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Thailand battles drug-resistant malaria strains that imperil global campaign

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On 12/17/2017 at 7:33 AM, Airbagwill said:

"A person  infected  by the   new  strain  who  is  bitten  by and thus creates  a vector carrier   mosquito  that then infects   new   victims...

So sitting next  to an infected  person  while  in the  presence  of  mosquitoes who  are   feeding  on  both  of  you   is  not  so far  removed  from  direct transmission. Admittedly there  is  actually a  time  span   that is  required   for  the   mosquito  to   actually  pass on  the infection it but  amounts  to the  same  thing. Previous  strains have  been  curable  but  resistant  strains  not  easily. 

There  is  an  existing  proposal  to  genetically   alter  mosquitoes  to  prevent  thier  capacity  to  carry  the  disease. Curiously  or  not  it  has  never been  adopted  as a  world  health  strategy. Treatment  rather than cure  probably  has  an economic  windfall  that  over rides  the  effectiveness despite  the  misery it  causes  to  millions  of (which  decile ? ) people."

 

Dumbastheycome - I think you are misinformed about the way that the parasites are transmitted.

 

Malarial parasites have 2 life cycles.

In humans they live in liver and blood but can produce further organisms that increase damage to their human host.

 

For a person to be infected initially, they have to be bitten by a mozzie cpble of transmitting the disease. To do this the mosquito has to ingest blood from an infected human.......then it takes 10 to 18 days from ingestion to getting to the mozzies salivary glands.  (as "sporozoites") - it is only then that the parasites can be successfully injected into another human.

 

Furthermore only the female mosquito needs blood meals and these are taken only once or twice a day.

 

So being near a malarial patient doesn’t bear the risk of immediate “direct” infection as the mosquito would need up to 18 days to be able to transfer the parasite. The risk would be about the same in any malarial area regardless of proximity of humans.

 

The frequency of mozzies biting habits and the time taken for the parasite to develop in the mosquito mean that a mozzie can't just hop from one person to another and spread the disease.

.  That is  why I  mention a  time  span. However  that  does  not  negate  the risk  if  in an area  of and in the  company  of an already infected  person. The  problem  with  even  minor  endemic  transmission  is  that  by the time  the  first  case  is  identified there is  the potential  for  many   more  to follow .That  is often clearly  statistically demonstrated by episodes  of infection  not limited to  malaria.

The   female  Anopheles mosquito can live as  long as   one  month  if  conditions  suit. Which  even for a  single  insect  that  acquires   malarial infection  capacity  represents a very    large  window  of  victim  potential.

Which  means  that  if you are in the presence  of  a  malaria   victim  in your  usual  vicinity  of  residence then  you  are  at  very increased  risk  of becoming another  victim, indirectly.

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On 12/16/2017 at 12:10 PM, Chris Lawrence said:

Malaria is not spread from person to person like a cold or the flu, and it cannot be sexually transmitted. You cannot get malaria from casual contact with malaria-infected people, such as sitting next to someone who has malaria. CDC web site.

 

So what is this fellow implying?

 

Its a terrible disease. A few guys at boarding school got a reoccurrence of Malaria. They were sick for about 5 days, fever and sore.

 

 

True - malaria is not spread person-to-person.  However if someone who is infected with the new strain of malaria passes from one country to another then there is a possibility of that person being bitten by a mosquito in the second country and thus develops the new resistant strain of the malarial parasite.

 

This is why someone entering an Asian country from a yellow fever infected area has to have had the Yellow Fever vaccine at least 10 days prior to entering the Asian country and some other countries where the anopheles mosquito is present.

On 12/16/2017 at 8:33 PM, fandango71 said:

 

I guess the fellow is implying that if somebody who is infected with the resistant strain travels to an area that does not yet have that resistant strain they could then be bitten by a mosquito that could then acquire that resistant strain. 

 

That mosquito could then go on to bite and infect other people in that area who could then be bitten by other mosquitoes that could also acquire the resistant strain and so on and so on until the new resistant strain becomes established in the area that didn't previously have it.

 

I am no expert but it's kinda scary if that is how it does spread.

Travellers do spread malaria but the chances of an individual doing do are quite sounds as they have to go (home?) to an area that has sufficient numbers if the malarial vector mosquito to bite that person successfully and then transmit the parasite to another person. The right mozzies have to be present though.

On 12/18/2017 at 9:12 PM, Dumbastheycome said:

.  That is  why I  mention a  time  span. However  that  does  not  negate  the risk  if  in an area  of and in the  company  of an already infected  person. The  problem  with  even  minor  endemic  transmission  is  that  by the time  the  first  case  is  identified there is  the potential  for  many   more  to follow .That  is often clearly  statistically demonstrated by episodes  of infection  not limited to  malaria.

