Thailand Successfully Produced The World's First Vaccine Against Dengue Fever

[webfact]

Thailand successfully produced the world's first vaccine against dengue fever

BANGKOK, 21 February 2011 (NNT)-Thailand’s National Science and Technology Development Agency (NSTDA) is full of praise for a team of scientists who have successfully produced a vaccine against dengue fever, while showing confidence that the vaccine it will be ready for human treatment within the next 3 years.

According to Ministry of Science and Technology Dr. Veerachai Veerametheekul, the vaccine has been developed with the collaboration of researchers consisting of Dr. Poonsuk Keerapang from the Chiang Mai University, Associate Professor Dr. Nopporn Sittisombut, the National Center for Genetic Engineering and Biotechnology and Associate Professor Dr. Suthee Yoklan from Mahidol University.

The success, funded by the NSTDA, has been hailed as the world’s first dengue fever vaccine; however, the vaccine has so far been proven effective in mice, and has yet to be tested on human. According to the report, the vaccine will be further developed and tested in human by Bio Net Asia Company Limited and is expected to be available in the next 3 years.

-- NNT 2011-02-21

[bunnaag]

It was not mentioned if this vaccine will protect against all 3 types of dengue fever.

[diehard60]

It was not mentioned if this vaccine will protect against all 3 types of dengue fever.

You are right and Thailand is trying to be first in something good for a change.

[Old Croc]

Not sure it's the first, but lets hope someone gets it on the market very soon.

Vaccine

[SomTumTiger]

Good news, which will be quickly dismissed as an aberration, because Thailand's universities are all crap - according to the experts on TV.

[janverbeem]

Did they forget to add that Thailand will be the hub of dengue fever vaccine or do just have to expect this as a normality.

[Scott]

Not sure it's the first, but lets hope someone gets it on the market very soon.

Vaccine

Any updates on the status of that vaccine? It's already in human trials, so unless it has failed, it would be the first.

[Tokay]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

[Nisa]

Not sure it's the first, but lets hope someone gets it on the market very soon.

Vaccine

Any updates on the status of that vaccine? It's already in human trials, so unless it has failed, it would be the first.

The other newspaper says they have only tested it on animals and it will not likely be on the market for 10-years.

However France is supposed to have theirs out by 2015 and and is already be tested including on children in Thailand This was in the news a week or so ago and they too say it is the first and this actually appears more accurate given it is scheduled for market sooner, being tested on humans and claims to have a 90% effectiveness against the assumed 80% on humans the Thai vaccine is assumed to have on people.

Would seem the Thais might be a bit bummed about the latest news of the French Vaccine beating theirs at a Global Dengue Vaccine Conference held recently.

[bridge]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Mmmm no thanks I will just ride the Dengue out

Jokes aside, great development - well done.

[slapout]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Hell, they should use this stuff for prisoner interrogation purposes. Having had dengue, the symptoms were a piece of cake, compared to the note above.

[whybother]

Did they forget to add that Thailand will be the hub of dengue fever vaccine or do just have to expect this as a normality normalcy.

** edited quote.

?????????????

http://dictionary.re...rowse/normality

It's a Thai politics thing. One example: http://www.bbc.co.uk/news/world-asia-pacific-11013665

[asiawatcher]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Mmmm no thanks I will just ride the Dengue out

Jokes aside, great development - well done.

Doubt it Bridge - Pappaya Leaves juiced do exactly the same thing - look it up - and they taste like crap but knock the fever over easily and you don't need to get million dollar grants to make Big Pharma richer. Been known for decades. Just another way to make the rich richer and use the rest of us as mugs to absorb their poisons. Using a vaccine to bypass the immune system is the quickest way to shut you down and open the rest of you to more diseases. Apart from possible creating autism in kids etc. No - not well done - never.

[robsamui]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Seeing you know all about these things - I've never seen a mouse with an erection - what's it look like? (And they sure have a short attention span anyway!)

R

Edited February 21, 2011 by robsamui

[jayjay0]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

You omitted athletes foot.

[webfact]

Bio Net Asia given rights to develop dengue-fever vaccine

By Jutharat Thipnampa

The Nation

After 30 years of research, the National Science and Technology Development Agency (NSTDA) has passed on the technology of producing a dengue-fever vaccine to the private sector, which will take up to 10 years developing the vaccine for commercial use and have it ready for tests on large animals.

If successful, this live-attenuated recombinant vaccine - the third-generation vaccine developed from a prototype created by Mahidol and Chiang Mai University in the 30-year study that was funded by the NTSDA - would be the first of its kind in the world.

