Dengue Vaccine Results From Thailand Trial Expected By September

[webfact]

Vaccine trial results due in Sept

Pongphon Sarnsamak

The Nation

BANGKOK: -- A team of health experts who conducted a trial to test the efficacy of dengue fever vaccine expects to reveal the final result of the trial by September.

Dr Pratap Singhasivanon, dean of Mahidol University's Faculty of Tropical Medicine, who oversaw the study, said the Phase II B trial was being conducted since 2009 to test the efficacy of the dengue vaccine among 4,002 children in Ratchaburi province. The Sanofi Pasteur Clinical Study Program developed the vaccine. In the study, about 3,000 of the children were injected with the real vaccine, while the rest were given a placebo.

A research team will look at how the vaccine generates antibodies against all four serotypes of the virus that is responsible for dengue fever in children.

"So far, no adverse effects have been reported after the children were given the vaccines. I am quite sure that this vaccine is safe," he said.

The trial is being held in collaboration with the Mahidol University and International Paediatric Association to curb dengue-related haemorrhagic fever - a leading cause of hospitalisation in Southeast Asia.

During the study period, researchers need to submit reports to the Independent Data Monitoring Committee to evaluate the study before sending it to an ethics committee for approval.

Once the study is completed, the government will negotiate the price of the vaccine with the company so it can be included in the national healthcare programme. Mahidol University will hold the patent of the study.

Sanofi Pasteur started developing a dengue vaccine in the 1990s,while clinical studies with the most advanced candidate vaccine began in the 2000s.

Dengue fever is a mosquito-borne disease caused by four types of dengue viruses and is a potential threat for almost half the world's population. Of the estimated 230 million people infected annually, 2 million, mostly children, develop dengue haemorrhagic fever, a severe form of the disease.

Sanofi has now started conducting its Phase III clinical trial of dengue fever vaccine on 20,000 participants in 10 countries, including Thailand, Vietnam, Malaysia, the Philippines and Indonesia.

In the Phase III trial, the vaccine will be given to children between the ages of two and 14, and results should be revealed in the next two years.

"We hope that large-scale production of dengue vaccines will begin in 2015, with endemic countries being give the top priority," Dr Jean Lang, head of Sanofi Pasteur's Research and Development Dengue Fever programme, said.

-- The Nation 2012-06-15

[jonclark]

It never ceases to amaze me how 'good news' always fails to generate less comments than 'bad' news.

Hopefully this vaccine will be a success and that the hundreds of thousands infected each year will in the future become a thing of the past.

Also good to see a Thai university being used a research facility, hopefully more will follow suit and become more active in the development and progress of Thailand. Good on ya Mahidol

[drdoom6996]

It never ceases to amaze me how 'good news' always fails to generate less comments than 'bad' news.

Hopefully this vaccine will be a success and that the hundreds of thousands infected each year will in the future become a thing of the past.

Also good to see a Thai university being used a research facility, hopefully more will follow suit and become more active in the development and progress of Thailand. Good on ya Mahidol

I agree with you on both statements. When an educated article was posted about plasmodium falciprum Malaria, the most deadly kind of Malaria, most joked. I started unsing a different kind of bug spray and long sleves at night. And it was not deet. Do they educate them selves before posting such crap, no. And people believe their BS. Picaridin is more effective than deet if anyone out there is interested. I hope this vaccine is found to be an answer for Dengue.

[redroo]

Dangers Of Deet

We are not big fans of Deet as you will find out...

Deet will basically prevent creatures such as mosquitos biting the skin.

Prime Time Live ran an expose on the dangers of DEET on May 31, 1995. Insect repellents containing the chemical DEET are dangerous for human use, but political pressure from major chemical companies confounds attempts to regulate the dangerous ingredient. DEET is considered responsible for side effects including rashes, muscle twitching,confusion, slurred speech, seizures and even death. Most poison reactions to DEET probably go undetected even though nearly 5,000 DEET-related cases are reported each year to the National Centers for Poison Control.

