Another go with Monurol to kill my prostatitis...

[simon43]

I've had prostatitis for several years, down to E.Coli ESBL, and it not only plays havoc with my PSA numbers, it causes pain when peeing, a dreadful fishy smell, aches in my pelvic region etc. I'm sure it's not healthy in the long-term to have this bacteria...

 

I know that Carbapenems are the first line of treatment, but the cost of this expensive treatment is beyond my financial means, and BPH/prostatitis etc are excluded on my medical cover.

 

I did try a single dose of Monurol a few years ago, with no beneficial effect noticed.  This time, I'll try 3g/day, administered every other day for 3 days. See if that kills the ba stards!!

[Hawaiian]

4 hours ago, simon43 said:

I've had prostatitis for several years, down to E.Coli ESBL, and it not only plays havoc with my PSA numbers, it causes pain when peeing, a dreadful fishy smell, aches in my pelvic region etc. I'm sure it's not healthy in the long-term to have this bacteria...

 

I know that Carbapenems are the first line of treatment, but the cost of this expensive treatment is beyond my financial means, and BPH/prostatitis etc are excluded on my medical cover.

 

I did try a single dose of Monurol a few years ago, with no beneficial effect noticed.  This time, I'll try 3g/day, administered every other day for 3 days. See if that kills the ba stards!!

Have you tried Bactrim.  Worked for me when I had similar symptoms.

[simon43]

1 hour ago, Hawaiian said:

Have you tried Bactrim.  Worked for me when I had similar symptoms.

Thanks.  I'll try the Monurol and then if that's no good I can try Bactrim!

[Lacessit]

I suggest you prioritize your spending to afford the carbapenems.

 

You are right, definitely not good long term.

 

What's more important, your health or money?

[simon43]

11 minutes ago, Lacessit said:

I suggest you prioritize your spending to afford the carbapenems.

 

You are right, definitely not good long term.

 

What's more important, your health or money?

Well, I can afford this drug if pushed to it.  But there is no quarantee that the treatment will actually work.  I think a course of injections is about 15,000 baht, but I might be 15k out of pocket and still with the infection...

[Will B Good]

6 hours ago, simon43 said:

I've had prostatitis for several years, down to E.Coli ESBL, and it not only plays havoc with my PSA numbers, it causes pain when peeing, a dreadful fishy smell, aches in my pelvic region etc. I'm sure it's not healthy in the long-term to have this bacteria...

 

I know that Carbapenems are the first line of treatment, but the cost of this expensive treatment is beyond my financial means, and BPH/prostatitis etc are excluded on my medical cover.

 

I did try a single dose of Monurol a few years ago, with no beneficial effect noticed.  This time, I'll try 3g/day, administered every other day for 3 days. See if that kills the ba stards!!

 

In agony for weeks….took one dose of Monurol and I nearly cried at the relief…..fingers crossed for you….(and it tastes so nice..555)

[Lacessit]

8 minutes ago, simon43 said:

Well, I can afford this drug if pushed to it.  But there is no quarantee that the treatment will actually work.  I think a course of injections is about 15,000 baht, but I might be 15k out of pocket and still with the infection...

As they say, up to you.

[Lacessit]

5 minutes ago, Will B Good said:

 

In agony for weeks….took one dose of Monurol and I nearly cried at the relief…..fingers crossed for you….(and it tastes so nice..555)

Sadly, the adaptability of bacteria to pharmaceuticals means what works for one person does not necessarily work for another.

 

Good to see in your case, fingers crossed for the OP.

[Will B Good]

4 minutes ago, Lacessit said:

Sadly, the adaptability of bacteria to pharmaceuticals means what works for one person does not necessarily work for another.

 

Good to see in your case, fingers crossed for the OP.

 

I tell you it was ****ing amazing.

 

Even after all this time I’m still amazed/shocked at the impact….….and as you say fingers crossed for the OP.

[Sheryl]

2 hours ago, simon43 said:

Thanks.  I'll try the Monurol and then if that's no good I can try Bactrim!

If I recall correctly you had a culture & sensitivity which showed the organism is resistant to most antibiotics including sulfonamides. 

 

Treatment should be based on that not what helped other people whose pathogens likely differed. 

[mstevens]

I know it might sound like an "out there" idea, but have you considered trying an alternative medicine practitioner for this if your latest round of treatment doesn't work? You might find some of the natural anti-microbials that herbalists use like oregano oil, clove oil etc might work. A quick Google search shows that some of these are listed as effective against E coli.

