Thailand Successfully Produced The World's First Vaccine Against Dengue Fever

[sydneyjed]

I thought that was what he was explaining...the symptons of dengue fever!!!So that's just the vaccine 'side effects'??Sounds like a hard night out on the Leo!!!

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Hell, they should use this stuff for prisoner interrogation purposes. Having had dengue, the symptoms were a piece of cake, compared to the note above.

[softgeorge]

The vaccine is designed to protect against the four main strains of dengue fever (ABC News)

Vaccine for dengue fever trialled

Updated Mon Sep 20, 2010 1:31pm AEST

The vaccine is designed to protect against the four main strains of dengue fever (ABC News)

Researchers in Perth are hoping a new vaccine against the potentially deadly dengue fever will be available within five years.

The mosquito-borne virus, which causes severe fever, vomiting, headaches and joint pain, is present in all tropical regions around the world.

The Institute for Child Health Research's Peter Richmond says his team is about to conduct the final set of clinical trials before the vaccine can become commercially available.

He says it has taken 10 years to develop the vaccine which is now one step away from becoming licensed.

"They've engineered it so that you can get protection from the four main strains of dengue from the one vaccination - so that will stop you getting dengue at all

[softgeorge]

Thailand haven't even tested it on humans so how do they know. Do they work with other scientists from around the world?

Sorry but they missed out on 1st place for this one.

[h5kaf]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

I must protest here! Though I don't think we have met you have plagiarised my latest health check report. As this is supposed to be confidential I am a little upset that all and sundry now know what is possible as one ages. Though I feel OK most of the time the above symptoms can be a nuisance when entertaining in the early hours!!!

[Thongkorn]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Could be bad then . I think i will get a screw driver to tighten my stools in the kitchen

Edited February 22, 2011 by Thongkorn

[Nisa]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Could be bad then .

For the mice.

[bangon04]

<deleted> is going on?

Sanofi announce on Feb 19 that it was starting its tetravalent pediatric clinical trials in Thailand and it is being done in conjunction with the MOH and Mahidol.

The company named in the news article is not a developer of vaccines. It is a marketer. It also provides logistics and it can provide local technical support, but it has no proprietary vaccine R&D footprint that I know of. All of the vaccine manufacturers involved in dengue vaccine development in Thailand are either GSK, Sanofi or foreign niche biotechs using actives licensed licensed from the United States NIH

This is a very odd announcement. It is possible someone has taken something out of context.

The two key dengue vaccine hubs in Thailand are AFRIMS Virology Research Unit (KAVRU)@ Kamphaeng Mahidol University @ Ratchburi.

Is it possible someone is mixing up activities and is confused? Why would Mahidol compete against itself after working closely with Sanofi and the U.S. NIH all this time?

You seem to be much more up on this than most of us but I did check the recent news and see:

1- their was a Dengue conference held recently regarding the status of the vaccines

2 - Bill Gates foundation has released millions to help with the vaccines

3- France's vaccine is already being tested on people (including here in Thailand) and the ETA for its release is 2015 --

4 - based on animal trials the Thai vaccine is guessed to be 80% successful in humans while they results they are getting with the France vaccine are 90%

So, I am guessing you are either right that this is being reported incorrectly or that Thailand is trying to get on this bandwagon to merge with another group or somehow get funds into their project.

Reading between the lines here my interpretation goes something like this.

Big international drug company is working on a vaccine for dengue. As a part of this they are testing and trialling the vaccine in Mexico, Aus, S.America Vietnam and Thailand etc. One of the research workers in a Thailand university is seeing some success in the trials and is happy to announce loudly that the Thai part of the venture is doing good and that Thailand is a country to be taken seriously, by golly! Thai press (already knowing that Thailand is the tops) cheerfully prints story that Thailand is leading the world in dengue research and the whole Thai nations nods and applauds because a) none of them have any idea what's going on outside Thailand and b)they all know Thailand is a Serious Player anyway.

How's that?

R

Oh dear... just as the cynics were feeling they might have to start praising something that Thailand was doing exceptionally well, it all starts to come apart at the seams....