DEET (N,N-diethyl-meta-toluamide) is arguably the most widely recommended active ingredient in insect repellents. DEET does not kill insects. Instead it prevents biting insects like mosquitoes and ticks from zeroing in on your skin.

Biting insects follow the scent of carbon dioxide gas to find a meal. Skin and breath naturally give off a carbon dioxide. By spreading a small amount of DEET on exposed skin and applying it to external clothing, insects cannot readily locate the source of the carbon dioxide.

Older products containing DEET may have had misleading labels that included a child safety claim for concentrations of 15% or less. When the EPA reassessed DEET in 1998 it mandated that the child safety claim be discontinued, finding that the concentration of DEET was irrelevant; following directions was deemed to be critical.

DEET is a registered pesticide. DEET is short for N,N-diethyl-m-toluamide (also known as N,N-diethyl-3-methylbenzamide). It is a member of the toluene chemical family. Toluene is an organic solvent used in rubber and plastic cements and paint removers. DEET is absorbed through the skin and passes into the blood. The Medical Sciences Bulletin, published by Pharmaceutical Information Associates Ltd. reports, "Up to 56% of DEET applied topically penetrates intact human skin and 17% is absorbed into the bloodstream." Blood concentrations of about 3 mg per litre have been reported several hours after DEET repellent was applied to skin in the

prescribed fashion.

DEET is also absorbed by the gut.

The most serious concerns about DEET are its effects on the central nervous system. Dr. Mohammed Abou-Donia of Duke University studied lab animals' performance of neuro-behavioural tasks requiring muscle co-ordination.

He found that lab animals exposed to the equivalent of average human doses of DEET performed far worse than untreated animals. Abou-Donia also found that combined exposure to DEET and permethrin, a mosquito spray ingredient, can lead to motor deficits and learning and memory dysfunction.

An emergency medicine bulletin notes that DEET may have significantly greater toxicity when combined with ethyl and isopropyl alcohols and freon which are components of some DEET repellents. In 1998, the US EPA made it illegal for any product containing DEET to make any child safety claims. Products with DEET are required to carry instructions that they should not be used at all for children under 6 months.

Additional required warnings state that for children 6 months to 2 years, only concentrations of less than 10% DEET should be used, and only once a day. For children from 2 -12 years old, only concentrations under 10% should be used, and repellents should not be applied more than 3 times a day.

For adults, Health Canada has now banned products with DEET concentrations over 30%, citing health risks and evidence that increasing the percentage does not do much more to repel insects. Health Canada has also banned two in one products which combine sunscreen and DEET, saying they create the potential for people be exposed to too much DEET. The ban does not take effect until December 2004, so consumers may want to be careful not to pick up combination products still on store shelves.

Products containing DEET are now required to carry labels which specify:

-Do not apply over cuts, wounds, or irritated skin.

-Do not apply to hands or near eyes and mouth of young children.

-Do not allow young children to apply this product.

-After returning indoors, wash treated skin with soap and water.

-Do not use under clothing.

-Do not spray in enclosed areas.

Experts recommend that if using DEET, its best to wear long sleeves and long pants, when possible, and apply repellent to clothing rather than skin to reduce exposure. They state DEET based products should only be applied sparingly; saturation does not increase efficiency. DEET repellents should not be inhaled. Repellent-treated clothes should be washed, or kept outside living areas to reduce exposure. Following all these precautions reduces risk, but does not eliminate it.

There are a number of effective, less toxic insect repellents available. They need to be applied more frequently than DEET based repellents, but they do not carry the same health risks. Two botanical repellents which performed particularly well in a Florida study were Repel Lemon Eucalyptus Lotion Insect Repellent ( also marketed as FiteBite Plant Based Insect Repellent) which protected for 120 minutes, and Bite Blocker for Kids, a 2% soybean oil formula, which was effective for 95 minutes. Citronella products in the study provided about 30-40 minutes of protection.

