asiacurious Posted June 11, 2021 Share Posted June 11, 2021 (edited) A one-quarter dose of the Moderna mRNA vaccine has almost the same efficacy as a full dose. This has huge implications for getting more people vaccinated, sooner. The same review also finds that, "for countries choosing between approved but lower efficacy vaccines available immediately and waiting for mRNA vaccines, using immediately available vaccines typically reduces mortality." It's probably safe to expect we'll hear a lot more about dose stretching in the future. Here's a graph that lays out the efficacy rates for partial doses of all the major vaccines: Here's a video presentation by the authors: And here's a link to the page announcing this data: https://marginalrevolution.com/marginalrevolution/2021/06/a-half-dose-of-moderna-is-more-effective-than-a-full-dose-of-astrazeneca.html Finally, here's the full pdf for those who want to read the working paper. Edited June 11, 2021 by Crossy Fixed typo in OP to avoid confusion Link to comment Share on other sites More sharing options...
internationalism Posted June 12, 2021 Share Posted June 12, 2021 a similar story with AZ from the last year. For the first shot half of recommended dose appeared more effective. And now they are stretching gap from 2 weeks to 4 months. Might be something in it. Lower dose and longer gap might give less undesired side effects 1 Link to comment Share on other sites More sharing options...
Hyna Posted June 12, 2021 Share Posted June 12, 2021 (edited) 2 hours ago, internationalism said: a similar story with AZ from the last year. For the first shot half of recommended dose appeared more effective. And now they are stretching gap from 2 weeks to 4 months. Might be something in it. Lower dose and longer gap might give less undesired side effects After reading the published phase III studies of Moderna and Pfizer, some people asked "Why didn't they test lower doses?" Because the results looked like lower doses would be good enough. Of course, that would have cost time. The numbers of participants here are very low. And neutralizing antibodies might not be that relevant. New phase III studies would be necessary. Edited June 12, 2021 by Hyna 1 Link to comment Share on other sites More sharing options...
Pattaya Spotter Posted June 12, 2021 Share Posted June 12, 2021 (edited) Dang that Moderna mRNA juice is good stuff! Edited June 12, 2021 by Pattaya Spotter Link to comment Share on other sites More sharing options...
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