placeholder Posted November 5, 2021 Share Posted November 5, 2021 (edited) Covid Live Updates: Pfizer Says Its Antiviral Pill Is Highly Effective Pfizer announced on Friday that its pill to treat Covid-19 had been found in a key clinical trial to be highly effective at preventing severe illness among at-risk people who received the drug soon after they exhibited symptoms. Pfizer’s pill, which will be sold under the brand name Paxlovid, cut the risk of hospitalization or death by 89 percent when given within three days of the start of symptoms. Pfizer said an independent board of experts monitoring its clinical trial had recommended that the study be stopped early because the drug’s benefit to patients had proved so convincing. https://www.nytimes.com/live/2021/11/05/world/covid-delta-variant-vaccine Like Mercks. though, it has to be given early on, apparently, for it to be effective. Likewise for the monoclonal antibody treatment from Regeneron. So, getting vaccinated is still a better option. As for cost, I'm sure it will be a lot more than the $4 for a complete course of fluvoxamine, but I suspect the side effects won't be as difficult to endure. At least in respect to the dosage currently formulated for fluvoxamine. Edited November 5, 2021 by placeholder 1 Link to comment Share on other sites More sharing options...
Someone Else Posted November 5, 2021 Share Posted November 5, 2021 Link is paywalled...I'm curious about the details behind why they say it's more efficacious than Merck's? Link to comment Share on other sites More sharing options...
placeholder Posted November 5, 2021 Author Share Posted November 5, 2021 3 minutes ago, Someone Else said: Link is paywalled...I'm curious about the details behind why they say it's more efficacious than Merck's? Here's a link to a different site: https://www.forbes.com/sites/alexknapp/2021/11/05/pfizer-says-its-covid-pill-reduced-risk-of-hospitalization-and-death-by-89-in-clinical-study/?sh=6909c3f856be Link to comment Share on other sites More sharing options...
placeholder Posted November 5, 2021 Author Share Posted November 5, 2021 4 minutes ago, Someone Else said: Link is paywalled...I'm curious about the details behind why they say it's more efficacious than Merck's? Because it seems to be more effective than molnuprovir: Covid-19: Molnupiravir reduces risk of hospital admission or death by 50% in patients at risk, MSD reports https://www.bmj.com/content/375/bmj.n2422 Link to comment Share on other sites More sharing options...
Someone Else Posted November 5, 2021 Share Posted November 5, 2021 5 minutes ago, placeholder said: Because it seems to be more effective than molnuprovir: Covid-19: Molnupiravir reduces risk of hospital admission or death by 50% in patients at risk, MSD reports https://www.bmj.com/content/375/bmj.n2422 Not seeing any statements about superior efficacy in either link, nor has a comparator study been performed. All I see is two completely separate studies. Link to comment Share on other sites More sharing options...
placeholder Posted November 5, 2021 Author Share Posted November 5, 2021 49 minutes ago, Someone Else said: Not seeing any statements about superior efficacy in either link, nor has a comparator study been performed. All I see is two completely separate studies. Given that the results were so good that the trial was stopped prematurely, I'd say it's a pretty safe bet. But it could turn out not to be. Link to comment Share on other sites More sharing options...
Gottfrid Posted November 5, 2021 Share Posted November 5, 2021 22 minutes ago, placeholder said: Given that the results were so good that the trial was stopped prematurely, I'd say it's a pretty safe bet. But it could turn out not to be. Are you engaging in affiliation? Link to comment Share on other sites More sharing options...
Popular Post JustAnotherHun Posted November 5, 2021 Popular Post Share Posted November 5, 2021 Statements and "studies" made by Pfizer are nearly as credible as statements from Thai officials. https://www.bmj.com/content/375/bmj.n2635 3 Link to comment Share on other sites More sharing options...
placeholder Posted November 5, 2021 Author Share Posted November 5, 2021 6 minutes ago, JustAnotherHun said: Statements and "studies" made by Pfizer are nearly as credible as statements from Thai officials. https://www.bmj.com/content/375/bmj.n2635 One independent contractor hired by Pfizer but not Pfizer itself. Link to comment Share on other sites More sharing options...
