US Army Creates Single Vaccine Against All COVID & SARS Variants, Researchers Say

[anchadian]

Within weeks, Walter Reed researchers expect to announce that human trials show success against Omicron—and even future strains

 

Within weeks, scientists at the Walter Reed Army Institute of Research expect to announce that they have developed a vaccine that is effective against COVID-19 and all its variants, even Omicron, as well as previous SARS-origin viruses that have killed millions of people worldwide. 

 

https://www.defenseone.com/technology/2021/12/us-army-creates-single-vaccine-effective-against-all-covid-sars-variants/360089/

[Boomer6969]

My guess is they managed to get hold of some Chinese army research of a few years ago.

[tgeezer]

It shouldn't be difficult to match the efficacy of what has been created so far and been given the title vaccine! 

[placeholder]

1 hour ago, tgeezer said:

It shouldn't be difficult to match the efficacy of what has been created so far and been given the title vaccine! 

What don't you understand about this?

https://ourworldindata.org/covid-deaths-by-vaccination

[catturd]

On 12/22/2021 at 11:17 PM, anchadian said:

even Omicron

I find that questionable, since it the WRAIR vaccine announced recently has not been tested on omicron.

“The Spike Ferritin Nanoparticle platform is designed to protect against an array of SARS-CoV-2 variants and SARS-origin variants but was not tested on the Omicron variant.” 

Some confusion about the announcement.

https://www.wrair.army.mil/node/659

 

[TorquayFan]

Thanks Anchadian.

 

An interesting development but because of this - "Unlike existing vaccines, Walter Reed’s SpFN uses a soccer ball-shaped protein with 24 faces for its vaccine, which allows scientists to attach the spikes of multiple coronavirus strains on different faces of the protein", I think what we are looking at is a sort of platform programmable with multiple strains of the virus, but of course, they will have to be existing strains. It may be very much quicker than rejigging Pfizer, AZ or Moderna but it's not there to cover NEW strains of course . . .

 

So the search for the 'Universal Vaccine' goes on - the CEPI (Coalition for Epidemic Preparedness), published this article in April https://cepi.net/news_cepi/going-universal-the-search-for-an-all-in-one-coronavirus-vaccine/ Towards the end of that article a small Company, Scancell, in conjunction with Nottingham Unis, have a potentially 'Universal' vaccine on trial in RSA right now.

 

Scancell's vaccine, adapted from it's 'Immunobody' vaccine for late stage Melanoma, attacks the nucleocapsid (which is very slow to mutate) as well as the spikes of the protein, generates long lasting T-cell immunity and is a 'needleless' dosing, (FDA approved Pharmajet). The UK Govt. put a paltry GBP2.7 million into this project but data from RSA expected in January.

 

We need genuine 2nd Generation vaccines as soon as possible. It'll be interesting to how SpFN and Covidity progress . . . .

Edited December 24, 2021 by TorquayFan

[Virt]

Do they think their vaccine will last longer than the current ones as well as fighting of future variants?

 

Would be nice with a new vaccine that were effective for a longer time compared to the current ones.

[Sheryl]

Work on a Corona virus vaccine with wide spectrum began back in the SARS era then funding dtied up after SARS faded away. I suspect what they did was to pick up where that had left off.

 

It is a good idea as COVID and its variants (current and future) are potentially just the beginming. There ate thousands more bat corona viruses out there  and it was recently demonstrated that several of them are already capable of directly infecting humans -- no mutation or intermediate host needed. So only a matter of time 

[TorquayFan]

Virt - interesting question. It's the T-cell immunity that lasts longest but we need anti-bodies around too please - there's signs of T-cell immunity 20 years later in S.E. Asia after Sars and Mers.

 

Here's one link : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584424/

 

So we can hope that a 2nd Generation vaccine for Covid might give 1 year or 2 years or maybe as long as the 10 years that a tetanus injection gives. Keep the faith !

 

Scancell recently received the go-ahead for it's 'Covidity' 'universal Covid vaccine trial in South Africa, using the 'Pharmajet' needleless system.

In addition, it was announced yesterday that the 'Moditope' trial has been approved in the UK to treat 4 difficult cancers :-

"The Modi-1 clinical trial will evaluate the first therapeutic vaccine candidate from the Company's novel Moditope® platform, which stimulates immune responses to stress induced post-translational modifications (siPTMs). When cells become stressed, they modify their proteins to alert the immune response that there is a problem. One of these modifications is citrullination which is the target for the Modi-1 vaccine. Fast growing cancer cells need a lot of oxygen and nutrients and are always highly stressed. Included in the Modi-1 vaccine are specific T cell epitopes derived from citrullinated vimentin, which is involved in tumour spread, and citrullinated enolase, which is an enzyme that generates nutrients to drive tumour growth. Removal of cells expressing these proteins by vaccine-specific T cells should eradicate the tumour and prevent further spread."