Pharmacist Peter Ford in Moncton compounds two pesticide-free insect repellents: GUB lotion, which is vanilla based and well tolerated by chemically sensitive people, and The Citronella Spray. Great Ocean Natural Foods in Halifax stocks a selection of repellents based on essential oils including citronella, teatree and eucalyptus. Citronella, teatree and eucalyptus are volatile oils and may trigger reactions in some people, particularly the chemically sensitive. Bug shirts or hats are an excellent, non-toxic method of protection.

Back yard mosquito control tips: Mosquito coil smoke contains about 70 different volatile organic compounds including allethrin, phenol, benzene, toluene and xylene, all quite toxic especially when burned and inhaled. Using yellow outdoor light bulbs which do not attract insects can help reduce mosquito populations at night. Another option is to use a fan when there is little wind since mosquitoes are not strong flyers. Planting mosquito repelling plants like lemon balm, catnip, basil and lemon geraniums around outdoor sitting areas and encouraging mosquito predators like bats and dragonflies can help reduce mosquito populations.

Edited June 15, 2012 by redroo

[Pseudolus]

Being very clueless on this, but how closely related to Malaria is Dengue? Any at all? Dengue vaccine would be massive but malaria would be proper world news.

[redroo]

Dengue is transmitted by the bite of an Aedes mosquito infected with any one of the four dengue viruses. It occurs in tropical and sub-tropical areas of the world. Symptoms appear 3—14 days after the infective bite. Dengue fever is a febrile illness that affects infants, young children and adults.

Symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. There are no specific antiviral medicines for dengue. It is important to maintain hydration. Use of acetylsalicylic acid (e.g. aspirin) and non steroidal anti-inflammatory drugs (e.g. Ibuprofen) is not recommended.

Dengue haemorrhagic fever (fever, abdominal pain, vomiting, bleeding) is a potentially lethal complication, affecting mainly children. Early clinical diagnosis and careful clinical management by experienced physicians and nurses increase survival of patients.

WORLD HEALTH ORGANIZATION

[redroo]

Aedes mosquitoes typically live indoors and are often found in dark,

cool places such as in closets,

under beds, behind curtains, and in bathrooms.

Long-term travelers and expatriates

can take extra precautions to reduce mosquito-breeding sites around their accommodations

by emptying and cleaning or covering any standing water

(such as in water storage tanks and flowerpot trays).

[cheshiremusicman]

Dangers Of Deet

We are not big fans of Deet as you will find out...

Deet will basically prevent creatures such as mosquitos biting the skin.

Prime Time Live ran an expose on the dangers of DEET on May 31, 1995. Insect repellents containing the chemical DEET are dangerous for human use, but political pressure from major chemical companies confounds attempts to regulate the dangerous ingredient. DEET is considered responsible for side effects including rashes, muscle twitching,confusion, slurred speech, seizures and even death. Most poison reactions to DEET probably go undetected even though nearly 5,000 DEET-related cases are reported each year to the National Centers for Poison Control.

DEET (N,N-diethyl-meta-toluamide) is arguably the most widely recommended active ingredient in insect repellents. DEET does not kill insects. Instead it prevents biting insects like mosquitoes and ticks from zeroing in on your skin.

Biting insects follow the scent of carbon dioxide gas to find a meal. Skin and breath naturally give off a carbon dioxide. By spreading a small amount of DEET on exposed skin and applying it to external clothing, insects cannot readily locate the source of the carbon dioxide.

Older products containing DEET may have had misleading labels that included a child safety claim for concentrations of 15% or less. When the EPA reassessed DEET in 1998 it mandated that the child safety claim be discontinued, finding that the concentration of DEET was irrelevant; following directions was deemed to be critical.