JustAnotherHun Posted November 5, 2021 Share Posted November 5, 2021 7 minutes ago, placeholder said: One independent contractor hired by Pfizer but not Pfizer itself. Pfizer used the "study". And if you're interested in the long list of Pfizer scandals, Google will be your friend. 2 Link to comment Share on other sites More sharing options...
placeholder Posted November 5, 2021 Author Share Posted November 5, 2021 1 minute ago, JustAnotherHun said: Pfizer used the "study". And if you're interested in the long list of Pfizer scandals, Google will be your friend. And if you're interested in comparing death and hospitalijzation rates from those who have been vaccinated with the Pfizer vaccine and those who have not...oh wait...clearly you're not interested. Link to comment Share on other sites More sharing options...
Scott Posted November 5, 2021 Share Posted November 5, 2021 Off-topic posts removed along with replies. Link to comment Share on other sites More sharing options...
Bkk Brian Posted November 5, 2021 Share Posted November 5, 2021 Interesting comparison here, not official but it is from an expert: My summary table comparing the new and highly effective anti-Covid pills, a vital step forward for prevailing over the pandemic No head-to-head trial to know about true comparative efficacy, but key differences in mechanism and other features https://twitter.com/EricTopol/status/1456622941647478796 Link to comment Share on other sites More sharing options...
mtls2005 Posted November 6, 2021 Share Posted November 6, 2021 Just to be clear, this is a treatment. And this treatment includes secondary HIV med, Ritonavir. Link to comment Share on other sites More sharing options...
Danderman123 Posted November 9, 2021 Share Posted November 9, 2021 https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext Another positive clinical trial for fluvoxamine. Link to comment Share on other sites More sharing options...
rodknock Posted November 9, 2021 Share Posted November 9, 2021 the first thing is you need a sars-cov-2 test! so you have to be sick first to get THE pill. does that person need to be quarantined?? stay home with the family or go to a hospital?? Link to comment Share on other sites More sharing options...
Atlantis Posted November 10, 2021 Share Posted November 10, 2021 @JustAnotherHun "Revelations of poor practices at a contract research company helping to carry out Pfizer’s pivotal covid-19 vaccine trial raise questions about data integrity and regulatory oversight." “After repeatedly notifying Ventavia of these problems, the regional director, Brook Jackson, emailed a complaint to the US Food and Drug Administration (FDA). Ventavia fired her later the same day. " "When it comes to the FDA and clinical trials, Elizabeth Woeckner, president of Citizens for Responsible Care and Research Incorporated (CIRCARE),3 says the agency’s oversight capacity is severely under-resourced. If the FDA receives a complaint about a clinical trial, she says the agency rarely has the staff available to show up and inspect. And sometimes oversight occurs too late.” "In recent months Jackson has reconnected with several former Ventavia employees who all left or were fired from the company. One of them was one of the officials who had taken part in the late September meeting. In a text message sent in June the former official apologised, saying that “everything that you complained about was spot on.” 1 Link to comment Share on other sites More sharing options...
Atlantis Posted November 10, 2021 Share Posted November 10, 2021 “ Two former Ventavia employees spoke to The BMJ anonymously for fear of reprisal and loss of job prospects in the tightly knit research community. Both confirmed broad aspects of Jackson’s complaint. One said that she had worked on over four dozen clinical trials in her career, including many large trials, but had never experienced such a “helter skelter” work environment as with Ventavia on Pfizer’s trial. “I’ve never had to do what they were asking me to do, ever,” she told The BMJ. “It just seemed like something a little different from normal—the things that were allowed and expected.” She added that during her time at Ventavia the company expected a federal audit but that this never came.” @JustAnotherHun Thank you for bringing to attention actual and relevant faults related to Pfizer from the recent past. You would think that everyone would find your link informative in adjusting their confidence in the company’s claims, if even just a little. But no, topic gets immediately turned to the tiresome go-to refrain along the lines of “But don’t you know how well the vaccines work?!” 1 Link to comment Share on other sites More sharing options...
