Absolutely no vacuum. Never, ever vacuum a computer. It can build up an elecrostatic chock that can ruin the whole thing. I've worked in computer repair and have seen it happen countless times.
Doubtlessly, some individuals are going to chime in and say they've vacuumed their computers for 85 years without issue, but you wouldn't listen to a nutjob who says there's no issue with riding your motorcycle without a helmet, and neither should you listen to these people.