Your article talks about KhonKaen. That's a big city.
It is an article about " Thai food". Not Isaan food.
You've already pointed out certain areas have more choice. I agree.
In my experience of living in Issan; Korat, MSK, Buriram, Surin, KhonKean, Kalasin, Yasothon, Amnat Charoen, Roiet, Sissaket all have great markets, both night and day. All places have Makro and BigC. Some have Robinson with Tops. Your 95% and use of the word " most" are inverted.
I don’t remember seeing the mass deaths from diet or boredom. Maybe you can show evidence.
Really. If you truly believe what you say, move. Simple.