Thailand Launches Major Dengue Vaccine Trial in Children

[snoop1130]

File photo for reference only

 

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

 

Endorsed by the National Communicable Disease Committee, this study seeks to evaluate the vaccine's effectiveness, with hopes of integrating it into Thailand's universal healthcare system upon completion. Director General of the Department of Disease Control, Dr Panumas Yanawetsakul, revealed that the testing is expected to conclude in three years, paving the way for the vaccine's inclusion in the healthcare programme.

 

Developed by a Japanese pharmaceutical company, the vaccine is a live-attenuated type, similar to the measles vaccine and already registered with the Thai FDA. Although promising, Dr Nakorn Premsri, leader of the National Vaccine Institute, cautions that its integration into the national healthcare scheme will require careful review, weighing the test results against cost-effectiveness.

 

 

While dengue vaccines are currently available in Thailand, they are primarily offered by private healthcare providers at significant cost. This government initiative aims to make dengue immunisation accessible and affordable to millions.

 

Endemic in over 100 countries, dengue fever remains a major health concern, especially in tropical areas like Thailand. The vaccine trial, therefore, is a critical effort to reduce infections and lessen the strain on the healthcare system. With Thailand reporting thousands of cases yearly, health experts are hopeful that a successful trial will lead to widespread immunisation, ultimately saving numerous lives.

 

The government is dedicated to monitoring the trial's progress and ensuring that, if successful, the vaccine quickly becomes part of public healthcare, reported The Thaiger.

 

-- 2025-03-14

 

 

[Stiddle Mump]

It's not in the 'off the beaten track' section. But I'll risk posting.

 

All I can say is; ''poor kids.''

[Lacessit]

11 minutes ago, Stiddle Mump said:

It's not in the 'off the beaten track' section. But I'll risk posting.

 

All I can say is; ''poor kids.''

Why worry? According to you, viruses don't exist.

[johng]

And no mention of "safety" precautions in the report above just money and that it "will save numerous lives" as if its a forgone conclusion.

They should be mindful of what has happened with live attenuated Polio vaccines. 

[Lacessit]

2 hours ago, johng said:

And no mention of "safety" precautions in the report above just money and that it "will save numerous lives" as if its a forgone conclusion.

They should be mindful of what has happened with live attenuated Polio vaccines. 

Polio is still endemic in Afghanistan.

 

The country has one of the highest infant mortality rates in the world. Ignorant mullahs are mainly responsible for vaccine resistance.

 

The only notable  side effect I seem to have from my multiple vaccinations is a low tolerance of fools.

[connda]

3 hours ago, snoop1130 said:

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

...regardless of prior exposure to dengue?  You gotta be kidding?
That's irresponsible.  Antibody Dependent Enhancement affecting those who previously had Dengue are a dangerous and documented issue with of Dengue vaccines. It's also why as second infection of Dengue can kill you.  I hope they don't end up killing some of these children.  These kids need to be carefully screened prior to receiving the vaccine.  But it sounds like they are going to go "full speed ahead and damn the torpedoes."  So what if they kill some of the children of the peasant class.
Good lord.

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
"For the enhanced vaccine safety, all dengue vaccine candidates should be assessed for the extent of type-specific (minimal ADE) vs. cross-reactive (ADE promoting) neutralizing antibodies. The type-specific EDIII antibodies may be more directly related to protection from disease in the absence of ADE promoted by the cross-reactive antibodies."

https://pmc.ncbi.nlm.nih.gov/articles/PMC7642463/

[ronnie50]

The article didn't mention the brand - but clearly the study refers to the QDenga Vaccine marketed by a Japanese pharma. It's already approved by the Thai FDA as mentioned, and is also approved the European Medicines Agency - EMA (the EU's FDA) and other countries.

 

It's easily available at private hospitals here, so I don't think there's anything to worry about for the kids. It's approved for anyone 4 years of age and above by the EMA - no upper age limit for Europe. In Thailand they stick to 4 - 60 years of age. (The only reason 60 is the upper age limit is due to an abundance of caution recommended by the manufacturer as QDenga's trials didn't involve anyone older than that).

 

It's two shots/jabs spaced over 3 months. It isn't cheap though, as mentioned. So I'm not really sure what this Thai 'vaccine trial' is all about. How would reproducing the Qdenga Japanese trials on kids 7 - 10 make it any cheaper for Thailand? It seems an odd thing to do (unless they don't trust the original trials by the manufacturer). Regarding older people, the Japanese trials focused only on mere hundreds, compared to many thousands of younger kids, who are more vulnerable to dengue (by being outdoors more than older working-age people).

[connda]

1 hour ago, connda said:

...regardless of prior exposure to dengue?  You gotta be kidding?
That's irresponsible.  Antibody Dependent Enhancement affecting those who previously had Dengue are a dangerous and documented issue with of Dengue vaccines. It's also why as second infection of Dengue can kill you.  I hope they don't end up killing some of these children.  These kids need to be carefully screened prior to receiving the vaccine.  But it sounds like they are going to go "full speed ahead and damn the torpedoes."  So what if they kill some of the children of the peasant class.
Good lord.

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
"For the enhanced vaccine safety, all dengue vaccine candidates should be assessed for the extent of type-specific (minimal ADE) vs. cross-reactive (ADE promoting) neutralizing antibodies. The type-specific EDIII antibodies may be more directly related to protection from disease in the absence of ADE promoted by the cross-reactive antibodies."

https://pmc.ncbi.nlm.nih.gov/articles/PMC7642463/

 

1 hour ago, ronnie50 said:

The article didn't mention the brand - but clearly the study refers to the QDenga Vaccine marketed by a Japanese pharma.