"Professor Lindy Durrant, Chief Executive Officer, Scancell, commented: "The approval of the Modi-1 CTA is a significant achievement for the Company. Targeting siPTMs generated dramatic regression of large tumours in our preclinical models and we hope to see similar results in cancer patients during this trial. This is the first of several vaccines that we are developing from the Moditope® platform and look forward to updating the market on our progress in due course."

A universal Covid vaccine and a new range of cancer treatments one day ? Could this be too much to hope for ?

https://www.scancell.co.uk/company

 

I hope the USA army project works. I hope Scancell's work with Covid and Cancer treatments progresses too

 

 

Edited December 25, 2021 by TorquayFan

[Virt]

2 hours ago, TorquayFan said:

Virt - interesting question. It's the T-cell immunity that lasts longest but we need anti-bodies around too please - there's signs of T-cell immunity 20 years later in S.E. Asia after Sars and Mers.

 

Here's one link : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584424/

 

So we can hope that a 2nd Generation vaccine for Covid might give 1 year or 2 years or maybe as long as the 10 years that a tetanus injection gives. Keep the faith !

 

Scancell recently received the go-ahead for it's 'Covidity' 'universal Covid vaccine trial in South Africa, using the 'Pharmajet' needleless system.

In addition, it was announced yesterday that the 'Moditope' trial has been approved in the UK to treat 4 difficult cancers :-

"The Modi-1 clinical trial will evaluate the first therapeutic vaccine candidate from the Company's novel Moditope® platform, which stimulates immune responses to stress induced post-translational modifications (siPTMs). When cells become stressed, they modify their proteins to alert the immune response that there is a problem. One of these modifications is citrullination which is the target for the Modi-1 vaccine. Fast growing cancer cells need a lot of oxygen and nutrients and are always highly stressed. Included in the Modi-1 vaccine are specific T cell epitopes derived from citrullinated vimentin, which is involved in tumour spread, and citrullinated enolase, which is an enzyme that generates nutrients to drive tumour growth. Removal of cells expressing these proteins by vaccine-specific T cells should eradicate the tumour and prevent further spread."

"Professor Lindy Durrant, Chief Executive Officer, Scancell, commented: "The approval of the Modi-1 CTA is a significant achievement for the Company. Targeting siPTMs generated dramatic regression of large tumours in our preclinical models and we hope to see similar results in cancer patients during this trial. This is the first of several vaccines that we are developing from the Moditope® platform and look forward to updating the market on our progress in due course."

A universal Covid vaccine and a new range of cancer treatments one day ? Could this be too much to hope for ?

https://www.scancell.co.uk/company

 

I hope the USA army project works. I hope Scancell's work with Covid and Cancer treatments progresses too

 

 

Thanks for info.

 

As far as i know then Moderna also hope that their mRNA technique can be used for specific cancer treatments, and it seems the mRNA tech gotten a lot of spotlight since this pandemic started.

 

So in 10 years from now i assume we will have a lot more options to fight of various diseases.

 

As Sheryl wrote it's just a matter of time before we run into another annoying virus, but by then we hopefully learnt a lot from this pandemic.

 

If we don't learn from this pandemic, then we're pretty much the dumbest thing Alive on earth.

So to speak ????

[fjb 24]

This guy (Sec-DEF) has covid.

https://www.cnn.com/2022/01/02/politics/lloyd-austin-test-positive-covid/index.html

Edited January 3, 2022 by fjb 24

[Scott]

A post violating Fair Use Policy has been removed.  

 

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https://aseannow.com/terms/

[TorquayFan]

It's not just the US Army that has a candidate for a 'Universal' covid vaccine.  Scancell, a Nottingham/Oxford based UK company have a trial in RSA currently - 'Covidity' has been developed from a successful melanoma vaccine. A mention in the Guardians '7 companies to watch in 2022' :-

 

"This spinout from the University of Nottingham, founded in 1997 by Lindy Durrant, professor of cancer immunotherapy at the university, specialises in developing cancer vaccines and has started testing them on humans. But when the pandemic struck, the company decided to modify its vaccine technology to develop Covid shots, in collaboration with Nottingham’s two universities and backed by £2m funding from the UK’s innovation agency. The vaccines aim to induce high T-cell immune responses in the body to identify and kill infected cells, as well as generating virus-neutralising antibodies."

https://www.theguardian.com/business/2022/jan/01/from-flying-taxis-to-painless-vaccines-seven-businesses-to-watch-this-year

 

Preliminary data from RSA is expected in the next few weeks and then onto trials in the UK if all goes well. "Covidity' has exciting aspects - it's administered 'needleless' and generates enhanced antibodies and long lasting T-cell immunity.

