Is there any difference between Quomen and bupropion (generic). I have used sertraline (generic) and noticed a significant difference when using Zoloft for example at the same dosage. 

I’ve used both generic bupropion and Quomen, and honestly, I didn’t notice a huge difference, but I’ve read that some people feel a change depending on the brand. It might be something to do with the fillers or how your body reacts to different formulations. I’ve had a similar experience with sertraline, where I felt Zoloft had a different effect at the same dosage. If you’re noticing a real change, it could be worth chatting with your doctor to see if a switch or a different brand might work better for you.