 

I had a gastro issue that mainstream medicine couldn't fix and I eventually ended up with an alternative medical practitioner in Australia. It took 3 months treatment with a personalised liquid herb concoction to fix the problem which 3 years of doctor and hospital visits couldn't resolve.

 

You might also consider a Traditional Chinese Medicine practitioner, of which there are many in Bangkok. They use similar herbs with anti-microbial properties.

 

Best of luck with the current treatment protocol.

[Hawaiian]

6 hours ago, simon43 said:

Thanks.  I'll try the Monurol and then if that's no good I can try Bactrim!

After reading Sheryl's post I looked up E. coli, ESBL.  All recommendations said treatment is carbapenem.  Bactrim is inexpensive and regimen is around 5 days.  Up to you.  Good luck.

[Hawaiian]

49 minutes ago, Hawaiian said:

After reading Sheryl's post I looked up E. coli, ESBL.  All recommendations said treatment is carbapenem.  Bactrim is inexpensive and regimen is around 5 days.  Up to you.  Good luck.

My apologies.  I was prescribed DOXYCYCLINE HYCLATE and not BACTRIM.  They are not the same.

Listen to Sheryl.  She knows what she is talking about.

[simon43]

Sheryl has a good memory concerning sensitivity results.  The last test that I had at Life Care last June showed a PSA of 8.9 and sensitivity to Carbapenems, also Amoxicillin somewhat.

 

My concern about having a course of Carbapenem is what hospital/doctor in Pattaya can I trust to actually give me the correct course of treatment, and not throw in a whole load of unnecessary and expensive tests.  IE - I need a doctor who will get straight to the correct course of treatment.

 

 

[Hawaiian]

1 hour ago, simon43 said:

Sheryl has a good memory concerning sensitivity results.  The last test that I had at Life Care last June showed a PSA of 8.9 and sensitivity to Carbapenems, also Amoxicillin somewhat.

 

My concern about having a course of Carbapenem is what hospital/doctor in Pattaya can I trust to actually give me the correct course of treatment, and not throw in a whole load of unnecessary and expensive tests.  IE - I need a doctor who will get straight to the correct course of treatment.

 

 

Wish I could help, but I live in Hawaii.  In the past Sheryl has been pretty good at furnishing that kind of information.  Hopefully, she sees this.

I had a PSA reading much higher than that, but my UTI symptoms have gone away for now after taking the doxycycline hyclate.  Next visit with my urologist is a couple of months from now.

[scubascuba3]

2 hours ago, simon43 said:

Sheryl has a good memory concerning sensitivity results.  The last test that I had at Life Care last June showed a PSA of 8.9 and sensitivity to Carbapenems, also Amoxicillin somewhat.

 

My concern about having a course of Carbapenem is what hospital/doctor in Pattaya can I trust to actually give me the correct course of treatment, and not throw in a whole load of unnecessary and expensive tests.  IE - I need a doctor who will get straight to the correct course of treatment.

 

 

There's a good urologist at Queen Sirikit or Pattaya International, I'd go and see him, he did a minor op on me and a bladder op on a friend, good reports all round, plus not rip off pricing

[Lacessit]

3 hours ago, Hawaiian said:

Wish I could help, but I live in Hawaii.  In the past Sheryl has been pretty good at furnishing that kind of information.  Hopefully, she sees this.

I had a PSA reading much higher than that, but my UTI symptoms have gone away for now after taking the doxycycline hyclate.  Next visit with my urologist is a couple of months from now.

Doxycycline is effective against a number of urinary tract infections. Years ago, I had a virulent UTI, including pus. The first pill of the course of doxycycline stopped the infection in its tracks.

 

Co-incidentally, doxy is also prescribed as a malaria prophylactic. However, prolonged use may weaken the immune system.

[Will B Good]

3 hours ago, scubascuba3 said:

There's a good urologist at Queen Sirikit or Pattaya International, I'd go and see him, he did a minor op on me and a bladder op on a friend, good reports all round, plus not rip off pricing

 

 

Just happened to be reading this….legs crossed.

 

Samuel Pepys is famously known for undergoing a significant medical procedure in 1658: the removal of a bladder stone. This surgery, known as a lithotomy, was incredibly risky at the time due to the lack of anesthesia and high risk of infection. Pepys, aged 25, survived the operation and commemorated the anniversary of this event each year as his “stone day.”

