International consortium embarks on $57 M project to test inhaled, nasal vaccines

[TallGuyJohninBKK]

 

Five-year Mucosal Immunity in human Coronavirus Challenge (MusiCC) project will be led by Imperial College London

 

An international consortium of researchers specialising in human challenge studies is embarking on a $57 million project to develop advanced, virus-blocking coronavirus vaccines that could stop SARS-CoV-2 and other coronaviruses from infecting people in the first place.

 

Led by Imperial College London and co-funded by the European Union’s Horizon Europe Programme and the Coalition for Epidemic Preparedness Innovations (CEPI), the consortium of more than a dozen scientific teams and organisations will begin by running trials to select particular viruses and identify the best conditions under which to safely induce infection in healthy volunteers.

 

Researchers at multiple clinical research facilities will use a selected virus to try to infect healthy volunteers who have received an experimental vaccine. Unlike traditional vaccines which are injected into muscle, these experimental vaccines will be inhaled into the lungs or sprayed in the nose and are designed to induce a type of protection known as mucosal immunity, which scientists believe could be the key to stopping onward transmission of coronaviruses.

 

(more)

 

https://www.biospectrumindia.com/news/57/24361/international-consortium-embarks-on-57-m-project-to-test-inhaled-nasal-vaccines-against-viral-infection.html

 

 

"As the lead and convener of the consortium, Imperial will work with all MusiCC partners, including, for example, the University of Antwerp’s Vaccinopolis in Belgium, to establish human challenge models that can be used in multiple trial sites. The trials will test potential mucosal vaccine candidates against betacoronaviruses – the sub-family of coronaviruses that includes the SARS-CoV-2 virus that causes COVID-19, several seasonal viruses that cause common colds, and the MERS coronavirus that causes Middle East Respiratory Syndrome. 

 

Using harmonised standard operating procedures, the trials will take place across several sites in the UK, Europe, the United States and Singapore and will each involve a small group of young, healthy volunteers. In the challenge trial, volunteers will first receive either a dose of an investigational vaccine designed to provide mucosal coronavirus immunity or placebo before being intentionally exposed to a calibrated dose of SARS-CoV-2."

 

https://cepi.net/global-consortium-plans-coordinated-human-challenge-studies-hunt-transmission-blocking-coronavirus

 

 

Edited March 13 by TallGuyJohninBKK

[flyingtlger]

I hate putting anything in my nose ...