Pfizer booster after two Sinovac jabs are most effective against Delta, Omicron

[snoop1130]

 

Two doses of Sinovac and a booster dose of Pfizer vaccines generate the highest level of immune response against the Delta and Omicron variants, measured at 1,143 Geometric Mean Titer (GMT) and 531 GMT respectively, according to initial findings from Siriraj Clinical Research Centre.

 

The centre conducted studies on the use of Pfizer, both full and half doses, and AstraZeneca as a booster jab for people already inoculated with two doses of Sinovac or AstraZeneca vaccines, assess the immune response to the Delta and Omicron variants.

 

The findings include:

 

• Two Sinovac doses and half a dose of Pfizer booster generate an immune response measured at 1,002 GMT against Delta and 507 GMT against the Omicron variant.
• Two Sinovac doses and one full dose of Pfizer booster generate an immune response measured at 1,143 GMT against Delta and 531 GMT against the Omicron variant.
• Two AstraZeneca doses and half a dose of Pfizer generate a 674 GMT immune response against Delta and a 232 GMT immune response against Omicron.
• Two AstraZeneca doses and one full dose of Pfizer vaccine produce a 917 GMT immune response against Delta and a 521 GMT immune response against Omicron.
• Three AstraZeneca vaccine doses generate a 121 GMT immune response against Delta and 22 GMT against Omicron.

 

Full Story: https://www.thaipbsworld.com/research-indicates-two-sinovac-jabs-then-pfizer-booster-are-most-effective-against-delta-omicron/

 

-- © Copyright Thai PBS 2022-01-12

 

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[Pattaya Spotter]

I hope it's the same for Sinovac + AZ and Pfizer because I'm getting my booster on Friday.

[The Hammer2021]

3 minutes ago, Pattaya Spotter said:

I hope it's the same for Sinovac + AZ and Pfizer because I'm getting my booster on Friday.

Oh where? How?

[Pattaya Spotter]

3 minutes ago, The Hammer2021 said:

Oh where? How?

Phuket.win  (Yellow tab at the bottom...boosters for foreigners)

 

https://xn--12cmj6ba0a7b3g4a6fud5d2a.com/

Edited January 12, 2022 by Pattaya Spotter

[stigar]

Im happy i stay in my home country.Go my 3rd phizer last friday.We have drop in also for booster for people age 45+

[Bkk Brian]

28 minutes ago, snoop1130 said:

The findings include:

 

• Two Sinovac doses and half a dose of Pfizer booster generate an immune response measured at 1,002 GMT against Delta and 507 GMT against the Omicron variant.
• Two Sinovac doses and one full dose of Pfizer booster generate an immune response measured at 1,143 GMT against Delta and 531 GMT against the Omicron variant.
• Two AstraZeneca doses and half a dose of Pfizer generate a 674 GMT immune response against Delta and a 232 GMT immune response against Omicron.
• Two AstraZeneca doses and one full dose of Pfizer vaccine produce a 917 GMT immune response against Delta and a 521 GMT immune response against Omicron.
• Three AstraZeneca vaccine doses generate a 121 GMT immune response against Delta and 22 GMT against Omicron.

I'll go with the data from Yale University study and the Hong Kong Study:

 

According to the study again, a two-dose injection of Sinovac followed by an injection of a Pfizer-BioNTech booster dose only produced antibodies similar to two doses of Ribonucleic Acid or mRNA Messenger type vaccine.

The antibody level to Omicron was 6.3 times lower when compared to the original variant and 2.7 times lower when compared to Delta.

One of the researchers, Akiko Iwasaki, said in a tweet on Twitter that the CoronaVac vaccine recipients may need two more booster doses to achieve a level of protection against Omicron.

 

https://asianewstoday.com/sinovac-dose-pfizer-booster-dose-is-less-effective-against-omicron/

 

Or from Edinburgh University:

 

“The good news is that whether you had AZ or Pfizer as your first two doses and whether you have Pfizer or Moderna as your booster, there is a marked increase in both your neutralising antibody concentration (on average a more than 20-fold increase) and your T cell response (on average an approximately 3 fold boost) against both the original Wuhan virus and against the Delta variant.