[Hawaiian]

49 minutes ago, Lacessit said:

Doxycycline is effective against a number of urinary tract infections. Years ago, I had a virulent UTI, including pus. The first pill of the course of doxycycline stopped the infection in its tracks.

 

Co-incidentally, doxy is also prescribed as a malaria prophylactic. However, prolonged use may weaken the immune system.

 I phoned my PCP about my symptoms which included nausea. He faxed the pharmacy and told me to pick it up. Directions were 100mg caps twice a day for five days.  Being his patient for over 25 years we have an excellent relationship.  His diagnostic skills are tops. 

This is my first time for doxy.  I make sure I load up on probiotics after any antibiotic.  Various kimchi and Greek yogurt are a staple in our house. 

[Lacessit]

1 minute ago, Hawaiian said:

 I phoned my PCP about my symptoms which included nausea. He faxed the pharmacy and told me to pick it up. Directions were 100mg caps twice a day for five days.  Being his patient for over 25 years we have an excellent relationship.  His diagnostic skills are tops. 

This is my first time for doxy.  I make sure I load up on probiotics after any antibiotic.  Various kimchi and Greek yogurt are a staple in our house. 

AFAIK the acronym PCP is used for a mind-altering street drug, phencyclidine. Enlighten me, please.

 

Good luck with the course of doxy.

[Sheryl]

6 hours ago, simon43 said:

Sheryl has a good memory concerning sensitivity results.  The last test that I had at Life Care last June showed a PSA of 8.9 and sensitivity to Carbapenems, also Amoxicillin somewhat.

 

My concern about having a course of Carbapenem is what hospital/doctor in Pattaya can I trust to actually give me the correct course of treatment, and not throw in a whole load of unnecessary and expensive tests.  IE - I need a doctor who will get straight to the correct course of treatment.

 

 

Do not bother with anything other than the antibiotics listed as S.

 

Doctor might want to repeat the culture before yreating since report is old and may (should) repeat after treatment. That and maybe a PSA are all I would expect by way if tests and they are not codtly. It is the medication that will cost. 

 

Your main issue will be persuading them to let you come daily for infusion rather than bring admitted to hospital. 

 

[Sheryl]

2 hours ago, Lacessit said:

Doxycycline is effective against a number of urinary tract infections. Years ago, I had a virulent UTI, including pus. The first pill of the course of doxycycline stopped the infection in its tracks.

 

Co-incidentally, doxy is also prescribed as a malaria prophylactic. However, prolonged use may weaken the immune system.

The OP has had this infection many years and  long ago maxxed out on common antibiotics like doxy, bactrim etc. Even quinolones. 

 

He has multi-drug resistant infection responsive to only a small range of new antiobiotics that must be given intravenously. 

[Hawaiian]

2 minutes ago, Lacessit said:

AFAIK the acronym PCP is used for a mind-altering street drug, phencyclidine. Enlighten me, please.

 

Good luck with the course of doxy. 

Sorry, PCP stands for primary care physician;  they use to be referred to as the family doctor.  I have a urologist but I knew he was out of town.

I mentioned in a previous post that doxy worked wonderfully for me.  That was 6 months ago.

[bamnutsak]

22 hours ago, simon43 said:

I did try a single dose of Monurol a few years ago

 

My doctor prescribed Monurol. Three doses, every third day. So Mon, Thu and Sun. Each dosage is 3 grams.

Worked for me.

[Yagoda]

Bactrim and taladafil. Took a year. Check your teeth.

[Lacessit]

34 minutes ago, Sheryl said:

The OP has had this infection many yrars and  long ago maxxed out on common antibiotics like doxy, bactrim etc. Even quinolones. 

 

He has multi-drug redistant infection responsive to only a small range of new antiobiotics that must be given intravenously. 

I did read your previous posts on this thread, Sheryl. Not disputing for a nanosecond your recommendation, doxy was a by the way post.

[newbee2022]

22 hours ago, simon43 said:

I've had prostatitis for several years, down to E.Coli ESBL, and it not only plays havoc with my PSA numbers, it causes pain when peeing, a dreadful fishy smell, aches in my pelvic region etc. I'm sure it's not healthy in the long-term to have this bacteria...

 

I know that Carbapenems are the first line of treatment, but the cost of this expensive treatment is beyond my financial means, and BPH/prostatitis etc are excluded on my medical cover.

