webfact Posted October 24, 2018 Share Posted October 24, 2018 Cancer research breakthrough By Pratch Rujivanarom The Nation Chula team says phase one yields success in bid to make cheaper biologic treatments but major funding boost needed CHULALONGKORN University’s research team has reached the first milestone in developing an affordable biologic drug but needs Bt1.33 billion in funding to pursue the remaining phases of the study. Chulalongkorn Cancer Immunotherapy Excellence Centre announced at a press conference yesterday that its team had made progress in the research to develop immunotherapy treatment for cancer. The team said they had successfully extracted the prototype antibody from mice, and they should be able to develop cheaper domestically produced immunotherapy cancer drugs within eight years. Lead researcher Dr Trairak Pisitkun said the prototype developed from a mice antibody has proved to be as effective as imported biological drugs, and the team was inching closer to achieving further progress in the second phase. “We are making good progress considering we began the research programme only in October last year,” he said. “However, we still have a long way to go before we can start producing biologic drugs at an affordable price. Immunotherapy currently costs up to Bt300,000 per dose in Thailand,” he said. Trairat explained that immunotherapy in some cases could cost as much as Bt8 million, which is far too expensive for many Thais. “This project would help Thailand produce its own biologic drugs, which could cost just Bt20,000 per dose, and would overwhelmingly cut down reliance on imported drugs,” Trairak said. “Moreover, it will promote the development of Thailand’s biologic drugs industry, which will benefit the economy.” Dr Nattiya Hirankarn, chief of the Chulolongkorn Cancer Immunotherapy Excellence Centre, said the centre was currently researching three immunotherapy treatment options – therapeutic antibody, cellular immunotherapy and personalised cancer vaccine. The study on therapeutic antibody or biologic drug for cancer had made the most progress, Nattiya said. “Biologic drugs help strengthen a cancer patient’s immune system so it can efficiently combat cancer cells. The medicine unlocks the protection system of cancer cells and allows white blood cells to eliminate them without harming other parts of the body,” Nattiya explained. It has been scientifically proved that biologic cancer immunotherapy can treat 15 types of cancer, including skin, lung, kidney, cervical and colorectal cancer without causing severe side effects. However, Chulalongkorn University’s Faculty of Medicine dean Dr Suttipong Wacharasindhu said research of this scale requires large sums of money, and even though the university has acquired a government budget of Bt160 million, it was far from enough to cover the entire project. Hence, the Cancer Immunotherapy Fund is trying to raise donations to help subsidise the programme. “As of yesterday, we have already received Bt73 million in donations. We are very grateful for the overwhelming response in a very short time,” he said. “However, our work is only in the initial phase, so we would like to seek continuous partnership and contributions for the path ahead.” Source: http://www.nationmultimedia.com/detail/national/30357112 -- © Copyright The Nation 2018-10-25 Link to comment Share on other sites More sharing options...
Thian Posted October 24, 2018 Share Posted October 24, 2018 Why not do this for whole Asia? I bet the Malaysians or Indo's also want this drug if it's really good. Link to comment Share on other sites More sharing options...
Darcula Posted October 24, 2018 Share Posted October 24, 2018 1 hour ago, webfact said: but major funding boost needed I've got the solution to world hunger. Major funding needed. Link to comment Share on other sites More sharing options...
Aussie999 Posted October 24, 2018 Share Posted October 24, 2018 "Cancer Research Breahthrough" what bloody "breakthrough, from what I read they are only trying to produce a know product locally, or did I miss something.... wait, it's really about funds.... ah the baht. Link to comment Share on other sites More sharing options...
jerojero Posted October 25, 2018 Share Posted October 25, 2018 Just add it to the Ebola cure announced couple years ago. Link to comment Share on other sites More sharing options...
mikebell Posted October 25, 2018 Share Posted October 25, 2018 Now there's just malaria and rabies left for the Thais to crack. There's much research going on in the latter field; the University is leaving rabid dogs outside a number of 7-11s. Link to comment Share on other sites More sharing options...
Borzandy Posted October 25, 2018 Share Posted October 25, 2018 4 hours ago, webfact said: to develop cheaper domestically produced immunotherapy cancer drugs within eight years. eight, nine, ten, ......... Link to comment Share on other sites More sharing options...
Kieran00001 Posted October 25, 2018 Share Posted October 25, 2018 1 hour ago, Aussie999 said: "Cancer Research Breahthrough" what bloody "breakthrough, from what I read they are only trying to produce a know product locally, or did I miss something.... wait, it's really about funds.... ah the baht. You missed something, its about being able to produce the drug cheaper, ah the baht, your baht. Link to comment Share on other sites More sharing options...