Edited January 3, 2022 by TorquayFan

[JerseytoBKK]

16 hours ago, TorquayFan said:

Scancell, the developer of 'Covidity', a 'universal' vaccine candidate against Covid virus, features among 6 'Companies to watch' in 2022 in 'The Observer' yesterday :-

 

"This spinout fom the University of Nottingham, founded in 1997 by Lindy Durrant, professor of cancer immunotherapy at the university, specialises in developing cancer vaccines and has started testing them on humans. But when the pandemic struck, the company decided to modify its vaccine technology to develop Covid shots, in collaboration with Nottingham’s two universities and backed by £2m funding from the UK’s innovation agency.

 

Check out Valneva. It's an old fashioned inactivated virus vaccine. Completed Phase 3 testing and supposedly better than AZ but seems some politics happened and the UK cancelled their contract. They recently announced a deal to supply EU countries pending approval.

 

Here is a list of 91 different vaccines that are under development: https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker.  That website is not 100% up to date but gives you an idea of the global effort underway.

[TorquayFan]

Thanks Jersey. With respect I think 'Valneva' vaccine although indeed very promising, is constructed to address a particular virus/ set of viruses and would not be considered a candidate as a 'Universal vaccine'.

 

In this 'Romanes' lecture, Kate Bingham, erstwhile Head of the UK's Vaccine Task Force, was scathing if not brutal about the Govt's handling of the Valneva project. I agree with her. Well worth a watch IMHO and it was a SAD day when she left that role ! https://youtu.be/tG_a0P2qybE

 

The market for Covid vaccines Worldwide is massive of course. There are many projects under way - let's hope that someone can come up with the goods ! https://cepi.net/news_cepi/going-universal-the-search-for-an-all-in-one-coronavirus-vaccine/

 

 

[TorquayFan]

To add to recent data about a potential 'Universal' covid vaccine. It's been widely observed in the last few days that we can't vaccinate the whole World every 4-6 months, so 2nd generation vaccines with longer lasting immunity, are much needed.

 

DNA vaccines may be part of the 2nd generation : "DNA vaccines come with other benefits. In trials so far, they appear to be very safe. “We haven’t really seen safety concerns,” says Horton. “Whereas with the other platforms that are out there—luckily the side effects are rare—but there are some safety issues with both the mRNA and the viral vector vaccines.” DNA vaccines are also highly stable and do not need the kind of expensive, low temperature storage the two mRNA vaccines require . . . ."

 

https://www.insideprecisionmedicine.com/topics/patient-care/therapeutics/vaccines/dna-vaccines-the-next-stage-in-the-vaccine-revolution/

 

Though not mentioned in this article, the Scancell 'Covidity' vaccine is a DNA vaccine, (developed from a DNA platform 'Immunobody' and a successful melanoma treatment in trial again now PLUS the 'Avidimab' enhancement of antibodies).

 

Whether it's 'Zydus' or Scancell that succeed - who cares. Preferably, BOTH and others will come through.

 

So is DNA the way forward against Covid ? We'll see.

 

 

Edited January 4, 2022 by TorquayFan

[TorquayFan]

Good 'ole Boris discusses the need for 'polyvalent' vaccines :-

 

"My right hon. Friend is totally right in what she says. We simply cannot go on, as a country and as a society, reaching endlessly for lockdown, which is the Opposition’s instinct, no matter what the cost and no matter what damage it does. We have to remain cautious, and I am afraid that I cannot tell the House that we can rule out absolutely everything to protect the public, but as I said to the country last night, I am confident—that is why I am repeating it today—that we can get through this wave of omicron with the balanced and proportionate approach that we are taking. I am glad to have my right hon. Friend’s support. For the future, we need the polyvalent vaccines that can deal with any type of covid mutation and variant, as well as the therapeutics, and that is what we are investing in as well . . . . "

 

IF ONLY, Kate Bingham (Dame) was still around . . . . . .

 

https://hansard.parliament.uk/Commons/2022-01-05/debates/22010526000001/Covid-19Update#contribution-C71BC0B6-949C-4D0B-9100-C0837DEF3AA6