Beyonce and Solange undergo breast cancer testing after dad Mathew's diagnosis

 

Beyonce and Solange have been tested to see if they carry the BRCA2 gene mutation

 

Beyonce has undergone tests for breast cancer after her dad was diagnosed with the disease.

 

The singer, 38, and her sister Solange, 33, were screened to see if they carried the potentially fatal BRCA2 gene mutation, after Mathew Knowles discovered his illness.

 

Yesterday, the 67-year-old opened up about his battle on ABC’s Good Morning America.

 

Mr Knowles said: “This is genetics.

 

Full Story: https://www.mirror.co.uk/3am/celebrity-news/beyonce-solange-undergo-breast-cancer-20391940

These genetic tests for known risk genes are a real help to those at risk.

it is not because you are a carrier, that you will express the gene, that is what epigenetics is for... imagine she might do like "angelina crazy not so jolie anymore", than a horde of blind crazy fans might do the same if they find the gene

2 hours ago, justin case said:

it is not because you are a carrier, that you will express the gene, that is what epigenetics is for... imagine she might do like "angelina crazy not so jolie anymore", than a horde of blind crazy fans might do the same if they find the gene

You don't understand the genetics. It is the lack of function of the gene that causes the harm.

 

The BRCA1 gene produces a protein that repairs damage to DNA, an essential pathway in prevention of cancer, which is caused by DNA damage.

 

People with the BRCA1 mutation that increases risk make a faulty protein that doesn't actually work. It is when it IS expressed that it causes the problem, because when called upon to repair DNA damage, it can't.  When DNA damage persists unrepaired cancer risk shoots up.

 

So the problem is having not enough working BRCA1 protein. If you have the mutation you have the problem, because cells need to make the protein to prevent DNA damage.

then you use medicine or herbs  that acetylate the dna in stead of methylate

 

it is not because you have the gene, that it is expressed !

 

EPI-GENETICS rule genetics

4 hours ago, justin case said:

then you use medicine or herbs  that acetylate the dna in stead of methylate

 

it is not because you have the gene, that it is expressed !

 

EPI-GENETICS rule genetics

You still are showing that you don't understand.

 

Turning off expression of the gene would not help.

 

It is not the expression of the faulty protein that causes the problem, so turning it off would not help the problem. It is that the expressed protein is not functional. Turning expression of the mutant gene off or leaving it on still means you only have half the normal amount of necessary working protein to protect you.

 

Your "explanation"  is like saying "Well if drug X doesn't work to cure leprosy, solve this problem by not taking drug X."  But you still have leprosy in both cases!

A better explanatory analogy:   a motor bike needs two functioning wheels to work, just as a breast cell needs two functioning BRCA1 genes to prevent cancer.

 

If one of your wheels is bent the motorbike doesn't work.  If one of your BRCA1 genes is broken (has a risk mutation)  the normal one alone is not enough to make your cancer protection mechanism work, just as the one normal wheel on your bike is not enough to allow it to function.

 

Taking the bent wheel off the bike is the same as stopping the faulty BRCA1 mutant being expressed (epigenetically or any other way). It still doesn't allow the bike to work, or the cell to protect itself from cancer, because you still need two normal ones to function.