[Anyse]

All of these side effects seem to be the same as after eating a Micky D's cheapest as well as most expensive hamburger. Darn, any food from there and other places . . .

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

[dukkha]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Interesting, had dengue in Chiangmai 8 years ago and last year colon cancer....also discovered in thailand so back home in australia these days after the 10 most interesting and enjoyable years of my life...doin ok..

Mmmm no thanks I will just ride the Dengue out

Jokes aside, great development - well done.

[chooka]

Thailand have invented a process of slowing down microbial growth in food. A world 1st and the hope to release it for general use in a few yrs. They call it Pasturization.

[agudbuk]

"Tested On mice"

So far the only expected side effects are a strong desire for cheese and ailurophobia

[Nisa]

Oh dear... just as the cynics were feeling they might have to start praising something that Thailand was doing exceptionally well, it all starts to come apart at the seams....

I was thinking the same thing and then realized I wasn't seeing too many of the Serial Thai Bashers here. I think the thread heading scared them from even taking a peek into the discussion.

[Nisa]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Mmmm no thanks I will just ride the Dengue out

Jokes aside, great development - well done.

Doubt it Bridge - Pappaya Leaves juiced do exactly the same thing - look it up - and they taste like crap but knock the fever over easily and you don't need to get million dollar grants to make Big Pharma richer. Been known for decades. Just another way to make the rich richer and use the rest of us as mugs to absorb their poisons. Using a vaccine to bypass the immune system is the quickest way to shut you down and open the rest of you to more diseases. Apart from possible creating autism in kids etc. No - not well done - never.

I believe the papaya leave treatment is very likely a hoax. Snopes

It is not the juice of papayas ,,, it is the peel of a banana and you need to smoke it.

Edited February 22, 2011 by Nisa

[robsamui]

Reading between the lines here my interpretation goes something like this.

Big international drug company is working on a vaccine for dengue. As a part of this they are testing and trialling the vaccine in Mexico, Aus, S.America Vietnam and Thailand etc. One of the research workers in a Thailand university is seeing some success in the trials and is happy to announce loudly that the Thai part of the venture is doing good and that Thailand is a country to be taken seriously, by golly! Thai press (already knowing that Thailand is the tops) cheerfully prints story that Thailand is leading the world in dengue research and the whole Thai nations nods and applauds because a) none of them have any idea what's going on outside Thailand and b)they all know Thailand is a Serious Player anyway.

How's that?

R

Spot on! But what about the mice? Where do those fit in?

[webfact]

Thailand developing dengue vaccine: researcher

BANGKOK, February 22, 2011 (AFP) - Researchers in Thailand say they have developed a prototype vaccine against dengue fever and will conduct further tests with the aim of bringing it to market within a decade.

The vaccine against the mosquito-borne disease was jointly developed by scientists from Thailand's Chiang Mai University, Mahidol University and the government's National Centre for Genetic Engineering and Biotechnology.

"It's the first time in Thailand that we created a prototype vaccine against dengue that has the attributes we wanted," said Associate Professor Nopporn Sithisombat at Chiang Mai University in northern Thailand.

"Our goal is to create a vaccine against dengue fever in children" said Nopporn.

The vaccine has been tested on mice and monkeys. The next stage will be human trials, he said.

Dengue, for which there is no known treatment, causes a severe flu-like illness for most victims that lasts about a week. There are four strains, one of which is potentially lethal.

The Thai team said it had created a hybrid dengue virus that carries genes of all four types.

The developers have struck a licensing agreement with Thai biotech firm BioNet-Asia, which will further develop the vaccine with the aim of releasing the first commercial batch within 10 years, Nopporn said.

Other researchers appear ahead in the race: Sanofi Pasteur, the vaccines division of French drugmaker Sanofi-Aventis, announced in November that its dengue vaccine was in the final stage of clinical development.

In Thailand more than 115,000 people were infected and 141 died last year from dengue fever, many of them young people, according to the government.

-- (c) Copyright AFP 2011-02-22

[tim armstrong]

Reading between the lines here my interpretation goes something like this.

