Type II Product Trials

[chiang mai]

As part of my search for the latest developments on the Diabetes front I came across the following from Diabetes UK and I wanted to share it with the forum, I was impressed with the concept and have my fingers crossed for the future:

http://www.diabetes.co.uk/weight/endobarrier.html

To be clear, the product that is described here is not yet approved and is currently undergoing trials, it does however have licensing in a couple of countries and as a concept it appears promissing.

I trust that posting this information here does not violate forum rules since it is provided as a discussion and informational point rather than being presented as a cure or a solution.

[Sheryl]

This is simply gastric banding, a surgical treatment for obesity. appears to be an ad placed by one manufacturer of a device used for that (there are several, all similar in how they work). I don' know where you get "Type II Product Trail" from. The device (and others like it) have AFAIK completed the testing phase already.

It would be indicated only for people who are significantly obese and unable to loose weight by conventional measures (diet, exercise). The usual rec is a BMI over 40 or , in the case of someone with obesity-associated health problems like diabetes, over 35. That is seriously heavy.

Since obesity definitely aggravates diabetes, a diabetic with severe obesity would likely have better control if the procedure was successful in reducing their weight (not that gastric banding does not always work, and there are risks associated).

See here for a full overview of the procedure:

http://www.mayoclinic.org/medical-edge-newspaper-2010/jan-08b.html

[chiang mai]

You've not understood the product that's being described here and it's certainly not gastric banding.

The product is called EndoBarrier and comprises a length of what seems to be pigs gut which is inserted into the start of the small intestine, this tube of skin is then held in place by a metal clip. The priniciple is that food will pass from the stomach into the small bowel but absorption during the first twelve inches or so of travel is prevented by virtue of the EndoBarrier thus is delayed until further into the small intestine. The product requires no surgery for either installation or removal, the latter must be done within twelve months.

[chiang mai]

You've not understood the product that's being described here and it's certainly not gastric banding.

The product is called EndoBarrier and comprises a length of what seems to be pigs gut which is inserted into the start of the small intestine, this tube of skin is then held in place by a metal clip. The priniciple is that food will pass from the stomach into the small bowel but absorption during the first twelve inches or so of travel is prevented by virtue of the EndoBarrier thus is delayed until further into the small intestine. The product requires no surgery for either installation or removal, the latter must be done within twelve months.

Here's the link to the product itself which explains the trial and the device in more detail:

http://www.gidynamics.com/endobarrier-overview.php

[Sheryl]

You are right, my mistake. The second link makes it much clearer.

Apparently it is already approved for use in some European countries. Here is a report if the d=first study done on it:

http://www.ncbi.nlm.nih.gov/pubmed/19858703

And here is a description of the phase II clinical trial now underway i nthe US:

http://clinicaltrials.gov/ct2/show/NCT01728116