Thian Posted October 25, 2018 Share Posted October 25, 2018 46 minutes ago, mikebell said: Now there's just malaria and rabies left for the Thais to crack. There's much research going on in the latter field; the University is leaving rabid dogs outside a number of 7-11s. For rabies they might get the funds soon from Holland where they're collecting money to stop rabies in poor countries...they show many very sad ad's on tv daily about soidogs who look like it's their last day alive and for sure the Dutch will donate because they can't stand the sight of dogs being treated that way.... Link to comment Share on other sites More sharing options...
Esso49 Posted October 25, 2018 Share Posted October 25, 2018 1 hour ago, jerojero said: Just add it to the Ebola cure announced couple years ago. They also claimed an HIV cure years before that place other dubious claims in other fields of research Just smokescreens to attempt to convince the populace that Thailand's University research is on the up when by world standards it is in freefall as are the rest of their educational standards. That's what the Elite and Junta want to control the masses in their 17th century approach to ensure personal enrichment. These lot make the Nigerians look like petty thieves. Link to comment Share on other sites More sharing options...
varun Posted October 25, 2018 Share Posted October 25, 2018 Thai logic at it's best - large scale production BEFORE clinical trials? What if the trial fails? It's the rice scheme all over again. Link to comment Share on other sites More sharing options...
Lupatria Posted October 25, 2018 Share Posted October 25, 2018 They must have found out how much Dr. Quack is forking in with his "free" herbal cancer cure on donations. Link to comment Share on other sites More sharing options...
robblok Posted October 25, 2018 Share Posted October 25, 2018 15 minutes ago, varun said: Thai logic at it's best - large scale production BEFORE clinical trials? What if the trial fails? It's the rice scheme all over again. I disagree.. you must indeed go to large scale production to see if its viable and what kind of problems you run into. This is of course not as large a production as later on for sale. At first there is almost no production you must scale that up for all the other tests that need to be run. I am quite sure other companies do the same. After a prototype they always start a larger scale production to see if its possible.. then after tests even larger scale. Link to comment Share on other sites More sharing options...
Kieran00001 Posted October 25, 2018 Share Posted October 25, 2018 16 minutes ago, varun said: Thai logic at it's best - large scale production BEFORE clinical trials? What if the trial fails? It's the rice scheme all over again. It would be kinda difficult to run a large scale trial without having produced the drug on a large scale, their steps are standard. Link to comment Share on other sites More sharing options...
arithai12 Posted October 25, 2018 Share Posted October 25, 2018 4 hours ago, Darcula said: I've got the solution to world hunger. Major funding needed. Making less children doesn't require much funding. But you got the drift right. Link to comment Share on other sites More sharing options...
Phuketshrew Posted October 25, 2018 Share Posted October 25, 2018 4 hours ago, Darcula said: I've got the solution to world hunger. Major funding needed. I'm working on a cure for stupidity, but I think I'll need more than 1.4 billion to crack it ???? Link to comment Share on other sites More sharing options...
varun Posted October 25, 2018 Share Posted October 25, 2018 43 minutes ago, robblok said: I disagree.. you must indeed go to large scale production to see if its viable and what kind of problems you run into. This is of course not as large a production as later on for sale. At first there is almost no production you must scale that up for all the other tests that need to be run. I am quite sure other companies do the same. After a prototype they always start a larger scale production to see if its possible.. then after tests even larger scale. Hmm yes, I'm not familiar with how Big Pharma works. I suppose in this context they mean large-scale production to support (large-scale) clinical trials, not mass-production for commercial distribution. The timelines are way too optimistic though - they're probably looking at 10 years minimum. Link to comment Share on other sites More sharing options...
Redline Posted October 25, 2018 Share Posted October 25, 2018 Let’s just say I’m reluctantly optimistic. That lab looks like it’s from the 1980s Link to comment Share on other sites More sharing options...
robblok Posted October 25, 2018 Share Posted October 25, 2018 6 minutes ago, varun said: Hmm yes, I'm not familiar with how Big Pharma works. I suppose in this context they mean large-scale production to support (large-scale) clinical trials, not mass-production for commercial distribution. The timelines are way too optimistic though - they're probably looking at 10 years minimum. Quite probably way to optimistic, can't really say anything about that. But it always takes real long to put something on the market. Link to comment Share on other sites More sharing options...
inactiveposter Posted October 25, 2018 Share Posted October 25, 2018 This sounds very similar to a drug tested in 2000 - Bexxar for the treatment of Non-Hodgkins Lymphoma. It was a radioactive mono-clonal drug using mouse antibodies. It was a one dose test with the trial and follow-up lasting 10 years. The end result - not a breakthrough.Sent from my iPad using Thaivisa Connect Link to comment Share on other sites More sharing options...