The   female  Anopheles mosquito can live as  long as   one  month  if  conditions  suit. Which  even for a  single  insect  that  acquires   malarial infection  capacity  represents a very    large  window  of  victim  potential.

Which  means  that  if you are in the presence  of  a  malaria   victim  in your  usual  vicinity  of  residence then  you  are  at  very increased  risk  of becoming another  victim, indirectly

The intitial premise was this, which is not accurate.... "So sitting next  to an infected  person  while  in the  presence  of  mosquitoes who  are   feeding  on  both  of  you   is  not  so far  removed  from  direct transmission."

All you have described later is the situation regarding a  high risk malarial region.

Edited by Airbagwill

On 12/21/2017 at 8:16 AM, Airbagwill said:

The intitial premise was this, which is not accurate.... "So sitting next  to an infected  person  while  in the  presence  of  mosquitoes who  are   feeding  on  both  of  you   is  not  so far  removed  from  direct transmission."

All you have described later is the situation regarding a  high risk malarial region.

Up to  you then.  Being  seated  with a  person infected  by  a mosquito that may still be  present up to  30  days while  the onset  of   malaria  symptoms  can be as  short as  7  days obviously has  no  significance.

A further aside to all of this.  It is the female mosquito which carries the malarial  parasite, of the females only 2% carry the parasite.  In theory, if the mossie population is split 50-50 males to females, therefore you could be bitten 99 times and not develop malaria until the 100th gets you.  Mind you though, it could be the first bite!!!!

 

Dont know about the Dengue carrying mossies though, which is more of a concern in this country

On ‎12‎/‎16‎/‎2017 at 10:04 AM, Airbagwill said:

Really? We managed to eradicate smallpox.

That was easy as it can be prevented by vaccination. No vaccination for malaria.

11 minutes ago, Nurseynutcase said:

A further aside to all of this.  It is the female mosquito which carries the malarial  parasite, of the females only 2% carry the parasite.  In theory, if the mossie population is split 50-50 males to females, therefore you could be bitten 99 times and not develop malaria until the 100th gets you.  Mind you though, it could be the first bite!!!!

 

Dont know about the Dengue carrying mossies though, which is more of a concern in this country

Further, if a mossie bites someone with malaria before biting you it's probably a given you get malaria.

No people with malaria around and it's unlikely that you will be infected.

I must have been lucky as got bitten a lot.

Think I had dengue 3 times though.

37 minutes ago, thaibeachlovers said:

Further, if a mossie bites someone with malaria before biting you it's probably a given you get malaria.

No people with malaria around and it's unlikely that you will be infected.

I must have been lucky as got bitten a lot.

Think I had dengue 3 times though.

Is that correct?

 

A mossie bites someone with malaria can then pass that malaria on to someone else?

 

Genuinely didn’t know that was the case. 

 

I thought it was passed on through their larvae or something like that. 

 

Edited by Bluespunk

6 hours ago, Bluespunk said:

Is that correct?

 

A mossie bites someone with malaria can then pass that malaria on to someone else?

 

Genuinely didn’t know that was the case. 

 

I thought it was passed on through their larvae or something like that. 

 

Yes. It  is  correct.  But... if  the  mosquito   was  not  already   a  vector  it  takes  a  wile  for it to  become so.

But it is   possible  that  the  same  mosquito  that  infected  another  in  your  residential vicinity can pass  that same infection  to  you having   acquired  it  from that  individual  or  another  previous  source.

There  are  variants  of   malaria  and  also  variants  of .incubation   times  and  onset  of   symptoms .

Infection  simply  by  being  in  the presence  of  a  malaria  sufferer has  no  direct  communicable  risk other  than that  if  the   mosquito/s that infected the  victim in  your  presence is still also present.

Communicable  infection other  than  by  direct  contact such as  STD's  mostly  require  a  vector.

In the  case  of  the  common  cold  or  influenza  for  example it  is  mostly   by the   ignored  vector.....air....due  to a  sneeze  or  a  cough.

In that  sense  acquiring   malaria by  being in  the  presence  of  both an infected  person and  a  vector   mosquito can  indirectly    yet  directly  have  the potential   to  extend that  infection  to  new  victims.

So the  most  obvious solution  is  to  eliminate/avoid  the  vector in the  case  of   malaria,  dengue,  yellow   fever  etc.

An aside  issue of  concern is  that there  is some  evidence that  dengue can  be  passed  to  new   generations of  mosquito from an infected  carrier parent which  massively  increases  potential transmission. If  that  is proven  along  with  the  adaptability  of  the   carrier   tropical mosquito  to  survive in sub  tropical  climates then it  can only  be  hoped  that  the   mosquito  that transmits  malaria does  not /has not  also  adapt similarly.