 

I did try a single dose of Monurol a few years ago, with no beneficial effect noticed.  This time, I'll try 3g/day, administered every other day for 3 days. See if that kills the ba stards!!

Of course nobody will give you here a proper diagnosis or treatment proposals. That's against all rules.

However, it's important to know where and how your proplem startet.

Only a qualified urologist can give you advise.

It's common sense that in about ten percent of cases, the cause is an infection of the prostate with bacteria (bacterial prostatitis). The bacteria enter the prostate either via the blood (hematogenous) or from neighboring organs such as the bladder or urethra (ascending), where they trigger the inflammatory reaction. The Escherichia coli bacterium (E. coli), which is found primarily in the human intestine, is the most common cause of prostate inflammation. Klebsiella, enterococci, or mycobacteria also cause prostatitis. Sexually transmitted bacterial pathogens such as chlamydia, trichomonads, or gonococci (in the case of gonorrhea) are also possible causes.

In chronic prostatitis, the bacteria in the prostate evade the defenses of the human immune system in a way that is not yet fully understood. This allows the germs to colonize the prostate permanently. Antibiotics also have relatively little effect on prostate tissue, which may encourage the bacteria to survive in the prostate.

So, please discuss your case with your doctor.

[xylophone]

6 minutes ago, Sheryl said:

The OP has had yjis infection many yrars and  long ago maxxed out on common antibiotics like doxy, bactrim etc. Even quinolones. 

 

He has multi-drug redistant infection responsive to only a small rangd of new antiobiotics that must be given intravenously. 

 

4 minutes ago, newbee2022 said:

In chronic prostatitis, the bacteria in the prostate evade the defenses of the human immune system in a way that is not yet fully understood. This allows the germs to colonize the prostate permanently. Antibiotics also have relatively little effect on prostate tissue, which may encourage the bacteria to survive in the prostate.

So, please discuss your case with your doctor.

I had prostatitis symptoms for decades and took doxycycline for many years, which would clear it up, until the next time! It wasn't until I got in touch with a couple of professors of urology (one in Sydney and one in London) and they had been studying this for quite a few years and recommended Monural (fosfomycin), every three days and with the addition of doxycycline if it didn't appear to be getting any better.

 

They also studied the activity of bacterial biofilms which in effect shield the bacteria from the likes of antibiotics, which is why some antibiotics don't work at all.

 

So my days of prostatitis were over, that is until I got an E. coli infection and the hospital recommended an IV Carbapenem, so I had to go to the hospital every day for seven days (or was it 10 days?) and that cleared it up, but it was very expensive, with the full treatment costing just over 50,000 baht.

 

Now I have to be very careful and because I have a neurogenic bladder which doesn't empty, I am susceptible to infections of one form or another, although the Monurol has cleared up the majority of the infections and I haven't had to have the Carbapenem treatment again (thankfully).

 

Before I was prescribed Carbapenem, the urologist at the hospital kept giving me different antibiotics without taking a sample/culture, however it kept getting worse and I was feeling really bad, yet he persisted with other antibiotics and I became very sick because of the E. coli infection. It wasn't until I saw another urologist that I was able to get on the Carbapenem treatment.

 

This original urologist put me on just about every antibiotic I could think of, including a fluoroquinolone (ciprofloxacin) which affected my Achilles tendon, so I could hardly walk. All in all it was a very unpleasant experience and I never went back to the original urologist.

 

In summary, I now keep Monurol on standby just in case I get another flareup.

[newbee2022]

1 hour ago, xylophone said:

 

I had prostatitis symptoms for decades and took doxycycline for many years, which would clear it up, until the next time! It wasn't until I got in touch with a couple of professors of urology (one in Sydney and one in London) and they had been studying this for quite a few years and recommended Monural (fosfomycin), every three days and with the addition of doxycycline if it didn't appear to be getting any better.

 

They also studied the activity of bacterial biofilms which in effect shield the bacteria from the likes of antibiotics, which is why some antibiotics don't work at all.

 

So my days of prostatitis were over, that is until I got an E. coli infection and the hospital recommended an IV Carbapenem, so I had to go to the hospital every day for seven days (or was it 10 days?) and that cleared it up, but it was very expensive, with the full treatment costing just over 50,000 baht.

 

Now I have to be very careful and because I have a neurogenic bladder which doesn't empty, I am susceptible to infections of one form or another, although the Monurol has cleared up the majority of the infections and I haven't had to have the Carbapenem treatment again (thankfully).

