Popular Post gargamon Posted July 9, 2023 Popular Post Share Posted July 9, 2023 All this concern about getting addicted to cannabis, there's hope on the horizon... ------- BORDEAUX, France — Could AEF0117, a drug that has a novel mechanism of action in the brain, be the drug to fight cannabis addiction? Results from a phase 2a clinical trial that examined the efficacy of AEF0117 in patients with cannabis use disorder have created quite a stir. The study was published in Nature Medicine. Not only did AEF0117 weaken the effects of cannabis, but it also decreased a person's desire to use it, all without causing withdrawal symptoms. These findings have generated a significant buzz in the scientific and medical community. "In the past, 8% of cannabis users would develop an addiction — today, this figure is 15%. Addiction to cannabis has become the main reason for seeking treatment at specialist drug clinics," said Pier Vincenzo Piazza, MD, PhD, psychiatrist, neurobiologist, and general director of Aelis Farma, the biopharmaceutical company that developed AEF0117. This rise in cases can be explained by the increase in THC content in cannabis over the years. THC content increased from 5% in the 1970s to 30% today. Although cannabis is still less addictive than tobacco (33% of users become addicted), cocaine, heroin, or alcohol (25% of users become addicted), the number of cannabis users is increasing. Currently, 14.2 million in the United States and more than half a million in France use cannabis. https://www.medscape.com/viewarticle/993613 1 2 7 Link to comment Share on other sites More sharing options...
Popular Post save the frogs Posted July 9, 2023 Popular Post Share Posted July 9, 2023 I thought it wasnt even established unanimously on this forum that there is even such a thing as cannabis addiction. It's not clear what addiction means. And number of cannabis users increasing doesn't mean addiction is increasing. 2 3 2 Link to comment Share on other sites More sharing options...
Popular Post nglodnig Posted July 9, 2023 Popular Post Share Posted July 9, 2023 I've smoked weed every day, all day for the last fifty years and I'm STILL not addicted. 4 3 10 Link to comment Share on other sites More sharing options...
save the frogs Posted July 9, 2023 Share Posted July 9, 2023 1 hour ago, nglodnig said: I've smoked weed every day, all day for the last fifty years and I'm STILL not addicted. researchers should study people like you Link to comment Share on other sites More sharing options...
Popular Post pomchop Posted July 9, 2023 Popular Post Share Posted July 9, 2023 You want additiction? Smoke couple of packs of cigs for few decades and see how easy it is to quit? I should know as i quit at least a few dozen times but always went back...finally finally got off them for good about 15 years ago.....i can't even imagine what it would be like to be addicted to worse.... Weed? off and on all my adult life but not one time did i ever wake up in middle of the night when a blizzard was raging, get dressed, drive through blizzard til i found a place to get cigs and feed the addiction. Every one in a while i might thing gee maybe i will smoke a joint but sure would never ever go to the lengths that nicotine took me. 7 4 Link to comment Share on other sites More sharing options...
Popular Post Trippy Posted July 10, 2023 Popular Post Share Posted July 10, 2023 Cannabis addiction is a myth. 5 1 3 2 3 Link to comment Share on other sites More sharing options...
Popular Post bamnutsak Posted July 10, 2023 Popular Post Share Posted July 10, 2023 There seems to be a trend to first define a diagnosis, and that has coalesced around Cannabis Use Disorder (CUD). https://www.cdc.gov/marijuana/health-effects/addiction.html The following are signs of marijuana use disorder: Using more marijuana than intended Trying but failing to quit using marijuana Spending a lot of time using marijuana Craving marijuana Using marijuana even though it causes problems at home, school, or work Continuing to use marijuana despite social or relationship problems. Giving up important activities with friends and family in favor of using marijuana. Using marijuana in high-risk situations, such as while driving a car. Continuing to use marijuana despite physical or psychological problems. Needing to use more marijuana to get the same high. Experiencing withdrawal symptoms when stopping marijuana use. Then for people who suffer from CUD and seek treatment, mostly from private clinics, there might be medications which can be used. Seems quite preliminary, both the "disease" and the "treatment"? 3 Link to comment Share on other sites More sharing options...
Popular Post Trippy Posted July 10, 2023 Popular Post Share Posted July 10, 2023 20 minutes ago, bamnutsak said: There seems to be a trend to first define a diagnosis, and that has coalesced around Cannabis Use Disorder (CUD). https://www.cdc.gov/marijuana/health-effects/addiction.html The following are signs of marijuana use disorder: Using more marijuana than intended Trying but failing to quit using marijuana Spending a lot of time using marijuana Craving marijuana Using marijuana even though it causes problems at home, school, or work Continuing to use marijuana despite social or relationship problems. Giving up important activities with friends and family in favor of using marijuana. Using marijuana in high-risk situations, such as while driving a car. Continuing to use marijuana despite physical or psychological problems. Needing to use more marijuana to get the same high. Experiencing withdrawal symptoms when stopping marijuana use. Then for people who suffer from CUD and seek treatment, mostly from private clinics, there might be medications which can be used. Seems quite preliminary, both the "disease" and the "treatment"? What are the withdrawal symptoms exactly, for this mythical addiction? 1 1 4 Link to comment Share on other sites More sharing options...