DEET is a registered pesticide. DEET is short for N,N-diethyl-m-toluamide (also known as N,N-diethyl-3-methylbenzamide). It is a member of the toluene chemical family. Toluene is an organic solvent used in rubber and plastic cements and paint removers. DEET is absorbed through the skin and passes into the blood. The Medical Sciences Bulletin, published by Pharmaceutical Information Associates Ltd. reports, "Up to 56% of DEET applied topically penetrates intact human skin and 17% is absorbed into the bloodstream." Blood concentrations of about 3 mg per litre have been reported several hours after DEET repellent was applied to skin in the

prescribed fashion.

DEET is also absorbed by the gut.

The most serious concerns about DEET are its effects on the central nervous system. Dr. Mohammed Abou-Donia of Duke University studied lab animals' performance of neuro-behavioural tasks requiring muscle co-ordination.

He found that lab animals exposed to the equivalent of average human doses of DEET performed far worse than untreated animals. Abou-Donia also found that combined exposure to DEET and permethrin, a mosquito spray ingredient, can lead to motor deficits and learning and memory dysfunction.

An emergency medicine bulletin notes that DEET may have significantly greater toxicity when combined with ethyl and isopropyl alcohols and freon which are components of some DEET repellents. In 1998, the US EPA made it illegal for any product containing DEET to make any child safety claims. Products with DEET are required to carry instructions that they should not be used at all for children under 6 months.

Additional required warnings state that for children 6 months to 2 years, only concentrations of less than 10% DEET should be used, and only once a day. For children from 2 -12 years old, only concentrations under 10% should be used, and repellents should not be applied more than 3 times a day.

For adults, Health Canada has now banned products with DEET concentrations over 30%, citing health risks and evidence that increasing the percentage does not do much more to repel insects. Health Canada has also banned two in one products which combine sunscreen and DEET, saying they create the potential for people be exposed to too much DEET. The ban does not take effect until December 2004, so consumers may want to be careful not to pick up combination products still on store shelves.

Products containing DEET are now required to carry labels which specify:

-Do not apply over cuts, wounds, or irritated skin.

-Do not apply to hands or near eyes and mouth of young children.

-Do not allow young children to apply this product.

-After returning indoors, wash treated skin with soap and water.

-Do not use under clothing.

-Do not spray in enclosed areas.

Experts recommend that if using DEET, its best to wear long sleeves and long pants, when possible, and apply repellent to clothing rather than skin to reduce exposure. They state DEET based products should only be applied sparingly; saturation does not increase efficiency. DEET repellents should not be inhaled. Repellent-treated clothes should be washed, or kept outside living areas to reduce exposure. Following all these precautions reduces risk, but does not eliminate it.

There are a number of effective, less toxic insect repellents available. They need to be applied more frequently than DEET based repellents, but they do not carry the same health risks. Two botanical repellents which performed particularly well in a Florida study were Repel Lemon Eucalyptus Lotion Insect Repellent ( also marketed as FiteBite Plant Based Insect Repellent) which protected for 120 minutes, and Bite Blocker for Kids, a 2% soybean oil formula, which was effective for 95 minutes. Citronella products in the study provided about 30-40 minutes of protection.

Pharmacist Peter Ford in Moncton compounds two pesticide-free insect repellents: GUB lotion, which is vanilla based and well tolerated by chemically sensitive people, and The Citronella Spray. Great Ocean Natural Foods in Halifax stocks a selection of repellents based on essential oils including citronella, teatree and eucalyptus. Citronella, teatree and eucalyptus are volatile oils and may trigger reactions in some people, particularly the chemically sensitive. Bug shirts or hats are an excellent, non-toxic method of protection.

Back yard mosquito control tips: Mosquito coil smoke contains about 70 different volatile organic compounds including allethrin, phenol, benzene, toluene and xylene, all quite toxic especially when burned and inhaled. Using yellow outdoor light bulbs which do not attract insects can help reduce mosquito populations at night. Another option is to use a fan when there is little wind since mosquitoes are not strong flyers. Planting mosquito repelling plants like lemon balm, catnip, basil and lemon geraniums around outdoor sitting areas and encouraging mosquito predators like bats and dragonflies can help reduce mosquito populations.

