Some people DO win the lottery in terms of their genetic inheritance, they are called statistical outliers.
There's a saying in quality control, if you don't measure it, you can't control it. I have no problem with regular health checks, because then I may be able to do something about a parameter which is abnormal. I'd rather know about a problem than ignore it, for my own peace of mind. And as Sheryl has said, always best to treat cancer early.
Having regular colonoscopies was recommended for me because I had an uncle who died of bowel cancer. As no one else in a pretty extensive family has had it, it's probably fair to say his might have been a result of lifestyle or environment, not genetics.
We are entirely on the same page as far as pharmaceuticals go. I am living proof, as I have dispensed with 5 pills I was taking 6 years ago. I no longer need them, due to a combination of diet and exercise. The measurements I do verify stopping them is valid.
As a bonus, I have also retreated from the precipice of Type 2 diabetes, would probably be taking another pill if I had not.