Colonoscopy and polyps

[ericbj]

In case of interest to some, I just found this :
https://www.facebook.com/share/p/18wWTfWsNd/

 

[proton]

12 minutes ago, ericbj said:

In case of interest to some, I just found this :
https://www.facebook.com/share/p/18wWTfWsNd/

 

 

Speculation no evidence, heavy metals causing polyps? that's a new one

[ericbj]

32 minutes ago, proton said:

 

Speculation no evidence, heavy metals causing polyps? that's a new one

There may be no hard and fast evidence of direct causation of polyps by heavy metals.  But heavy metals can be associated with gut dysbiosis which can have many adverse effects upon the body.  Such as causing inflammation of the intestines.
(and incidentally gut dysbiosis has now been linked to mental problems, in addition to the problems caused by the presence of heavy metals in the brain itself)

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Distinct gut microbiomes in Thai
patients with colorectal polyps. (/
article/distinct-gut-microbiomes-
thai-patients-colorectal-polyps)
Distinct gut microbiomes in Thai patients with colorectal polyps.
World J Gastroenterol. 2024 Jul 21 ;30(27):3336-3355. PMID: 39086748
(http://www.ncbi.nlm.nih.gov/pubmed/39086748)
Thoranin Intarajak, Wandee Udomchaiprasertkul, Ahmad Nuruddin Khoiri,
Sawannee Sutheeworapong, Kanthida Kusonmano, Weerayuth Kittichotirat,
Chinae Thammarongtham, Supapon Cheevadhanarak
Thoranin Intarajak
BACKGROUND: Colorectal polyps that developthe conventional adenoma-
carcinoma sequence [, tubular adenoma (TA)] often progress to malignancy and
are closely associated with changes in the composition of the gut microbiome.
There is limited research concerning the microbial functions and gut
microbiomes associated with colorectal polyps that arise through the serrated
polyp pathway, such as hyperplastic polyps (HP). Exploration of microbiome
alterations associated with HP and TA would improve the understanding of
mechanisms by which specific microbes and their metabolic pathways contribute
to colorectal carcinogenesis.
AIM: To investigate gut microbiome signatures, microbial associations, and
microbial functions in HP and TA patients.
METHODS: Full-length 16S rRNA sequencing was used to characterize the gut
microbiome in stool samples from control participants without polyps [control
group (CT),= 40], patients with HP (= 52), and patients with TA (= 60).
Significant differences in gut microbiome composition and functional
mechanisms were identified between the CT group and patients with HP or TA.
Analytical techniques in this study included differential abundance analysis, co-
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Distinct gut microbiomes in Thai patients with colorectal polyps. https://greenmedinfo.com/article/distinct-gut-microbiomes-thai-patien...
1 of 5 1/28/2025, 10:05 PM
Analytical techniques in this study included differential abundance analysis, co-
occurrence network analysis, and differential pathway analysis.
RESULTS: Colorectal cancer (CRC)-associated bacteria, including(),, and, were
identified as characteristic microbial species in TA patients.associated with
dysbiosis and gastrointestinal diseases, was significantly differentially abundant
in the HP and TA groups. Functional pathway analysis revealed that HP patients
exhibited enrichment in the sulfur oxidation pathway exclusively, whereas TA
patients showed dominance in pathways related to secondary metabolite
biosynthesis (, mevalonate);was a major contributor. Co-occurrence network
and dynamic network analyses revealed co-occurrence of dysbiosis-associated
bacteria in HP patients, whereas TA patients exhibited co-occurrence of CRC-
associated bacteria. Furthermore, the co-occurrence of SCFA-producing bacteria
was lower in TA patients than HP patients.
CONCLUSION: This study revealed distinct gut microbiome signatures associated
with pathways of colorectal polyp development, providing insights concerning
the roles of microbial species, functional pathways, and microbial interactions in
colorectal carcinogenesis.