Dangers Of Deet

We are not big fans of Deet as you will find out...

Deet will basically prevent creatures such as mosquitos biting the skin.

Prime Time Live ran an expose on the dangers of DEET on May 31, 1995. Insect repellents containing the chemical DEET are dangerous for human use, but political pressure from major chemical companies confounds attempts to regulate the dangerous ingredient. DEET is considered responsible for side effects including rashes, muscle twitching,confusion, slurred speech, seizures and even death. Most poison reactions to DEET probably go undetected even though nearly 5,000 DEET-related cases are reported each year to the National Centers for Poison Control.

DEET (N,N-diethyl-meta-toluamide) is arguably the most widely recommended active ingredient in insect repellents. DEET does not kill insects. Instead it prevents biting insects like mosquitoes and ticks from zeroing in on your skin.

Biting insects follow the scent of carbon dioxide gas to find a meal. Skin and breath naturally give off a carbon dioxide. By spreading a small amount of DEET on exposed skin and applying it to external clothing, insects cannot readily locate the source of the carbon dioxide.

Older products containing DEET may have had misleading labels that included a child safety claim for concentrations of 15% or less. When the EPA reassessed DEET in 1998 it mandated that the child safety claim be discontinued, finding that the concentration of DEET was irrelevant; following directions was deemed to be critical.

DEET is a registered pesticide. DEET is short for N,N-diethyl-m-toluamide (also known as N,N-diethyl-3-methylbenzamide). It is a member of the toluene chemical family. Toluene is an organic solvent used in rubber and plastic cements and paint removers. DEET is absorbed through the skin and passes into the blood. The Medical Sciences Bulletin, published by Pharmaceutical Information Associates Ltd. reports, "Up to 56% of DEET applied topically penetrates intact human skin and 17% is absorbed into the bloodstream." Blood concentrations of about 3 mg per litre have been reported several hours after DEET repellent was applied to skin in the

prescribed fashion.

DEET is also absorbed by the gut.

The most serious concerns about DEET are its effects on the central nervous system. Dr. Mohammed Abou-Donia of Duke University studied lab animals' performance of neuro-behavioural tasks requiring muscle co-ordination.

He found that lab animals exposed to the equivalent of average human doses of DEET performed far worse than untreated animals. Abou-Donia also found that combined exposure to DEET and permethrin, a mosquito spray ingredient, can lead to motor deficits and learning and memory dysfunction.

An emergency medicine bulletin notes that DEET may have significantly greater toxicity when combined with ethyl and isopropyl alcohols and freon which are components of some DEET repellents. In 1998, the US EPA made it illegal for any product containing DEET to make any child safety claims. Products with DEET are required to carry instructions that they should not be used at all for children under 6 months.

Additional required warnings state that for children 6 months to 2 years, only concentrations of less than 10% DEET should be used, and only once a day. For children from 2 -12 years old, only concentrations under 10% should be used, and repellents should not be applied more than 3 times a day.

For adults, Health Canada has now banned products with DEET concentrations over 30%, citing health risks and evidence that increasing the percentage does not do much more to repel insects. Health Canada has also banned two in one products which combine sunscreen and DEET, saying they create the potential for people be exposed to too much DEET. The ban does not take effect until December 2004, so consumers may want to be careful not to pick up combination products still on store shelves.

Products containing DEET are now required to carry labels which specify:

-Do not apply over cuts, wounds, or irritated skin.

-Do not apply to hands or near eyes and mouth of young children.

-Do not allow young children to apply this product.

-After returning indoors, wash treated skin with soap and water.

-Do not use under clothing.

-Do not spray in enclosed areas.

Experts recommend that if using DEET, its best to wear long sleeves and long pants, when possible, and apply repellent to clothing rather than skin to reduce exposure. They state DEET based products should only be applied sparingly; saturation does not increase efficiency. DEET repellents should not be inhaled. Repellent-treated clothes should be washed, or kept outside living areas to reduce exposure. Following all these precautions reduces risk, but does not eliminate it.