 

 

 

 

 

 

13 hours ago, thaibeachlovers said:

That was easy as it can be prevented by vaccination. No vaccination for malaria.

There is already a partially effective vaccination for malaria

Edited by Airbagwill

13 hours ago, thaibeachlovers said:

Further, if a mossie bites someone with malaria before biting you it's probably a given you get malaria.

No people with malaria around and it's unlikely that you will be infected.

I must have been lucky as got bitten a lot.

Think I had dengue 3 times though.

Not really ..only a small percentage actually carry the disease and it takes days before the parasite can be transmitted. The female only feeds (therefore bites) about once a week.

It now appears that the density of parasites in the mosquitos' saliva it directly related to the chances of transmission.

"When a mosquito bites an infected person, a small amount of blood is taken in which contains microscopic malaria parasites. About 1 week later, when the mosquito takes its next blood meal, these parasites mix with the mosquito's saliva and are injected into the person being bitten". - Canadian Govt advice.

On 12/22/2017 at 5:52 PM, Dumbastheycome said:

Up to  you then.  Being  seated  with a  person infected  by  a mosquito that may still be  present up to  30  days while  the onset  of   malaria  symptoms  can be as  short as  7  days obviously has  no  significance.

You need to inform yourself of the number of times the female feeds, the time required for the parasite to develop and pass into the mosquito's salivary gland and how the variation of density of parasites in the saliva affects the probability of transmission as well as the probable.percentage of infected females at any one time.

All this makes sitting next to person with Malaria risk free. The risk is determined by the risk in the region not by where you are sitting....You will be at the same risk where ever you are. 

Edited by Airbagwill

On 12/18/2017 at 9:12 PM, Dumbastheycome said:

.  That is  why I  mention a  time  span. However  that  does  not  negate  the risk  if  in an area  of and in the  company  of an already infected  person. The  problem  with  even  minor  endemic  transmission  is  that  by the time  the  first  case  is  identified there is  the potential  for  many   more  to follow .That  is often clearly  statistically demonstrated by episodes  of infection  not limited to  malaria.

The   female  Anopheles mosquito can live as  long as   one  month  if  conditions  suit. Which  even for a  single  insect  that  acquires   malarial infection  capacity  represents a very    large  window  of  victim  potential.

Which  means  that  if you are in the presence  of  a  malaria   victim  in your  usual  vicinity  of  residence then  you  are  at  very increased  risk  of becoming another  victim, indirectly.

It is not physically possible for a mosquito to transmit malaria to you from a person you are sitting next to.

17 hours ago, Bluespunk said:

Is that correct?

 

A mossie bites someone with malaria can then pass that malaria on to someone else?

 

Genuinely didn’t know that was the case. 

 

I thought it was passed on through their larvae or something like that. 

 

It is my understanding that a mosquito has to suck the blood of an infected person to be able to pass it on.

 

Perhaps I'll leave it to the internet to explain better

http://www.telegraph.co.uk/news/worldnews/africaandindianocean/11760204/What-is-malaria-and-how-is-it-transmitted.html

The process begins when a female mosquito carrying the disease feeds on a human.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

 The next time a mosquito bites an infected person, the disease is transferred through their blood, and the deadly cycle starts all over again.

2 minutes ago, thaibeachlovers said:

It is my understanding that a mosquito has to suck the blood of an infected person to be able to pass it on.

 

Perhaps I'll leave it to the internet to explain better

http://www.telegraph.co.uk/news/worldnews/africaandindianocean/11760204/What-is-malaria-and-how-is-it-transmitted.html

The process begins when a female mosquito carrying the disease feeds on a human.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

 The next time a mosquito bites an infected person, the disease is transferred through their blood, and the deadly cycle starts all over again.

Maybe my post was poorly worded,  but I was asking if the ability to pass on malaria begins immediately after a mossie bites an infected person. 

 

As in, the infection can be passed on by the mossie within minutes of it biting an infected person. 

Edited by Bluespunk

20 minutes ago, Bluespunk said:

Maybe my post was poorly worded,  but I was asking if the ability to pass on malaria begins immediately after a mossie bites an infected person. 

 

As in, the infection can be passed on by the mossie within minutes of it biting an infected person. 

No. The  mosquito does  not  pass the infection that way. But the  same  mosquito that infected  the other person can also infect you.  

5 hours ago, Airbagwill said:

It is not physically possible for a mosquito to transmit malaria to you from a person you are sitting next to.

Nor have I  said otherwise.

6 hours ago, Airbagwill said:

There is already a partially effective vaccination for malaria

Could you enlighten me on this?  Also for which type of malaria?

 

I am aware that much research has been going on to find one, but was not aware that one has already been developed and is in use.