President of Bio Net Asia, Withoon Wonghankul, said yesterday that the NTSDA had given his company the right to develop the vaccine, which would cover four virus strains in one shot. He added that the vaccine strain from the NTSDA research had high potential in being developed commercially, even though it might take up to 10 years to produce and be ready for tests on large animals. Bio Net Asia has spent the past decade producing as well as importing and exporting vaccines. It is currently producing a vaccine for pertussis, a highly contagious bacterial disease that causes uncontrollable coughing.

Meanwhile, Chiang Mai University researcher Dr Poonsuk Keerapang said the dengue-fever vaccine was developed by using genetic engineering to create a hybrid strain of viruses found in Thailand, so it could prevent illnesses from four different virus strains at the same time.

Dr Suthee Yoksan, a researcher from Mahidol University, said about 600,000 people or 1 per cent of the Thai population suffered from dengue fever, with a third of the patients developing symptoms and a fifth of them dying.

-- The Nation 2011-02-22

[glegolo]

This surprice me as well big time. Thailand, nation of copying stuff, has never been first on anything yet in the worlds history, so why now with that quality of their schoolsystem.

No way!!!

Glegolo

[Nisa]

This surprice me as well big time. Thailand, nation of copying stuff, has never been first on anything yet in the worlds history, so why now with that quality of their schoolsystem.

No way!!!

Glegolo

You appear to be right ... http://flashnewstoday.com/index.php/effective-vaccine-for-dengue-by-2015/

[geriatrickid]

<deleted> is going on?

Sanofi announce on Feb 19 that it was starting its tetravalent pediatric clinical trials in Thailand and it is being done in conjunction with the MOH and Mahidol.

The company named in the news article is not a developer of vaccines. It is a marketer. It also provides logistics and it can provide local technical support, but it has no proprietary vaccine R&D footprint that I know of. All of the vaccine manufacturers involved in dengue vaccine development in Thailand are either GSK, Sanofi or foreign niche biotechs using actives licensed licensed from the United States NIH

This is a very odd announcement. It is possible someone has taken something out of context.

The two key dengue vaccine hubs in Thailand are AFRIMS Virology Research Unit (KAVRU)@ Kamphaeng Mahidol University @ Ratchburi.

Is it possible someone is mixing up activities and is confused? Why would Mahidol compete against itself after working closely with Sanofi and the U.S. NIH all this time?

[Nisa]

<deleted> is going on?

Sanofi announce on Feb 19 that it was starting its tetravalent pediatric clinical trials in Thailand and it is being done in conjunction with the MOH and Mahidol.

The company named in the news article is not a developer of vaccines. It is a marketer. It also provides logistics and it can provide local technical support, but it has no proprietary vaccine R&D footprint that I know of. All of the vaccine manufacturers involved in dengue vaccine development in Thailand are either GSK, Sanofi or foreign niche biotechs using actives licensed licensed from the United States NIH

This is a very odd announcement. It is possible someone has taken something out of context.

The two key dengue vaccine hubs in Thailand are AFRIMS Virology Research Unit (KAVRU)@ Kamphaeng Mahidol University @ Ratchburi.

Is it possible someone is mixing up activities and is confused? Why would Mahidol compete against itself after working closely with Sanofi and the U.S. NIH all this time?

You seem to be much more up on this than most of us but I did check the recent news and see:

1- their was a Dengue conference held recently regarding the status of the vaccines

2 - Bill Gates foundation has released millions to help with the vaccines

3- France's vaccine is already being tested on people (including here in Thailand) and the ETA for its release is 2015 --

4 - based on animal trials the Thai vaccine is guessed to be 80% successful in humans while they results they are getting with the France vaccine are 90%

So, I am guessing you are either right that this is being reported incorrectly or that Thailand is trying to get on this bandwagon to merge with another group or somehow get funds into their project.

[phetaroi]

Did they forget to add that Thailand will be the hub of dengue fever vaccine or do just have to expect this as a normality.

Why not? After all, it's already a hub of dengue fever.

[Payboy]

Thailand Successfully Produced The World's First Vaccine Against Dengue Fever

the vaccine it will be ready for human treatment within the next 3 years.

So is it produced or not?

[robsamui]

<deleted> is going on?

Sanofi announce on Feb 19 that it was starting its tetravalent pediatric clinical trials in Thailand and it is being done in conjunction with the MOH and Mahidol.

