Interesting, at nearly 4 times the price I won't bother with Descovy, makes sense if someone has some kind of adverse reaction to Truvada generic. I asked a Dr at Red Cross that question about if there's an adverse reaction and he said stop taking and kidneys recover, i haven't looked into it further but you may be right. I just checked my results again, it's 6 years and my Creatinine is almost exactly the same as when I started.
BTW some people just react to taking PrEP, not specifically long term use, hence why it's normal to get checked from the beginning every 6 months or so, they seem more relaxed about that, used to be every 4 month visit for me, now 8 months