Orton Rd Posted October 25, 2018 Share Posted October 25, 2018 Although they claim top 300 ranked in the world and top 50 in Asia I tend to think the Times rating more like it 800 at best and 164 in Asia https://www.timeshighereducation.com/world-university-rankings/chulalongkorn-university Link to comment Share on other sites More sharing options...
madmitch Posted October 25, 2018 Share Posted October 25, 2018 1 hour ago, Thian said: For rabies they might get the funds soon from Holland where they're collecting money to stop rabies in poor countries...they show many very sad ad's on tv daily about soidogs who look like it's their last day alive and for sure the Dutch will donate because they can't stand the sight of dogs being treated that way.... Interesting. When I was last in Amsterdam you had to walk looking down the whole time to avoid the dog turds. I'd like to think this isn't the case any more - it was several years ago. Anyone know? Sorry, this is very off-topic! Link to comment Share on other sites More sharing options...
atyclb Posted October 25, 2018 Share Posted October 25, 2018 1 hour ago, varun said: Thai logic at it's best - large scale production BEFORE clinical trials? What if the trial fails? It's the rice scheme all over again. likely they are just making a generic version of an already tested drug. many cancer drugs and viral drugs are extremely expensive and are not covered by national healthcare so if you dont have cash "cest la vie" the hepatitis treatment "harvoni" runs 84K usd in america. the same treatment in india about 900usd Link to comment Share on other sites More sharing options...
Thian Posted October 25, 2018 Share Posted October 25, 2018 8 minutes ago, madmitch said: Interesting. When I was last in Amsterdam you had to walk looking down the whole time to avoid the dog turds. I'd like to think this isn't the case any more - it was several years ago. Anyone know? Sorry, this is very off-topic! Well there aren't many dogs in Amsterdam these days and it's illegal to let them shit on the streets...they even bring dogs inside the airport but for sure they're all vaccinated and registered, if you get bitten you can claim the owner and will always win.. Link to comment Share on other sites More sharing options...
ChrisY1 Posted October 25, 2018 Share Posted October 25, 2018 The laboratory looks really modern....anything could be discovered in there! Link to comment Share on other sites More sharing options...
Fex Bluse Posted October 25, 2018 Share Posted October 25, 2018 18 minutes ago, Orton Rd said: Although they claim top 300 ranked in the world and top 50 in Asia I tend to think the Times rating more like it 800 at best and 164 in Asia https://www.timeshighereducation.com/world-university-rankings/chulalongkorn-university. I would agree. Chula wouldn't compete with community colleges in the US or trade schools in Europe. Well, other than in the cuteness of the little ladies in their uniforms 8 minutes ago, atyclb said: likely they are just making a generic version of an already tested drug. many cancer drugs and viral drugs are extremely expensive and are not covered by national healthcare so if you dont have cash "cest la vie" the hepatitis treatment "harvoni" runs 84K usd in america. the same treatment in india about 900usd The Indians are clever and have behemoths like Ranbaxy making legit off-label drugs. They were willing to learn from others. The Thais? Doubtful they have the expertise or necessary character do mass produce precision medicine. And, they are incapable of learning from others. Link to comment Share on other sites More sharing options...
atyclb Posted October 25, 2018 Share Posted October 25, 2018 5 minutes ago, Fex Bluse said: I would agree. Chula wouldn't compete with community colleges in the US or trade schools in Europe. Well, other than in the cuteness of the little ladies in their uniforms The Indians are clever and have behemoths like Ranbaxy making legit off-label drugs. They were willing to learn from others. The Thais? Doubtful they have the expertise or necessary character do mass produce precision medicine. And, they are incapable of learning from others. even though there are some thai's capable and some that have actually studied abroad, when they return they face their system that is often "self defeating" Link to comment Share on other sites More sharing options...
Srikcir Posted October 25, 2018 Share Posted October 25, 2018 2 hours ago, Kieran00001 said: You missed something, its about being able to produce the drug cheaper, ah the baht, your baht. Yes, it's an alleged economic breakthrough, not a medical breakthrough. Link to comment Share on other sites More sharing options...
poohy Posted October 25, 2018 Share Posted October 25, 2018 Thai university research that gave us cures for Ebola and HIV Forgive me if i dont get too excited about this! Link to comment Share on other sites More sharing options...
Kieran00001 Posted October 25, 2018 Share Posted October 25, 2018 38 minutes ago, Orton Rd said: Although they claim top 300 ranked in the world and top 50 in Asia I tend to think the Times rating more like it 800 at best and 164 in Asia https://www.timeshighereducation.com/world-university-rankings/chulalongkorn-university 517 by RankingWeb, they are the biggest, 28,000 uni's ranked. http://www.webometrics.info/en/Asia/Thailand Link to comment Share on other sites More sharing options...
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