The company named in the news article is not a developer of vaccines. It is a marketer. It also provides logistics and it can provide local technical support, but it has no proprietary vaccine R&D footprint that I know of. All of the vaccine manufacturers involved in dengue vaccine development in Thailand are either GSK, Sanofi or foreign niche biotechs using actives licensed licensed from the United States NIH

This is a very odd announcement. It is possible someone has taken something out of context.

The two key dengue vaccine hubs in Thailand are AFRIMS Virology Research Unit (KAVRU)@ Kamphaeng Mahidol University @ Ratchburi.

Is it possible someone is mixing up activities and is confused? Why would Mahidol compete against itself after working closely with Sanofi and the U.S. NIH all this time?

You seem to be much more up on this than most of us but I did check the recent news and see:

1- their was a Dengue conference held recently regarding the status of the vaccines

2 - Bill Gates foundation has released millions to help with the vaccines

3- France's vaccine is already being tested on people (including here in Thailand) and the ETA for its release is 2015 --

4 - based on animal trials the Thai vaccine is guessed to be 80% successful in humans while they results they are getting with the France vaccine are 90%

So, I am guessing you are either right that this is being reported incorrectly or that Thailand is trying to get on this bandwagon to merge with another group or somehow get funds into their project.

Reading between the lines here my interpretation goes something like this.

Big international drug company is working on a vaccine for dengue. As a part of this they are testing and trialling the vaccine in Mexico, Aus, S.America Vietnam and Thailand etc. One of the research workers in a Thailand university is seeing some success in the trials and is happy to announce loudly that the Thai part of the venture is doing good and that Thailand is a country to be taken seriously, by golly! Thai press (already knowing that Thailand is the tops) cheerfully prints story that Thailand is leading the world in dengue research and the whole Thai nations nods and applauds because a) none of them have any idea what's going on outside Thailand and b)they all know Thailand is a Serious Player anyway.

How's that?

R

[montrii]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Jeez I thought that was just me getting old!

[Payboy]

Reading between the lines here my interpretation goes something like this.

Big international drug company is working on a vaccine for dengue. As a part of this they are testing and trialling the vaccine in Mexico, Aus, S.America Vietnam and Thailand etc. One of the research workers in a Thailand university is seeing some success in the trials and is happy to announce loudly that the Thai part of the venture is doing good and that Thailand is a country to be taken seriously, by golly! Thai press (already knowing that Thailand is the tops) cheerfully prints story that Thailand is leading the world in dengue research and the whole Thai nations nods and applauds because a) none of them have any idea what's going on outside Thailand and b)they all know Thailand is a Serious Player anyway.

How's that?

R

Spot on! But what about the mice? Where do those fit in?

[phiphidon]

Now if they would only concentrate on coming up with something to get rid of the plague of tiny black flies that are attracted by the mango tree flowers and are really beginning to pee me off

[julemanden]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Viagra will cure all the problems i'm sure

[softgeorge]

It was not mentioned if this vaccine will protect against all 3 types of dengue fever.

You are right and Thailand is trying to be first in something good for a change.

University News

Volunteers needed to trial new vaccine against Dengue Fever

Tuesday, 21 September 2010Perth researchers are about to trial a new vaccine that aims to protect against all four strains of the potentially devastating Dengue Fever.

The vaccine is being trialled in eight centres around Australia and has been developed by one of the world's leading vaccine companies, Sanofi Pasteur.

[johnnynmonic]

Side effects include: Dizziness, headaches, loss of appetite, hair loss, loose stools, excessive urination, enlarged heart, enlarged spleen, night sweats, difficulty concentrating, night blindness, sensitivity to bright light, jaundice, increased risk for colon cancer, and difficulty achieving or maintaining an erection.

Mmmm no thanks I will just ride the Dengue out

Jokes aside, great development - well done.

Doubt it Bridge - Pappaya Leaves juiced do exactly the same thing - look it up - and they taste like crap but knock the fever over easily and you don't need to get million dollar grants to make Big Pharma richer. Been known for decades. Just another way to make the rich richer and use the rest of us as mugs to absorb their poisons. Using a vaccine to bypass the immune system is the quickest way to shut you down and open the rest of you to more diseases. Apart from possible creating autism in kids etc. No - not well done - never.

I believe the papaya leave treatment is very likely a hoax. Snopes

Edited February 22, 2011 by johnnynmonic

[jgilb]

Didn't realise this was such big news, oddly enough i was a press photographer at this event, it was covered by abc news and i spotted a few other foreign press there as well as the usual thai news networks.

Worth a look on the ABC site they had a TV camera there filming, unfortunately the whole press conference was in Thai, and as good as i am at ordering a nice kra pow i can't quite understand the talk on vaccines and viruses.