placeholder Posted November 11, 2021 Author Share Posted November 11, 2021 5 hours ago, Atlantis said: “ Two former Ventavia employees spoke to The BMJ anonymously for fear of reprisal and loss of job prospects in the tightly knit research community. Both confirmed broad aspects of Jackson’s complaint. One said that she had worked on over four dozen clinical trials in her career, including many large trials, but had never experienced such a “helter skelter” work environment as with Ventavia on Pfizer’s trial. “I’ve never had to do what they were asking me to do, ever,” she told The BMJ. “It just seemed like something a little different from normal—the things that were allowed and expected.” She added that during her time at Ventavia the company expected a federal audit but that this never came.” @JustAnotherHun Thank you for bringing to attention actual and relevant faults related to Pfizer from the recent past. You would think that everyone would find your link informative in adjusting their confidence in the company’s claims, if even just a little. But no, topic gets immediately turned to the tiresome go-to refrain along the lines of “But don’t you know how well the vaccines work?!” Texas study: Unvaccinated people are 20 times more likely to die from COVID-19 than the vaccinated Unvaccinated Texans were 20 times more likely to die from COVID-19 and 13 times more likely to get infected with the virus from Sept. 4 to Oct. 1, according to a study released this week by the Texas Health Department. The difference in health outcomes varied among age groups, as unvaccinated people in their 40s were 55 times more likely to die from COVID-19, while unvaccinated people ages 75 and older were 12 times more likely to die. Dr. Jennifer Shuford, Texas's chief state epidemiologist, said that the study "quantifies what we’ve known for months." https://www.foxnews.com/health/texas-study-unvaccinated-people-20-times-more-likely-to-die-from-coronavirus-than-vaccinated-people And just in case you don't believe those leftists from Fox News, here's a direct link to the report itself. https://www.dshs.texas.gov/immunize/covid19/data/Cases-and-Deaths-by-Vaccination-Status-11082021.pdf Link to comment Share on other sites More sharing options...
Bkk Brian Posted November 11, 2021 Share Posted November 11, 2021 COVID antiviral pills: what scientists still want to know Drugs like molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world. https://www.nature.com/articles/d41586-021-03074-5 Link to comment Share on other sites More sharing options...
placeholder Posted November 11, 2021 Author Share Posted November 11, 2021 4 minutes ago, Bkk Brian said: COVID antiviral pills: what scientists still want to know Drugs like molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world. https://www.nature.com/articles/d41586-021-03074-5 Of course, one big problem with this is that treatment has to begin early in the course of the disease. Unfortunately, there seem to be lots of people ideologically committed to the belief that there is no such thing as covid-19 or that it results in no life endangering consequences. 1 Link to comment Share on other sites More sharing options...
Danderman123 Posted November 11, 2021 Share Posted November 11, 2021 13 hours ago, Atlantis said: “ Two former Ventavia employees spoke to The BMJ anonymously for fear of reprisal and loss of job prospects in the tightly knit research community. Both confirmed broad aspects of Jackson’s complaint. One said that she had worked on over four dozen clinical trials in her career, including many large trials, but had never experienced such a “helter skelter” work environment as with Ventavia on Pfizer’s trial. “I’ve never had to do what they were asking me to do, ever,” she told The BMJ. “It just seemed like something a little different from normal—the things that were allowed and expected.” She added that during her time at Ventavia the company expected a federal audit but that this never came.” @JustAnotherHun Thank you for bringing to attention actual and relevant faults related to Pfizer from the recent past. You would think that everyone would find your link informative in adjusting their confidence in the company’s claims, if even just a little. But no, topic gets immediately turned to the tiresome go-to refrain along the lines of “But don’t you know how well the vaccines work?!” Fortunately, Covid vaccines are tested beyond clinical trials conducted by the manufacturer. Link to comment Share on other sites More sharing options...
placeholder Posted November 11, 2021 Author Share Posted November 11, 2021 9 minutes ago, Danderman123 said: Fortunately, Covid vaccines are tested beyond clinical trials conducted by the manufacturer. Anyway, the trial was one of many trials conducted not by Pfizer but by various subcontractors. Link to comment Share on other sites More sharing options...
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