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UP Chemists Innovates AI to Battle Antimicrobial Threats

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Photo courtesy of Inquirer

Chemists from the University of the Philippines Diliman have created an AI tool named Iscape, which promises to speed up the discovery of antibacterial peptides. This innovation aims to tackle the pressing issue of antimicrobial resistance, making antibiotics more ineffective globally. The AI tool streamlines the process, predicting a peptide's ability to combat E. coli, thus simplifying molecule evaluation.

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Antimicrobial resistance poses a significant threat as it renders diseases harder to treat, linking to millions of deaths in 2015 alone. The Iscape tool, developed by Remmer Salas, Dr. Portia Mahal Sabido, and Dr. Ricky Nellas, leverages AI to learn from data and pinpoint active peptides, helping researchers save time previously spent on traditional, lengthy testing methods.

Unlike many AI models, Iscape reveals molecular features that make peptides effective, ensuring efficient design better suited to tackle bacterial strains. However, adapting Iscape to other bacteria requires high-quality, curated datasets and retraining for specific targets. The tool also holds potential for predicting the activity of other bioactive peptides, given the right datasets.

The researchers are hopeful that Iscape will enhance the design of new antibacterial treatments, contributing significantly to combatting antimicrobial resistance globally. As they continue refining the model, its applications could expand, offering vital tools in the ongoing fight against drug-resistant infections.

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image.png  Adapted by ASEAN Now · Inquirer · 15 May 2026

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