There are a number of effective, less toxic insect repellents available. They need to be applied more frequently than DEET based repellents, but they do not carry the same health risks. Two botanical repellents which performed particularly well in a Florida study were Repel Lemon Eucalyptus Lotion Insect Repellent ( also marketed as FiteBite Plant Based Insect Repellent) which protected for 120 minutes, and Bite Blocker for Kids, a 2% soybean oil formula, which was effective for 95 minutes. Citronella products in the study provided about 30-40 minutes of protection.

Pharmacist Peter Ford in Moncton compounds two pesticide-free insect repellents: GUB lotion, which is vanilla based and well tolerated by chemically sensitive people, and The Citronella Spray. Great Ocean Natural Foods in Halifax stocks a selection of repellents based on essential oils including citronella, teatree and eucalyptus. Citronella, teatree and eucalyptus are volatile oils and may trigger reactions in some people, particularly the chemically sensitive. Bug shirts or hats are an excellent, non-toxic method of protection.

Back yard mosquito control tips: Mosquito coil smoke contains about 70 different volatile organic compounds including allethrin, phenol, benzene, toluene and xylene, all quite toxic especially when burned and inhaled. Using yellow outdoor light bulbs which do not attract insects can help reduce mosquito populations at night. Another option is to use a fan when there is little wind since mosquitoes are not strong flyers. Planting mosquito repelling plants like lemon balm, catnip, basil and lemon geraniums around outdoor sitting areas and encouraging mosquito predators like bats and dragonflies can help reduce mosquito populations.

Thank you for this very interesting and informative information. I really didn't realise just how dangerous 'Deet' was; now I know, I shall use it very very sparingly.

When I was in India I was told that the oil from the 'Neen' tree, that they call here in Thailand the 'Sadoa tree' was also a very good mosquito repellent. It has many uses in Ayurvedic Medicine including the treatment of colonic infections; something that I was particularly glad to find out when a friend of mine was diagnosed with 'Diveriticulitus'. He took 3 capsules 3 times a day for 6 months and amazed the specialists by making a full recovery; this after being told that there was NO treatment s and he could end up having colonic surgery. His own doctor took up this treatment and recommended it to some of his patients and out of 16 of them 12 made complete recoveries and the other 4 reported having very minor symptoms after 6 months. There is a company in South Wales (UK) that supplies both capsules,oils and infusions at very reasonable costs; whereas here in Thailand you can take the leaves off the trees that grow wild and dry them naturally, before crushing them in a mortar and pestle and making an infusion from this; it is extremely bitter . Another use is the 'fruit' from the tree. If this is lightly crushed and thrown into ponds it is reputed to kill mosquito larva. I just wonder why it is not used here in Thailand. I can understand that the Pharmaceutical companies would have no interest in this as they could not patent it, so no profit. There have been reports recently that this is also being researched as a possible cure for some forms of cancer; let us all hope that this turns out to be true. I have seen pictures taken in India where locust have ravaged whole areas and the only thing that they will not touch is the Neem or Sadoa tree.

I have been trying to buy Sadoa oil here in Thailand , but as of now I have had no luck. If anybody has any info as to where I can buy it I would be most interested.

[TallGuyJohninBKK]

This below looks like the results of the dengue vaccine study promised above:

Mixed results reported on dengue vaccine

Sabchareon A. Lancet. 2012;doi:10.1016/S0140-6736(12)61428-7.

• September 14, 2012
  

A prevalent type of dengue in Thailand eluded a vaccine designed to prevent against it, but results of the vaccine against other serotypes show that vaccination against dengue is possible, according to study results published online.