 

https://www.sciencemediacentre.org/expert-reaction-to-cov-boost-study-investigating-safety-and-immunogenicity-of-seven-covid-19-vaccines-as-a-third-dose-following-two-doses-of-either-oxford-astrazeneca-or-pfizer/

 

 

 

Edited January 12, 2022 by Bkk Brian

[The Hammer2021]

6 minutes ago, Bkk Brian said:

I'll go with the data from Yale University study and the Hong Kong Study:

 

According to the study again, a two-dose injection of Sinovac followed by an injection of a Pfizer-BioNTech booster dose only produced antibodies similar to two doses of Ribonucleic Acid or mRNA Messenger type vaccine.

The antibody level to Omicron was 6.3 times lower when compared to the original variant and 2.7 times lower when compared to Delta.

One of the researchers, Akiko Iwasaki, said in a tweet on Twitter that the CoronaVac vaccine recipients may need two more booster doses to achieve a level of protection against Omicron.

 

https://asianewstoday.com/sinovac-dose-pfizer-booster-dose-is-less-effective-against-omicron/

 

Or from Edinburgh University:

 

“The good news is that whether you had AZ or Pfizer as your first two doses and whether you have Pfizer or Moderna as your booster, there is a marked increase in both your neutralising antibody concentration (on average a more than 20-fold increase) and your T cell response (on average an approximately 3 fold boost) against both the original Wuhan virus and against the Delta variant.

 

https://www.sciencemediacentre.org/expert-reaction-to-cov-boost-study-investigating-safety-and-immunogenicity-of-seven-covid-19-vaccines-as-a-third-dose-following-two-doses-of-either-oxford-astrazeneca-or-pfizer/

 

 

 

Ah that's useful. I had AZx2 now need to know best booster. I have a choice of M or P. So I guess either will be OK. I'm in Pattaya  today  was offered chance to book Moderna, 1600bht but EDD March..but I'm due 26 Jan on a 3 month cycle.

[EricTh]

What is this GMT immune response thing? Is this a new invention?

 

I wonder any big pharma companies paid for this new terminology.

Edited January 12, 2022 by EricTh

[rbkk]

Why did they not trial Moderna? it's an available booster option in Thailand.

[smedly]

who to believe, Thailand seems to have a tendency to make many claims that are never submitted for peer review and therefore are simply words that are meaningless

[EricTh]

49 minutes ago, cyril sneer said:

 

If Sinovac is ineffective, please explain scientifically how Indonesia's rate of infection is so low recently (past four months) considering it has the same population size as the USA with a lower vaccination rate.

 

https://www.worldometers.info/coronavirus/country/indonesia/

 

I won't even mention other countries which use mostly Sinovac/Sinopharm with similar results.

 

Indonesia use mostly Sinovac unlike Thailand. 

 

[Moonlover]

My wife and I received ours yesterday at our local village health clinic. I was double AZ, she was Coronavac plus AZ.

[smedly]

who to believe, Thailand seems to have a tendency to make many claims that are never submitted for peer review and therefore are simply words that are meaningless

[The Hammer2021]

10 minutes ago, EricTh said:

If Sinovac is ineffective, please explain scientifically how Indonesia's rate of infection is so low recently (past four months) considering it has the same population size as the USA with a lower vaccination rate.

 

https://www.worldometers.info/coronavirus/country/indonesia/

 

I won't even mention other countries which use mostly Sinovac/Sinopharm with similar results.

 

Indonesia use mostly Sinovac unlike Thailand. 

 

The sinovac/parm debate really fired the imagination  of the mainly non resident Thai haters and bitter Thai  bashers...lol Don't get em started on brown envelopes, lady boys and wipp offs....lol

[ozimoron]

I've had the gold standard, one AZ, one Pfizer and one Moderna. One of my friends thinks he had omicron last week and his GP agreed although he did not get tested. A PCR test in my state in Australia requires lining up for hours to get a result several days later and rapid test kits are unavailable.

[MrJ2U]

1 hour ago, snoop1130 said:

according to initial findings from Siriraj Clinical Research Centre.

Thats convenient.

 

I assume another huge order of Chinese vaccines is being planned behind closed doors.

 

This will soften the blow in their minds.

[MrJ2U]

37 minutes ago, rbkk said:

Why did they not trial Moderna? it's an available booster option in Thailand.