Popular Post bamnutsak Posted July 10, 2023 Popular Post Share Posted July 10, 2023 1 hour ago, Trippy said: What are the withdrawal symptoms exactly, for this mythical addiction? I don't know. In my opinion, Cannabis is not physically addictive. I also do not think it is psychologically addictive. I was just summarizing what the anti-cannabis activists here trot out re: "addiction". They'll probably search for and link this article... The most common features of cannabis withdrawal are anxiety, irritability, anger or aggression, disturbed sleep/dreaming, depressed mood and loss of appetite. Less common physical symptoms include chills, headaches, physical tension, sweating and stomach pain. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110555/ 2 1 2 Link to comment Share on other sites More sharing options...
Popular Post Plern Posted July 10, 2023 Popular Post Share Posted July 10, 2023 I knew a guy who was addicted. He spent all his money on weed. When he scored a big bag he'd sick out from work and smoke the whole thing. Didn't do other drugs. 1 3 Link to comment Share on other sites More sharing options...
Tazmo Posted July 11, 2023 Share Posted July 11, 2023 Addiction is a disease and you won’t recognize it unless you worked in the field or had someone close to you who suffered or died! Use, abuse and misuse of substances including alcohol is as old as the hills. Many people indulge without any harm. It doesn’t mean to say that another person can do the same without harmful effects. I have known people who smoked all their life and never had lung cancer or drank alcohol all their life but never had cirrhosis. Sadly they are in a minority. Several factors contribute to becoming addicted to not only alcohol and substances but internet ; sex; love ; food . The addictive behavior takes over and controls your life, you become a ‘Slave’ to it! Put that in your pipe and smoke it, you doubting Thomases! lol Link to comment Share on other sites More sharing options...
Popular Post JBChiangRai Posted July 12, 2023 Popular Post Share Posted July 12, 2023 Most users live in their little bubble of normality, i.e. I'm not addicted so there is no addiction, I'm not violent so there is no violence. Some of us in the judiciary or medical field see what happens when it all goes wrong, and I can tell you that your bubble of normality is well and truly burst for us. 5 Link to comment Share on other sites More sharing options...
Popular Post ThaiFelix Posted July 12, 2023 Popular Post Share Posted July 12, 2023 On 7/10/2023 at 2:13 AM, nglodnig said: I've smoked weed every day, all day for the last fifty years and I'm STILL not addicted. Youre not trying hard enough! 3 Link to comment Share on other sites More sharing options...
ThaiFelix Posted July 12, 2023 Share Posted July 12, 2023 56 minutes ago, JBChiangRai said: Most users live in their little bubble of normality, i.e. I'm not addicted so there is no addiction, I'm not violent so there is no violence. Some of us in the judiciary or medical field see what happens when it all goes wrong, and I can tell you that your bubble of normality is well and truly burst for us. I think you explained it so eloquently at the bottom of your post: "All pigs fed & ready to fly." 2 Link to comment Share on other sites More sharing options...
ThaiFelix Posted July 12, 2023 Share Posted July 12, 2023 On 7/10/2023 at 5:10 AM, pomchop said: Weed? off and on all my adult life but not one time did i ever wake up in middle of the night when a blizzard was raging, get dressed, drive through blizzard til i found a place to get cigs and feed the addiction. Every one in a while i might thing gee maybe i will smoke a joint but sure would never ever go to the lengths that nicotine took me. Know exactly what you mean, been there, done that! I was the car in front lol! Link to comment Share on other sites More sharing options...
Kwaibill Posted July 12, 2023 Share Posted July 12, 2023 Just my observational opinion, but based on my observations of many friends and some relatives this “addiction” is primarily psychological. That said I do know of two tragic instances where it could honestly have been a gateway to heroin use. Again, a “decision” to try something “more”, but the more is defo addicting. 1 Link to comment Share on other sites More sharing options...
Popular Post ignore it Posted July 12, 2023 Popular Post Share Posted July 12, 2023 False premise. Just another Pharma study to create a need for their cure. (For a non problem.) Daily use required. Anybody need more Covid booster shots? 2 1 Link to comment Share on other sites More sharing options...
novacova Posted July 12, 2023 Share Posted July 12, 2023 If one is not addicted then there is no need for dependency of it for anything, won’t need it to cope, relax no urge for it, same with alcohol. There are many levels of dependency and addiction. My addiction is coffee and a clear head. 1 Link to comment Share on other sites More sharing options...
novacova Posted July 12, 2023 Share Posted July 12, 2023 On 7/10/2023 at 2:13 AM, nglodnig said: I've smoked weed every day, all day for the last fifty years and I'm STILL not addicted. …is why they call it dope 2 2 Link to comment Share on other sites More sharing options...