Researchers from Sanofi-Pasteur reported results of a study that was conducted in 4,002 children aged 4 to 11 years, in partnership with the Mahidol University under the patronage of the Thai Ministry of Public Health. Sanofi-Pasteur’s dengue vaccine candidate is a live-attenuated vaccine. The vaccination schedule is three doses given 6 months apart, at 0, 6 and 12 months.

The full analysis of vaccine efficacy against each serotype, in an intent-to-treat analysis, showed vaccine efficacy to be 61.2% against dengue virus type 1, 81.9% against type 3 and 90% against type 4. Serotype 2 eluded the vaccine, researchers said. Analyses are ongoing to understand the lack of protection for serotype 2 in the particular epidemiological context of Thailand.

“While there is still much work to be done, these clinical trials mark a decisive step forward in the development of a safe and effective vaccine,” said Luiz da Silva, director of the Dengue Vaccine Initiative, said in a press release. “We support the progress made by Sanofi-Pasteur, as well as efforts by other organizations, to deliver a vaccine to populations in endemic countries.”

A feature of dengue epidemiology is that the relative prevalence of virus types in a given area is evolving with time. Phase 3 clinical studies of Sanofi-Pasteur’s dengue vaccine candidate are under way, with 31,000 children and adolescents in 10 countries in Asia and Latin America. These studies will generate important additional data in a broader population and in a variety of epidemiological settings to define the best conditions to set up vaccination programs to protect people at risk for dengue.

The FDA has granted fast-track designation to Sanofi’s investigational dengue vaccine. The FDA fast-track designation recognizes that a dengue vaccine would address an important unmet medical need for serious disease.

Disclosure: The study was funded by Sanofi-Pasteur.

http://www.healio.co...-dengue-vaccine

Edited September 22, 2012 by TallGuyJohninBKK

[redroo]

1 ibuprofin 400mg nearly killed me ,because i thought i had the flu virus.

15 minutes later i was unable to breath properly and started to pass out.

made it out the door and luckely the hospitals door just across the road ,

passed out from the lack off oxygen got put on a streacher and given oxygen

and slowly came back to normal.had my blood taken wich revealed i had

dengue !

also don't let them give you parracetamol after or together with ibuprofin!

bad idear.

[cowslip]

Being very clueless on this, but how closely related to Malaria is Dengue? Any at all? Dengue vaccine would be massive but malaria would be proper world news.

not related - Dengue is a virus and Malaria is a parasite. THey are carried by mosquitoes. Dengue thrives in relatively densely populated areas.e.g. Urban areas.

[cowslip]

THe normal advice is never take aspirin of blood-thinning drugs with Dengue and there is the potential risk of haemorrhaging.

These trials while hopeful have to be scrutinised by peers and the tests may need to be shown to be repeatable before we can say for certain they are the good news we want them to be.

[Curt1591]

These trials while hopeful have to be scrutinised by peers and the tests may need to be shown to be repeatable before we can say for certain they are the good news we want them to be.

Send it to the USA's FDA. It shoud only be about ten years to have it approved!

[cowslip]

These trials while hopeful have to be scrutinised by peers and the tests may need to be shown to be repeatable before we can say for certain they are the good news we want them to be.

Send it to the USA's FDA. It shoud only be about ten years to have it approved!

i think you should bear in mind the necessary processes of medical trials and the proof required. Although I'm sure the FDA is in itself an over bureaucratic institution, there are other countries outside the States with scientists and Labs capable of verifying these results. There is no point in administering this vaccine without solid, verifiable evidence that it works and is free of harmful side effects. I sincerely hope this is the case and that the vaccine will be available to adults too.

[TallGuyJohninBKK]

I always "enjoy" it when the U.S. FDA approves some new drug or injection...and then a few years later ends up issuing some health warning about how that treatment can kill people and thus needs to be taken off the market or otherwise significantly restricted.

Clearly there are diseases and such out there in the world that are crying out for some effective treatment. But sometimes the rush to a supposed remedy can end up being deadly as well. Caution is always warranted with experimental or new treatments/vaccines.