Paxlovid COVID Pills Have No Benefit for Adults 40-65, Study Shows

[Danderman123]

https://www.thedailybeast.com/paxlovid-covid-pills-used-to-treat-biden-have-no-benefit-for-a-lot-of-adults-study?ref=home

 

And with a 5 day relapse for those seniors who use it. 
 

 

[Lorry]

The title of your thread is old news,  and, unfortunately,  true.

 

Your sentence about seniors is your invention and a lie.

Few people have a relapse.

[TallGuyJohninBKK]

Be fair in reporting the full results of the cited study, per the original source of your OP news report:

 

"The researchers found that Paxlovid reduced hospitalizations among people 65 and older by roughly 75% when given shortly after infection. That's consistent with earlier results used to authorize the drug in the U.S. and other nations."

 

AND

 

"The study has limitations due to its design, which compiled data from a large Israeli health system rather than enrolling patients in a randomized study with a control group — the gold standard for medical research."

 

https://www.usatoday.com/story/news/health/2022/08/24/paxlovid-pfizer-covid-pill-benefits-adults/7889907001/

 

It's not a perfect medication. But it's not a useless one either.

 

Edited August 25, 2022 by TallGuyJohninBKK

[Sheryl]

It does have benefit for people under age 65 who have other risk factors.

 

The clinical trials were unable to show a benefit in people under 65 with no special risk factors because the outcome being measured (need for hospitalization) was already so infrequent even in the control group. 

 

This has all been known from the start.

 

Relapse is rare.

[Danderman123]

9 hours ago, Lorry said:

The title of your thread is old news,  and, unfortunately,  true.

 

Your sentence about seniors is your invention and a lie.

Few people have a relapse.

You can tell CDC they are lying:

 

https://emergency.cdc.gov/han/2022/pdf/CDC_HAN_467.pdf

[Danderman123]

6 hours ago, Sheryl said:

 

 

Relapse is rare.

https://emergency.cdc.gov/han/2022/pdf/CDC_HAN_467.pdf

[Sheryl]

1 hour ago, Danderman123 said:

https://emergency.cdc.gov/han/2022/pdf/CDC_HAN_467.pdf

 

Nothing in that address the frequency of rebound. Rather it discussed the significance of rebound (little to none) and indications for its management (no need to to retreat).

 

Incidence of rebound after Paxlovid is low.  1-2% in some studies, 3-5% in others. Nowhere has the CDC or anyone else said it is common or usual, far from it.

[LosLobo]

7 minutes ago, Sheryl said:

 

Nothing in that address the frequency of rebound. Rather it discussed the significance of rebound (little to none) and indications for its management (no need to to retreat).

 

Incidence of rebound after Paxlovid is low.  1-2% in some studies, 3-5% in others. Nowhere has the CDC or anyone else said it is common or usual, far from it.

I recently watched FoxNews and their take on Paxlovid was that because of the anecdotal evidence of both Biden and wife getting rebound, the CDC recommendation was a "joke". This seems to be in line with their usual COVID narrative.

[Danderman123]

51 minutes ago, Sheryl said:

 

Nothing in that address the frequency of rebound. Rather it discussed the significance of rebound (little to none) and indications for its management (no need to to retreat).

 

Incidence of rebound after Paxlovid is low.  1-2% in some studies, 3-5% in others. Nowhere has the CDC or anyone else said it is common or usual, far from it.

https://www.nature.com/articles/d41586-022-02121-z
 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258292/

[TallGuyJohninBKK]

4 hours ago, Danderman123 said:

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258292/

The upshot of your above cited study:

 

"Conclusions and Relevance COVID-19 rebound occurred both after Paxlovid and Molnupiravir, especially in patients with underlying medical conditions. This indicates that COVID-19 rebound is not unique to Paxlovid and the risks were similar for Paxlovid and Molnupiravir. For both drugs the rates of COVID-19 rebound increased with time after treatments."

 

 

[Sheryl]

11 hours ago, LosLobo said:

I recently watched FoxNews and their take on Paxlovid was that because of the anecdotal evidence of both Biden and wife getting rebound, the CDC recommendation was a "joke". This seems to be in line with their usual COVID narrative.

Obviously what occurred with 2 people is not a valid sample.

 

should also note that both Bidens were  asymptomatic during these "rebounds". Would not have been known had they not been tested.

 

Most people of course do not undergo daily COVID testing when asymptomatic.  It is quite possible that  brief, asymptomatic resurgence of COVID antigen after apparent recovery from COVID (regardless of how or if treated)   is more common than realized since the only way to know would be  to routinely rest everyone after recovery every day for at least a month and that is hardly worth the  cost and  effort.

 

COVID rebound is not  limited to people who took Paxlovid nor in any way "caused" by Paxlovid.

 

And none of this had anything to do with Paxlovid's effectiveness in preventing serious illness, hospitalizations and death.

 

Very unfortunate that Fox News feels the need to polticize this treatment.