Big international drug company is working on a vaccine for dengue. As a part of this they are testing and trialling the vaccine in Mexico, Aus, S.America Vietnam and Thailand etc. One of the research workers in a Thailand university is seeing some success in the trials and is happy to announce loudly that the Thai part of the venture is doing good and that Thailand is a country to be taken seriously, by golly! Thai press (already knowing that Thailand is the tops) cheerfully prints story that Thailand is leading the world in dengue research and the whole Thai nations nods and applauds because a) none of them have any idea what's going on outside Thailand and b)they all know Thailand is a Serious Player anyway.

How's that?

R

Spot on! But what about the mice? Where do those fit in?

I don't care if they jump on the bandwagon, its a good news story, and there's not too many of those around. Now what about the Holy Grail - malaria. That would be a story !

[Nisa]

I don't care if they jump on the bandwagon, its a good news story, and there's not too many of those around. Now what about the Holy Grail - malaria. That would be a story !

How about just getting rid of mosquitoes? Do they serve any purpose? I'm sure the jing jongs can find something else to feed on.

[softgeorge]

Thailand developing dengue vaccine: researcher

BANGKOK, February 22, 2011 (AFP) - Researchers in Thailand say they have developed a prototype vaccine against dengue fever and will conduct further tests with the aim of bringing it to market within a decade.

The vaccine against the mosquito-borne disease was jointly developed by scientists from Thailand's Chiang Mai University, Mahidol University and the government's National Centre for Genetic Engineering and Biotechnology.

"It's the first time in Thailand that we created a prototype vaccine against dengue that has the attributes we wanted," said Associate Professor Nopporn Sithisombat at Chiang Mai University in northern Thailand.

"Our goal is to create a vaccine against dengue fever in children" said Nopporn.

The vaccine has been tested on mice and monkeys. The next stage will be human trials, he said.

Dengue, for which there is no known treatment, causes a severe flu-like illness for most victims that lasts about a week. There are four strains, one of which is potentially lethal.

The Thai team said it had created a hybrid dengue virus that carries genes of all four types.

The developers have struck a licensing agreement with Thai biotech firm BioNet-Asia, which will further develop the vaccine with the aim of releasing the first commercial batch within 10 years, Nopporn said.

Other researchers appear ahead in the race: Sanofi Pasteur, the vaccines division of French drugmaker Sanofi-Aventis, announced in November that its dengue vaccine was in the final stage of clinical development.

In Thailand more than 115,000 people were infected and 141 died last year from dengue fever, many of them young people, according to the government.

-- (c) Copyright AFP 2011-02-22

Tow totally different headlines 1. Thailand developing dengue vaccine. 2. Thailand successfully produced the worlds 1st Vaccine. Which one is it Thailand?

It sounds like they are trying to re invent the wheel. Thailand is merely following in the footsteps of other countries who are far ahead of them. Trials on humans have been conducted with positive results. Don't worry about losing face and asked these countries to educate you.

[softgeorge]

I don't care if they jump on the bandwagon, its a good news story, and there's not too many of those around. Now what about the Holy Grail - malaria. That would be a story !

How about just getting rid of mosquitoes? Do they serve any purpose? I'm sure the jing jongs can find something else to feed on.

Do you mean like this

[siampolee]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

And I thought it was the old Lao Kao after shock. !!

[Nisa]

I don't care if they jump on the bandwagon, its a good news story, and there's not too many of those around. Now what about the Holy Grail - malaria. That would be a story !

How about just getting rid of mosquitoes? Do they serve any purpose? I'm sure the jing jongs can find something else to feed on.

Do you mean like this

Wow ,,, will be interesting to see how this works out. Hopefully they will not have the same outcome that produced killer bees.

[anterian]

Reading between the lines here my interpretation goes something like this.

Big international drug company is working on a vaccine for dengue. As a part of this they are testing and trialling the vaccine in Mexico, Aus, S.America Vietnam and Thailand etc. One of the research workers in a Thailand university is seeing some success in the trials and is happy to announce loudly that the Thai part of the venture is doing good and that Thailand is a country to be taken seriously, by golly! Thai press (already knowing that Thailand is the tops) cheerfully prints story that Thailand is leading the world in dengue research and the whole Thai nations nods and applauds because a) none of them have any idea what's going on outside Thailand and b)they all know Thailand is a Serious Player anyway.

