Thailand’s Government Pharmaceutical Organization (GPO) launched the second phase of human trials of its COVIC-19 HXP-GPOVac vaccine candidate on Monday, after the completion of the first-phase trials which show satisfactory immune responses in human specimens.

 

GPO Director Dr. Withoon Danwiboon said yesterday that the new clinical trials, conducted by the Faculty of Tropical Medicine of Mahidol University and commissioned by the GPO, will involve 250 volunteers who are in good health, have not been inoculated with any COVID-19 vaccine and are not infected by COVID-19.

 

The GPO’s vaccine development project is supported by PATH, a global non-profit health organization, which has provided the Thai organization with a prototype vaccine, jointly developed by the Icahn School of Medicine at Mount Sinai and the University of Texas at Austin, in the United States.

 

Full Story: https://www.thaipbsworld.com/thai-gpo-launches-2nd-phase-of-clinical-trials-of-inactivated-chimeric-vaccine/

 

-- © Copyright Thai PBS 2021-08-17

 

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250 volunteer pool sounds small, AZ used over 11,000. i seem to remember somewhere that that a recent request for volunteers was inundated with responses, will they be able to adequately cover all age groups with such a small number?

Not understanding this. Phase 1 trials are used to determine max effective dose that doesn't cause severe side effects, not efficacy of treatment.

 

15 hours ago, Peabody said:

Not understanding this. Phase 1 trials are used to determine max effective dose that doesn't cause severe side effects, not efficacy of treatment.

 

Typically Phase 1 for vaccines includes testing for immunogenicity. If it fails, why waste the money proceeding to phase 2, let alone 3? I believe Merck's failed P1 and they discontinued their investigation.

15 hours ago, it is what it is said:

250 volunteer pool sounds small, AZ used over 11,000. i seem to remember somewhere that that a recent request for volunteers was inundated with responses, will they be able to adequately cover all age groups with such a small number?

The P1/2 trials are usually small relative to P3 where drawing statistical conclusions regarding safety and efficacy require much larger numbers.

Estimated Study Completion Date  :    April 2023

 

https://clinicaltrials.gov/ct2/show/NCT04764422

 

GPO is such a scam.

 

Biggest obstacle for getting life saving vaccines.

 

There going to be dragged through the streets.

CHIMERIC How Thai to select the funniest name imagineale.

 

Like the chameleon an ever changing creature.

 

A brief look at a definition includes

 

"

hoped for but illusory or impossible to achieve.

"the notion of tolerance is a chimeric dream"

 

I hope in this nation of tolerance it works

"Satisfactory"  immune response? Is that a cautious assessment? As a prototype vaccine it will interesting to learn of progress.

On 8/18/2021 at 4:10 AM, RubbaJohnny said:

CHIMERIC How Thai to select the funniest name imagineale.

 

Like the chameleon an ever changing creature.

 

A brief look at a definition includes

 

"

hoped for but illusory or impossible to achieve.

"the notion of tolerance is a chimeric dream"

 

I hope in this nation of tolerance it works

It's a common scientific term