I've got it backwards.  If you've had Dengue that vaccine is recommended up to 60.  The ADE risk comes from vaccinating someone who never had Dengue and then contracts Dengue after the vaccination.  I looked into this a few years back and now remember that I was over the age limit but having had Dengue before, fit that checkbox.

Too bad they didn't provide the vaccine's name and manufacturer.  I'd be interested in knowing what it is.  Still - if they are vaccination all these kids without addressing ADE reactions - well, my humble opinion - it borders on criminal. No doubt the parents will be told it's 100% safe and to sign the liability waivers ("don't bother to read them") providing the researchers and vaccine manufacturer with indemnity.

Per QDenga:

[hotsun]

I had dengue before. I didnt know what it was when i had it, thought i was dying

[cdemundo]

14 hours ago, Stiddle Mump said:

They don't; but those filthy jabs do.

 

The OP mentioned 'measles'. Just to point out that measles was fatal for 1 in 500,000, before the jab was introduced into the US. Pretty soon after, that ratio went to 1 in 10,000. Now it's even less. The UK's NHS say measles kills one in 100.

 

Hello!! Any white-coats listening?

Doubling down on the claim that viruses don't exist?

Idiot or moron? Possibly a member of both groups?

[ChaiyaTH]

When you are no longer sleeping and you read headlines like 'doing a trial on kids' and that to be entirely regular news and normal. Well great they do this trial on kids, just not on my kid. Ciao. 

We all lived until today without it since humans exist so I guess we can also see trough the trials + 10 year later effects first then. No need to rush and get it yourself in that case at all.  It's unreal how many shots I am offered in Thailand for my son each time we visit (outside regular ones). 

They even offered a flu shot half a year ago, I looked at her as if she had lost her mind. Giving flu shots to healthy kids, wtf.

[hotchilli]

17 hours ago, snoop1130 said:

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

Do the kids/parents/guardians have the right to say no way?

[Captain Flack]

A troll post in all bold and changing a quote from English has been removed. @Adam Tomaszewski

[stevenl]

17 hours ago, Lacessit said:

Polio is still endemic in Afghanistan.

 

The country has one of the highest infant mortality rates in the world. Ignorant mullahs are mainly responsible for vaccine resistance.

 

The only notable  side effect I seem to have from my multiple vaccinations is a low tolerance of fools.

Science denying nutters. They're often driven by religion, like Afghanistan, Iran, bible belt.

[Sheryl]

This is not a clinical trial of vaccine efficacy or safety.

 

The vaccine in question has already completed such studies and is already approved for use in many countries, including Thailand.

 

 It does not have the problems associated with use in people who have never had dengue which were seen in earlier dengue vaccines. 

 

The study is of cost effectiveness to determine if it is economically  advisable to offer this vaccine free of charge through the public health system. Currently it must be paid for out of pocket. 

[Stiddle Mump]

4 minutes ago, Sheryl said:

This is not a clinical trial of vaccine efficacy or safety.

 

The vaccine in question has already completed such studies and is already approved for use in many countries, including Thailand.

 

 It does not have the problems associated with use in people who have never had dengue which were seen in earlier dengue vaccines. 

 

The study is of cost effectiveness to determine if it is economically  advisable to offer this vaccine free of charge through the public health system. Currently it must be paid for out of pocket. 

''Thailand Launches Major Dengue Vaccine Trial in Children.''

 

OP suggests that it is a trial of a vaccine; using 35k kids.

[Sheryl]

6 minutes ago, Stiddle Mump said:

''Thailand Launches Major Dengue Vaccine Trial in Children.''

 

OP suggests that it is a trial of a vaccine; using 35k kids.

An inexact use of terms.  Possiibly stemming from an anouncrment initially made in Thai. 

 

If you read  through the article, it is a cost effectiveness study of an already tested and approved vaccine. 

[Captain Flack]

I have removed multiple posts and replies. This is the News Section, where claims of alternative facts, need to be supported by links.

 

Comments like “You could do worse than read my musings. I know what I'm talking about” are ok in the “off the beaten track” section, but are worthless here if unsupported.

[Captain Flack]

14 minutes ago, Captain Flack said:

I have removed multiple posts and replies. This is the News Section, where claims of alternative facts, need to be supported by links.

 

Comments like “You could do worse than read my musings. I know what I'm talking about” are ok in the “off the beaten track” section, but are worthless here if unsupported.

I made the above comments, to stop the deflection of this topic.

 

Yet my moderation comment has been ignored, and replies to removed posts continue.

 

Can I suggest it stops now or posters can expect further moderation action.

[Wongkitlo]

A mosquito awareness program would help as well. My neighbour always left water around and we had many mosquitoes till her daughter contracted dengue. Now no water- no mosquitoes. Pity Thais need to learn the hard way. If they did not leave rubbish everywhere there would be less places for rainwater to gather and less mosquitoes. 

[ronnie50]

We had a Thai neighbor who left a really big concrete planter full of water - never changed for a year - for the squirrels she said. One hot day I emptied it and she got p!ssed off and so I refilled it. 

 

A couple of months later I got dengue that landed me in hospital for a week. A month after that a live-in relative at our place got sick with dengue and went to a government hospital. He was there 5 days until passing through the febril period and starting to recover. We're sure it was from that huge planter of water. Big mossies would fly around our place all day long. My platelets dropped to 24,000 before recovering. My relative's platelets dropped to just 7,000 before recovering! (likely his secondary infection and my primary). Dengue is a serious, serious issue in Bangkok.