I feel fortunate to have been born before the extremely pervasive presence of plastics in the environment, including microplastics. So far, I guess the science tells us the following: :In recent years, nanoplastic and microplastic particles (NMPs) have emerged as substantial threats to human health, particularly as endocrine disruptors. The endocrine system is especially vulnerable to these particles due to its intricate network of hormonal regulation, in which even minor disturbances can lead to widespread physiological effects. Studies have shown the pervasive presence of NMPs in human tissues, including blood, and their potential to impair metabolic and hormonal health.1 This growing body of evidence underscores the urgent need to better understand the mechanisms by which NMPs interfere with endocrine function and to address their effect on public health." https://www.thelancet.com/journals/landia/article/PIIS2213-8587(26)00074-4/fulltext I wonder when we will have the technology to remove nanoplastic and microplastic particles from the body. https://www.sciencedirect.com/science/article/abs/pii/S100107422500837X AbstractMicroplastics (MPs) are increasingly recognized as emerging endocrine disrupting chemicals with significant implications for male reproductive health. Despite of well documentation on widespread presence in the environment, their specific effects on testosterone synthesis in humans remain insufficiently characterized. Current in vivo studies demonstrate that MPs impair androgen regulation through several interconnected mechanisms. These include oxidative stress–induced damage to Leydig cells, downregulation of antioxidant enzymes such as GPX1, disruption of the LH/cAMP/PKA/StAR signaling cascade essential for steroidogenesis, activation of NF-κB and inflammatory pathways, and induction of endoplasmic reticulum stress that accelerates testosterone metabolism. Additionally, MPs and their chemical additives interfere with steroidogenic enzymes and hormone receptors. Our review consolidates mechanistic insights linking MPs to testosterone disruption, underscores the dose-dependent nature of these effects. We also highlight critical knowledge gaps particularly the paucity of human data, the physicochemical diversity of MPs, and the long-term reversibility of endocrine disruption. ============ It would seem that nano- and micro-plastic particles, everywhere in our environment, is becoming a very hot topic of late.
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