How's that?

R

Spot on! But what about the mice? Where do those fit in?

In my village the mice, and other rodents, fit in with the rice and green herbs, usually deep fried.

[WarpSpeed]

Hold on, I seem to recall a little over a year ago about a premature and inaccurate claim of a vaccine for HIV and the numbers turned out to be all skewed which once deciphered determined the vaccine was actually no more effective then current models of treatment..

I'll wait for international scrutiny and review before cracking open any champagne..

[richard10365]

Do they have open source vaccine development like they do for software? Maybe that would speed things up a bit.

[Hairy]

Do they have open source vaccine development like they do for software? Maybe that would speed things up a bit.

Yes, and modern science has also created a way for a baby to be conceived and born in only one month, by using nine women to carry it in parallel.

[yumidesign]

Good news, which will be quickly dismissed as an aberration, because Thailand's universities are all crap - according to the experts on TV.

"however, the vaccine has so far been proven effective in mice, and has yet to be tested on human" How can an education system so flawed produce a result like this. Wonder who wrote the press release

[Samuian]

Produced..

not invented, produced with the help of whom?

This article was published on 25th April 2010 by the TIMES of INDIA:

The first dengue vaccine in the world is set to be unveiled.

Developed by the Health Ministry together with a private company, the vaccine is set to become a medical breakthrough. While there are some ongoing vaccine development programmes, there has so far been no tested and approved vaccine for the dengue virus, reports The New Straits Times Online.

Source:

"Tan Sri" sounds thai, maybe someone thai who works for the indian government....ohoh... or maybe by now they work together.... on a multilateral base, or jsut the Kao San ID card Syndrome?

Why wasn't there any institute/university/research facility mentioned?

I wonder...

[robsamui]

Oh dear... just as the cynics were feeling they might have to start praising something that Thailand was doing exceptionally well, it all starts to come apart at the seams....

I was thinking the same thing and then realized I wasn't seeing too many of the Serial Thai Bashers here. I think the thread heading scared them from even taking a peek into the discussion.

When the day comes that Thailand, using its own brains and resources, achieves something world class, then I will be the first to respectfully applaud with admiration. Until that day, every time proud boasts are made with smoke and mirrors and nothing is achieved apart from a national pat on the back for nothing, I remain realistic, not cynical!

R

[robsamui]

Good news, which will be quickly dismissed as an aberration, because Thailand's universities are all crap - according to the experts on TV.

"however, the vaccine has so far been proven effective in mice, and has yet to be tested on human" How can an education system so flawed produce a result like this. Wonder who wrote the press release

Simply because an international drug company, as part of its established and ongoing longterm research, has taken its running program with all the goalposts already in place, to a Thai university (amongst two dozen others across the world.) It has provided them with money, materials and equipment and given them instructions on how to proceed. The Thai university has not 'produced' the result - although it may be true to say that the result was 'produced' at the Thai university!

Similar programs are producing successful results at Indian universities but I haven't had yet my attention drawn to headlines that India is somehow now leading the world in the battle against dengue fever!

R

Edited February 23, 2011 by robsamui

[chooka]

Good news, which will be quickly dismissed as an aberration, because Thailand's universities are all crap - according to the experts on TV.

"however, the vaccine has so far been proven effective in mice, and has yet to be tested on human" How can an education system so flawed produce a result like this. Wonder who wrote the press release

Simply because an international drug company, as part of its established and ongoing longterm research, has taken its running program with all the goalposts already in place, to a Thai university (amongst two dozen others across the world.) It has provided them with money, materials and equipment and given them instructions on how to proceed. The Thai university has not 'produced' the result - although it may be true to say that the result was 'produced' at the Thai university!

Similar programs are producing successful results at Indian universities but I haven't had yet my attention drawn to headlines that India is somehow now leading the world in the battle against dengue fever!

R

The exact same company is working with scientists in an Australian University also in Perth. However the Australian scientists have moved on from mice and have already trialed the drug on living humans. Thailand is still trailing behind. Maybe they are still trying to read the instruction booklet the drug company provided to them with the kit.