Given the serious and specialized nature of the medication (and,presumably, your underlying condition) I think it will prove difficult to get a one year supply in the UK. You will also likely run into problems getting an online prescription. I am not sure even your GP would be comfortable prescribing it unless he has a specialist recommendation to do so. Be aware too that it has become more difficult to receive medications by mail in Thailand and there are increasing reports of parcels being confiscated. It was always technically illegal to receive meds by mail unless one held n FDA license to do so, but in the past customs usually let small parcels through. Ever since they began levying tax on even low value parcels, scrutiny has increased. While there is no other brand of sirolimus registered in Thailand, there are lower cost brands of the drug tacrolimus (brand name: Tacrograf, made by BerlinPharma) which has similar action and would will surely cost less than Rapamune. Tacrolimus is usually the first line drug used to prevent rejection of kidney transplant, while sirolimus would be used as alternative if tacrolimus produced serious side effects. If you were not previously on tacrolimus, and if treatment is related to a transplant, you might discuss with your doctor whether you could switch. (Do not switch on your own, the drugs are not identicial and many factors go into which is prescribed).