bradiston Posted July 12, 2023 Share Posted July 12, 2023 2 hours ago, Tazmo said: Addiction is a disease and you won’t recognize it unless you worked in the field or had someone close to you who suffered or died! Use, abuse and misuse of substances including alcohol is as old as the hills. Many people indulge without any harm. It doesn’t mean to say that another person can do the same without harmful effects. I have known people who smoked all their life and never had lung cancer or drank alcohol all their life but never had cirrhosis. Sadly they are in a minority. Several factors contribute to becoming addicted to not only alcohol and substances but internet ; sex; love ; food . The addictive behavior takes over and controls your life, you become a ‘Slave’ to it! Put that in your pipe and smoke it, you doubting Thomases! lol I've never really "got" the classification of addiction as a disease. I was addicted to nicotine, still am to some extent, but I quit. Used to drink but quit. Switched to low carb diet - you may laugh, but giving up sugar, bread, rice, potatoes, pasta etc is not easy after 70 years. To me it's simply STOP. Now how many other "diseases" can I cure like that? And regarding weed addiction. At university, the worst that could be described as an effect of smoking it, which we middle class white undergraduates did daily for months at a time, was the reluctance to get off the floor and go to lectures and seminars. No psychosis, no CUD, MAD, SUD nor any other depiction of addiction. Really, cannabis abuse, if it exists, is surely most likely to be caused by poverty, deprivation, and social situation, not the supposedly addictive properties of THC. Compared to crack/opioids synthetic or otherwise.... Well, I don't think there IS a comparison. It's just guilt by association. 1 1 Link to comment Share on other sites More sharing options...
Tazmo Posted July 12, 2023 Share Posted July 12, 2023 From your experience and the way you managed has worked well for you and I have no doubt that you worked hard to achieve the results you got. But by addiction I am referring to the over indulgence/ excessive use to a point where the individual is unable to function or recognize there is a problem until he/ she hits rock bottom. You really need to see it to understand or believe. I am not going to try to convince or argue with you. Some are able to deal with it while others struggle big time. 1 Link to comment Share on other sites More sharing options...
Popular Post Chongalulu Posted July 12, 2023 Popular Post Share Posted July 12, 2023 9 hours ago, JBChiangRai said: Some of us in the judiciary or medical field see what happens when it all goes wrong, and I can tell you that your bubble of normality is well and truly burst for us. By definition,in that field you're ONLY going to come across those where it has gone wrong. You'll be completely oblivious to the orders of magnitude more instances where there aren't harmful effects. Therein lies the problem with slanted anecdotal evidence. 2 1 2 Link to comment Share on other sites More sharing options...
MrMuddle Posted July 12, 2023 Share Posted July 12, 2023 On 7/10/2023 at 10:43 AM, Trippy said: Cannabis addiction is a myth. In these woke times, it may identify as a mythter.... 1 Link to comment Share on other sites More sharing options...
Felton Jarvis Posted July 12, 2023 Share Posted July 12, 2023 Cannabis is not addictive. Why would you need such a drug? 1 1 Link to comment Share on other sites More sharing options...
Popular Post Troy Tempest Posted July 13, 2023 Popular Post Share Posted July 13, 2023 (edited) Is a Drug to Treat Cannabis Addiction Finally Within Reach? Yes...It is called Cannabis! Every time I smoke Weed it is a TREAT! Edited July 13, 2023 by Troy Tempest 4 Link to comment Share on other sites More sharing options...
Popular Post Wuvu2 Posted July 13, 2023 Popular Post Share Posted July 13, 2023 This is a trick question right? I can confirm that daily doses of cannabis prevent Cannabis Addiction altogether ???? 2 1 Link to comment Share on other sites More sharing options...
nglodnig Posted July 14, 2023 Share Posted July 14, 2023 (edited) Actually coming up (true this) it IS fifty years since I first smoked da demon weed. Went through a period in my "yoof" where I smoked it frequently (for a while, yes every day all day) then got on with my life got married and had children, spliffs became more and more infrequent - sometimes years between tokes. NOW with the easy availabilty - every couple of days I'll have a mild spliff. Bored with it - the buzz is OK but not something I want to do all the time. There are addictive personalities that will get addicted to ANYTHING - it's not the fault of the chemical, it is with the person. Edited July 14, 2023 by nglodnig 1 Link to comment Share on other sites More sharing options...
drmal Posted July 19, 2023 Share Posted July 19, 2023 (edited) Funny to read all those who smoke "weed" everyday or every other day and boasting that they are not addicted. There's no reason to start smoking "weed" at all. All the so-called treatment from cannabis is actually the "myth". People just want to feel good by it. If you can't stop smoking cannabis forever, you ARE addicted. Edited July 19, 2023 by drmal 2 Link to comment Share on other sites More sharing options...
JBChiangRai Posted July 19, 2023 Share Posted July 19, 2023 18 minutes ago, drmal said: Funny to read all those who smoke "weed" everyday or every other day and boasting that they are not addicted. There's no reason to start smoking "weed" at all. All the so-called treatment from cannabis is actually the "myth". People just want to feel good by it. If you can't stop smoking cannabis forever, you ARE addicted. Yes, that was my take too. Link to comment Share on other sites More sharing options...
connda Posted July 20, 2023 Share Posted July 20, 2023 Cannabis is not addictive. 1 Link to comment Share on other sites More sharing options...
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