There so little they didn't want to waist it. 

Edited January 12, 2022 by MrJ2U

[Blumpie]

Booster from Sinovac?  

That's one way to put it.  

Allow me to put it another way.  Sinovacs efficacy against coronavirus is nothing short of,, um, interesting... If you put something that works in your arm the results are astounding!

[TallGuyJohninBKK]

Quote

Two doses of Sinovac and a booster dose of Pfizer vaccines generate the highest level of immune response against the Delta and Omicron variants,

 

Except, their little comparison list above seems to have entirely avoided any mention of what happens when you use the Moderna vaccine as the third booster dose.

 

And likewise, no mention of what produces the best results when people have had two initial doses of Moderna or two initial doses of Pfizer followed by a booster dose of one or the other.

 

The comparisons they're doing are a pretty blinkered look.

 

[bang saen guy]

1 hour ago, The Hammer2021 said:

Ah that's useful. I had AZx2 now need to know best booster. I have a choice of M or P. So I guess either will be OK. I'm in Pattaya  today  was offered chance to book Moderna, 1600bht but EDD March..but I'm due 26 Jan on a 3 month cycle.

Where was Moderna in March offered? I've had my Moderna booster. Just thinking about putting a few in the bank for family or friends

[ozimoron]

4 minutes ago, TallGuyJohninBKK said:

 

Except, their little comparison list above seems to have entirely avoided any mention of what happens when you use the Moderna vaccine as the third booster dose.

 

And likewise, no mention of what produces the best results when people have had two initial doses of Moderna or two initial doses of Pfizer followed by a booster dose of one or the other.

 

The comparisons they're doing are a pretty blinkered look.

 

I suspect that they reasoned that the difference between Moderna and Pfizer as a booster after Sinovac would not have produced drastically different results. Easier to just choose one or the other as it halved the number of subjects required for the trial.

[smedly]

Three AstraZeneca vaccine doses generate a 121 GMT immune response against Delta

 

 

 

I wonder what AZ would say about that 

[The Hammer2021]

9 minutes ago, bang saen guy said:

Where was Moderna in March offered? I've had my Moderna booster. Just thinking about putting a few in the bank for family or friends

Today at BPH I was offered it. Ground floor

[bang saen guy]

Just now, The Hammer2021 said:

Today at BPH I was offered it. Ground floor

Gracias

[TallGuyJohninBKK]

The other thing medical experts would say about these kinds of government-issued reports and the news coverage of them is that while antibody levels as measured in the blood are ONE indicator of a person's resistance to a virus, they're not the only physiological factor that influences such things. There's also B cell and T cell levels and various other stuff.

 

Suffice to say, you can't really measure how effective a vaccine or booster is in preventing infection in the real world just by measuring blood antibody levels. That's why they do the cohort studies that actually measure the shares of vaccinated people who do and don't get infected post-vaccination.

 

[onthedarkside]

A series of off-topic trolling, flaming and bickering posts and replies have been removed.

 

[The Hammer2021]

3 minutes ago, bang saen guy said:

Gracias

just pass the SP bakery en route  to cashier

[MrJ2U]

1 hour ago, ozimoron said:

halved the number of subjects required for the trial.

There is no mention of how many people were in the control groups.

 

With 55 million doses used to vaccinate Thais with Sinovac, finding participants should be no problem.

 

Why no Sinopharm should be another question.

 

 

Edited January 12, 2022 by MrJ2U

[ozimoron]

20 minutes ago, MrJ2U said:

There is no mention of how many people were in the control groups.

 

With 55 million doses used to vaccinate Thais with Sinovac, finding participants should be no problem.

 

Why no Sinopharm should be another question.

 

 

I didn't say it was problem finding them. I said it would double the work load for minimal gain. I think it can safely be said that the difference between Pfizer and Moderna as a booster would be minimal and they probably know that..

[MrJ2U]

39 minutes ago, ozimoron said:

I didn't say it was problem finding them. I said it would double the work load for minimal gain. I think it can safely be said that the difference between Pfizer and Moderna as a booster would be minimal and they probably know that..

It doesn't mention how many people participated in the study.

 

The whole thing sounds like a very badly done study to promote Thailand's use of Sinovac and Astra Zeneca.