 

Before I was prescribed Carbapenem, the urologist at the hospital kept giving me different antibiotics without taking a sample/culture, however it kept getting worse and I was feeling really bad, yet he persisted with other antibiotics and I became very sick because of the E. coli infection. It wasn't until I saw another urologist that I was able to get on the Carbapenem treatment.

 

This original urologist put me on just about every antibiotic I could think of, including a fluoroquinolone (ciprofloxacin) which affected my Achilles tendon, so I could hardly walk. All in all it was a very unpleasant experience and I never went back to the original urologist.

 

In summary, I now keep Monurol on standby just in case I get another flareup.

The question; what kind of prostatistis?

Two I described already. Here the third:

If chronic abacterial prostatitis (chronic pelvic pain syndrome) is present, antibiotic therapy is usually ineffective. In the case of inflammatory chronic pelvic pain syndrome, it is worth trying antibiotics despite the lack of evidence of a pathogen, as improvement can sometimes be achieved. In the case of non-inflammatory chronic pelvic pain syndrome, however, doctors do not recommend antibiotic therapy. Other treatment approaches for chronic abacterial prostatitis are so-called 5α-reductase inhibitors such as finasteride or dutasteride, pentosan polysulfate and herbal medicines (phytotherapeutics) such as quercetin or pollen extract. If these do not achieve improvement, medical therapy is supplemented with physical therapy. Exercise therapy, pelvic floor exercises or regular prostate massage are recommended here. Microwave heat therapy can also be used to stimulate increased blood flow to the tissue, which reduces pain.

Do you think you suffer from abacterial prostatitis? In many cases patients are a bit lazy with exercises.

Only labs can find out.

[xylophone]

29 minutes ago, newbee2022 said:

The question; what kind of prostatistis?

Two I described already. Here the third:

If chronic abacterial prostatitis (chronic pelvic pain syndrome) is present, antibiotic therapy is usually ineffective. In the case of inflammatory chronic pelvic pain syndrome, it is worth trying antibiotics despite the lack of evidence of a pathogen, as improvement can sometimes be achieved. In the case of non-inflammatory chronic pelvic pain syndrome, however, doctors do not recommend antibiotic therapy. Other treatment approaches for chronic abacterial prostatitis are so-called 5α-reductase inhibitors such as finasteride or dutasteride, pentosan polysulfate and herbal medicines (phytotherapeutics) such as quercetin or pollen extract. If these do not achieve improvement, medical therapy is supplemented with physical therapy. Exercise therapy, pelvic floor exercises or regular prostate massage are recommended here. Microwave heat therapy can also be used to stimulate increased blood flow to the tissue, which reduces pain.

Do you think you suffer from abacterial prostatitis? In many cases patients are a bit lazy with exercises.

Only labs can find out.

Initially I was tested (back in the 80s) and diagnosed with non-specific urethritis, which as you know is a term which really means "they don't know what's causing it/they can't isolate the cause". However this kept re-occurring and when I moved to NZ, I visited a couple of top urologists and two fabulous doctors and was put on a 90 day course of doxycycline (yes, 90 days) and this stopped it for a while, until it re-occurred.

 

The symptoms were burning in the urethra and a testicle ache, but nothing else of any note. I was put on a months course of ciprofloxacin and that stopped it for a while as well, but again it re-occurred and I had no idea why. Prostatitis was the diagnosis, but maybe this was just a shot in the dark, so to speak.

 

When I contacted the two professors I spoke about previously and looked at their research (they sent me the papers they had published) it became clear to me that I had bacteria in the prostate which couldn't be reached because of the biofilm and the fact that the prostate is designed to protect itself from bacteria, so along with the biofilm, no antibiotics were able to reach the culprit.

 

However I did try their recommendation of Monural and doxycycline, and that combination worked and I haven't suffered from that for many years now.

 

The episode with the E. coli was separate from the above and was a result of my neurogenic bladder.

 

In summary, I went to the best urologists in New Zealand along with two great doctors, and two urologists here and it wasn't until I got in touch with the professors (already mentioned) that I was able to be free of it.

 

As for your question "what kind of prostatitis", well I was never given a clear explanation of what I had, however I don't suffer from it any more so am pleased about that, now got to try and find a way to activate the detrusor in my bladder, so I'm going to try stem cells as nobody seems to be able to cure it, so it's a long shot and there's nothing much else I can try I'm afraid.

 

Sorry to have gone off track a little.