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29 minutes ago, dinsdale said:

High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept clinical trial

https://pmc.ncbi.nlm.nih.gov/articles/PMC8734085/

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

https://www.ijidonline.com/article/S1201-9712(20)32506-6/fulltext

 

Gag! You did not even read them! 😀

 

Here's the conclusion of the first article. I did not waste my time further by reading the second one (from Bangkadesh).

 

'In conclusion, we did not demonstrate a significant reduction in viral load between ivermectin and placebo, although a trend for the highest dose is apparent. Whether this drug might have clinical efficacy at lower doses remains debated. We believe that our findings further support the WHO recommendation suggesting that it is currently advisable to refrain from administrating ivermectin for the treatment of COVID-19 outside of clinical trials."  😀

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36 minutes ago, candide said:

Gag! You did not even read them! 😀

 

Here's the conclusion of the first article. I did not waste my time further by reading the second one (from Bangkadesh).

 

'In conclusion, we did not demonstrate a significant reduction in viral load between ivermectin and placebo, although a trend for the highest dose is apparent. Whether this drug might have clinical efficacy at lower doses remains debated. We believe that our findings further support the WHO recommendation suggesting that it is currently advisable to refrain from administrating ivermectin for the treatment of COVID-19 outside of clinical trials."  😀

although a trend for the highest dose is apparent.

 

"I did not waste my time further by reading the second one (from Bangkadesh)."

 

Well there you go. Shows how you come to conclusions. Had you done so you would have seen this...

 

"Although the study sample was too small (n = 72) to draw any solid conclusions, the results provide evidence of the potential benefit of early intervention with the drug ivermectin for the treatment of adult patients diagnosed with mild COVID-19. First, early intervention promoted faster viral clearance during disease onset, which might have prevented significant immune system involvement and hastened the recovery. Secondly, early intervention reduced the viral load faster, thus may help block disease transmission in the general population. A larger randomized controlled clinical trial of ivermectin treatment appears to be warranted to validate these important findings."

 

Of course big pharma came in cited studies that used Ivermectin too late into the infection where it's ineffective and the rest is history. Even mentioning Ivermectin got people demonized, demonetized (YT) and censored on social media platforms. No money in Ivermectin. No billions of dollars to be made.

Edited by dinsdale
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2 hours ago, dinsdale said:

although a trend for the highest dose is apparent.

 

"I did not waste my time further by reading the second one (from Bangkadesh)."

 

Well there you go. Shows how you come to conclusions. Had you done so you would have seen this...

 

"Although the study sample was too small (n = 72) to draw any solid conclusions, the results provide evidence of the potential benefit of early intervention with the drug ivermectin for the treatment of adult patients diagnosed with mild COVID-19. First, early intervention promoted faster viral clearance during disease onset, which might have prevented significant immune system involvement and hastened the recovery. Secondly, early intervention reduced the viral load faster, thus may help block disease transmission in the general population. A larger randomized controlled clinical trial of ivermectin treatment appears to be warranted to validate these important findings."

 

Of course big pharma came in cited studies that used Ivermectin too late into the infection where it's ineffective and the rest is history. Even mentioning Ivermectin got people demonized, demonetized (YT) and censored on social media platforms. No money in Ivermectin. No billions of dollars to be made.

So you cited a study which concluded there was no significant effect compared to a placebo, and a single study from Bengladesh mentioning the sample was too small to draw solid conclusion.(study financed by Beximco Pharmaceutical, which BTW produces an Ivermectin generic called Ivera)

 

Then you evoke a conspiracy theory, as usual, to discredit a meta analysis of several studies screened by the authors. Oh, and you also claim these selected studies used Ivermectin too late, without having read these studies so you have no way to have known whether they used it late or not.

 

How to say....

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2 hours ago, candide said:

So you cited a study which concluded there was no significant effect compared to a placebo, and a single study from Bengladesh mentioning the sample was too small to draw solid conclusion.(study financed by Beximco Pharmaceutical, which BTW produces an Ivermectin generic called Ivera)

 

Then you evoke a conspiracy theory, as usual, to discredit a meta analysis of several studies screened by the authors. Oh, and you also claim these selected studies used Ivermectin too late, without having read these studies so you have no way to have known whether they used it late or not.

 

How to say....

:coffee1:

Edited by dinsdale
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5 hours ago, dinsdale said:

High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept clinical trial

https://pmc.ncbi.nlm.nih.gov/articles/PMC8734085/

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

https://www.ijidonline.com/article/S1201-9712(20)32506-6/fulltext

 

 

You have just demonstrated what happens when uneducated and ignorant people read a document, and do not understand what it states. The study actually  states that  Ivermectin is ineffective as a treatment and should not be used.

Your attention is drawn to the following key statements;The Abstract opening  sentences state;

High concentrations of ivermectin demonstrated antiviral activity against SARS-CoV-2 in vitro. The aim of this study was to assess the safety and efficacy of high-dose ivermectin in reducing viral load in individuals with early SARS-CoV-2 infection. 

 

INVITRO This means outside the  living organism, i.e. in a petri dish. It does not mean  in humans. The study was to determine if the dosing that resulted in the result observed was safe for use in humans. This was not a clinical trial of the efficacy of the drug in the treatment of a Covid infection.

 

Last line of abstract: High-dose ivermectin was safe but did not show efficacy to reduce viral load.

This means that ivermectin did not reduce the viral load in the patients.  

 

Cutting and pasting a reference taken out of context neither improves nor changes the  conclusions. Thank you for inadvertently supporting my position and providing a reason why your claim was  wrong.

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3 minutes ago, Patong2021 said:

 

You have just demonstrated what happens when uneducated and ignorant people read a document, and do not understand what it states. The study actually  states that  Ivermectin is ineffective as a treatment and should not be used.

Your attention is drawn to the following key statements;The Abstract opening  sentences state;

High concentrations of ivermectin demonstrated antiviral activity against SARS-CoV-2 in vitro. The aim of this study was to assess the safety and efficacy of high-dose ivermectin in reducing viral load in individuals with early SARS-CoV-2 infection. 

 

INVITRO This means outside the  living organism, i.e. in a petri dish. It does not mean  in humans. The study was to determine if the dosing that resulted in the result observed was safe for use in humans. This was not a clinical trial of the efficacy of the drug in the treatment of a Covid infection.

 

Last line of abstract: High-dose ivermectin was safe but did not show efficacy to reduce viral load.

This means that ivermectin did not reduce the viral load in the patients.  

 

Cutting and pasting a reference taken out of context neither improves nor changes the  conclusions. Thank you for inadvertently supporting my position and providing a reason why your claim was  wrong.

And your response to this is?

A 5-day course of ivermectin resulted in an earlier clearance of the virus compared to placebo (p = 0.005), thus indicating that early intervention with this agent may limit viral replication within the host. In the 5-day ivermectin group, there was a significant drop in CRP and LDH by day 7, which are indicators of disease severity. It is noteworthy that the viral nucleic acid Ct value (indicator of viral load) dropped significantly compared to the placebo group on day 7 and day 14. In the absence of co-morbidity, a 5-day course of ivermectin treatment showed faster SARS-CoV-2 virus clearance compared to the placebo arm (9 vs 13 days; p = 0.02).

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