 

Many thanks

10 hours ago, Bluespunk said:

Maybe my post was poorly worded,  but I was asking if the ability to pass on malaria begins immediately after a mossie bites an infected person. 

 

As in, the infection can be passed on by the mossie within minutes of it biting an infected person. 

Perhaps my post was also poorly worded.

I should have said more along the lines of "if in an area with high levels of malaria, the chances of becoming infected if bitten are high, but as I live in an area with low levels ( if any ) of malaria, I've been bitten many times without becoming infected".

It's worth noting that I saw many years ago in the big hospital in Bkk that malarial prophylaxis is ineffective in Thailand.

9 hours ago, Nurseynutcase said:

Could you enlighten me on this?  Also for which type of malaria?

 

I am aware that much research has been going on to find one, but was not aware that one has already been developed and is in use.

 

Many thanks

http://www.who.int/immunization/research/development/malaria/en/

"The parasite strains are spreading quite quickly at the moment through Cambodia to the neighboring countries," said Arjen Dondorp, the head of malaria research at Mahidol-Oxford's Tropical Medicine unit in Thailand.

 

That's indeed very scary when you've got to trust your local doctors at the hospital. 

On 12/24/2017 at 11:13 AM, Nurseynutcase said:

Could you enlighten me on this?  Also for which type of malaria?

 

I am aware that much research has been going on to find one, but was not aware that one has already been developed and is in use.

 

Many thanks

Read the WHO literature and get up to speed.

On 12/24/2017 at 10:32 AM, Dumbastheycome said:

No. The  mosquito does  not  pass the infection that way. But the  same  mosquito that infected  the other person can also infect you.  

It takes 10 to 18 days for the parasite to enter the movie's salivary glands and the female mozzie eats about once a week......you'll have to hang around for sometime to get infected by the same mozzie.

On 12/24/2017 at 10:37 AM, Dumbastheycome said:

Nor have I  said otherwise.

Seriously? - "So sitting next  to an infected  person  while  in the  presence  of  mosquitoes who  are   feeding  on  both  of  you   is  not  so far  removed  from  direct transmission" - these are your words.

 

Edited by Airbagwill

22 hours ago, Airbagwill said:

Seriously? - "So sitting next  to an infected  person  while  in the  presence  of  mosquitoes who  are   feeding  on  both  of  you   is  not  so far  removed  from  direct transmission" - these are your words.

 

You  have  suggested  I  need  to  inform  myself  of   etc  etc.  Can  you,  having  declared  "zero  risk "  by  being  in the  company of a  person  who  is   suffering   malarial  infection seriously  deny what  I  have  suggested is  not  real?

I am  informed  well enough of  the  time  period  for  the  acquistion for transmission of  malaria by a   mosquito,  its  nominal  life  cycle,  and  the  the  onset of   symptoms  by a  human   victim.

I  stand  by  my  statement  of  opinion  that sitting  next  to a  person ..... does  indeed  invite  risk not  so  far removed  from  direct  transmission. 

NOT  direct  but  not so far  from in that  being  in a  malarial  environment  and  in the  possible  presence  of   the  same   mosquito  that  infected  the  initial  victim or even the  next  generation  of   mosquito who has  also  bitten  that same victim. The  time  frames for  transmission make  that a  possibility.

Complacency in  the  face  of  potential  risk ?.

I  would  not  avoid  the  person I  sat  next  to. But I would   definitely   avoid  any  chance  of  being  bitten by  any   mosquito  in  that  or  any other   vicinity!

 

8 hours ago, Dumbastheycome said:

You  have  suggested  I  need  to  inform  myself  of   etc  etc.  Can  you,  having  declared  "zero  risk "  by  being  in the  company of a  person  who  is   suffering   malarial  infection seriously  deny what  I  have  suggested is  not  real?

I am  informed  well enough of  the  time  period  for  the  acquistion for transmission of  malaria by a   mosquito,  its  nominal  life  cycle,  and  the  the  onset of   symptoms  by a  human   victim.

I  stand  by  my  statement  of  opinion  that sitting  next  to a  person ..... does  indeed  invite  risk not  so  far removed  from  direct  transmission. 

NOT  direct  but  not so far  from in that  being  in a  malarial  environment  and  in the  possible  presence  of   the  same   mosquito  that  infected  the  initial  victim or even the  next  generation  of   mosquito who has  also  bitten  that same victim. The  time  frames for  transmission make  that a  possibility.

Complacency in  the  face  of  potential  risk ?.

I  would  not  avoid  the  person I  sat  next  to. But I would   definitely   avoid  any  chance  of  being  bitten by  any   mosquito  in  that  or  any other   vicinity!

 

Then you are flying in the face of the facts.

13 hours ago, Airbagwill said:

Then you are flying in the face of the facts.

Facts? Or  complacent disinformation?

 

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