question on the Thai driving license
Will B Good replied to DineshR's topic in Thailand Motor Discussion
So if I went back to the UK for holiday, having let my UK licence lapse......I could still hire a car say using my Thai licence??? Not sure why I think you should know the answer, but thought I would ask anyway. -
Yes, Thai wife, Thai bank account.....and I have my own Thai bank account. Someone did suggest another way........just stick the 400k in my Thai account and 'forget about it'......just use that account every year for the extension based on marriage......but still keep the 'gift to the wife' idea going to cover our living expenses.
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You may well be correct..... As Mayor of London, Boris Johnson instigated the closure 12 fire stations and a retirement of 18 fire engines in London as part of cost-saving measures. He took this action prior to the Grenfell disaster....oh wait......Johnson was our poundshop Trump....not a good example to raise for you.