Just got back from Khon Kaen.
I always enjoy that city!
1.5 hours is the distance between the two. Frequent cheap buses or a private taxi for 1400 baht or even the train in 3-4 hours.
We stay at the Pullman Khon Kaen. Classic old Hotel with a huge Lobby, about 2,500 baht with breakfast.
Brand new: Adlib hotel with promotions.
https://www.adlibhotels.co/khon-kaen/?gclid=Cj0KCQiA-oqdBhDfARIsAO0TrGHFqO3Vf23mQeh2b181cxxjAGbnU02kokSMAdSJUeJ6Qd34dvGIDKIaAipCEALw_wcB&gclsrc=aw.ds
Pannarai hotel offers is really nice and in the center of everything. Nightlife, restaurants, and Central Shopping Mall (Robinsons).
Bus station and train station all within walking distance.
Both Issan cities are good fun and full of gorgeous ladies!
Lots of restaurants,bars, and shopping.
Have a great time!