Thailand Launches Major Dengue Vaccine Trial in Children

[snoop1130]

File photo for reference only

 

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

 

Endorsed by the National Communicable Disease Committee, this study seeks to evaluate the vaccine's effectiveness, with hopes of integrating it into Thailand's universal healthcare system upon completion. Director General of the Department of Disease Control, Dr Panumas Yanawetsakul, revealed that the testing is expected to conclude in three years, paving the way for the vaccine's inclusion in the healthcare programme.

 

Developed by a Japanese pharmaceutical company, the vaccine is a live-attenuated type, similar to the measles vaccine and already registered with the Thai FDA. Although promising, Dr Nakorn Premsri, leader of the National Vaccine Institute, cautions that its integration into the national healthcare scheme will require careful review, weighing the test results against cost-effectiveness.

 

 

While dengue vaccines are currently available in Thailand, they are primarily offered by private healthcare providers at significant cost. This government initiative aims to make dengue immunisation accessible and affordable to millions.

 

Endemic in over 100 countries, dengue fever remains a major health concern, especially in tropical areas like Thailand. The vaccine trial, therefore, is a critical effort to reduce infections and lessen the strain on the healthcare system. With Thailand reporting thousands of cases yearly, health experts are hopeful that a successful trial will lead to widespread immunisation, ultimately saving numerous lives.

 

The government is dedicated to monitoring the trial's progress and ensuring that, if successful, the vaccine quickly becomes part of public healthcare, reported The Thaiger.

 

-- 2025-03-14

 

 

[Stiddle Mump]

It's not in the 'off the beaten track' section. But I'll risk posting.

 

All I can say is; ''poor kids.''

[Lacessit]

11 minutes ago, Stiddle Mump said:

It's not in the 'off the beaten track' section. But I'll risk posting.

 

All I can say is; ''poor kids.''

Why worry? According to you, viruses don't exist.

[Stiddle Mump]

10 minutes ago, Lacessit said:

Why worry? According to you, viruses don't exist.

They don't; but those filthy jabs do.

 

The OP mentioned 'measles'. Just to point out that measles was fatal for 1 in 500,000, before the jab was introduced into the US. Pretty soon after, that ratio went to 1 in 10,000. Now it's even less. The UK's NHS say measles kills one in 100.

 

Hello!! Any white-coats listening?

[johng]

And no mention of "safety" precautions in the report above just money and that it "will save numerous lives" as if its a forgone conclusion.

They should be mindful of what has happened with live attenuated Polio vaccines. 

[Lacessit]

2 hours ago, Stiddle Mump said:

 

Hello!! Any white-coats listening?

They are probably coming for you.

[Lacessit]

2 hours ago, johng said:

And no mention of "safety" precautions in the report above just money and that it "will save numerous lives" as if its a forgone conclusion.

They should be mindful of what has happened with live attenuated Polio vaccines. 

Polio is still endemic in Afghanistan.

 

The country has one of the highest infant mortality rates in the world. Ignorant mullahs are mainly responsible for vaccine resistance.

 

The only notable  side effect I seem to have from my multiple vaccinations is a low tolerance of fools.

[connda]

3 hours ago, snoop1130 said:

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

...regardless of prior exposure to dengue?  You gotta be kidding?
That's irresponsible.  Antibody Dependent Enhancement affecting those who previously had Dengue are a dangerous and documented issue with of Dengue vaccines. It's also why as second infection of Dengue can kill you.  I hope they don't end up killing some of these children.  These kids need to be carefully screened prior to receiving the vaccine.  But it sounds like they are going to go "full speed ahead and damn the torpedoes."  So what if they kill some of the children of the peasant class.
Good lord.

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
"For the enhanced vaccine safety, all dengue vaccine candidates should be assessed for the extent of type-specific (minimal ADE) vs. cross-reactive (ADE promoting) neutralizing antibodies. The type-specific EDIII antibodies may be more directly related to protection from disease in the absence of ADE promoted by the cross-reactive antibodies."

https://pmc.ncbi.nlm.nih.gov/articles/PMC7642463/

[Stiddle Mump]

4 hours ago, snoop1130 said:

File photo for reference only

 

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

 

Endorsed by the National Communicable Disease Committee, this study seeks to evaluate the vaccine's effectiveness, with hopes of integrating it into Thailand's universal healthcare system upon completion. Director General of the Department of Disease Control, Dr Panumas Yanawetsakul, revealed that the testing is expected to conclude in three years, paving the way for the vaccine's inclusion in the healthcare programme.

 

Developed by a Japanese pharmaceutical company, the vaccine is a live-attenuated type, similar to the measles vaccine and already registered with the Thai FDA. Although promising, Dr Nakorn Premsri, leader of the National Vaccine Institute, cautions that its integration into the national healthcare scheme will require careful review, weighing the test results against cost-effectiveness.

 

 

While dengue vaccines are currently available in Thailand, they are primarily offered by private healthcare providers at significant cost. This government initiative aims to make dengue immunisation accessible and affordable to millions.

 

Endemic in over 100 countries, dengue fever remains a major health concern, especially in tropical areas like Thailand. The vaccine trial, therefore, is a critical effort to reduce infections and lessen the strain on the healthcare system. With Thailand reporting thousands of cases yearly, health experts are hopeful that a successful trial will lead to widespread immunisation, ultimately saving numerous lives.

 

The government is dedicated to monitoring the trial's progress and ensuring that, if successful, the vaccine quickly becomes part of public healthcare, reported The Thaiger.

 

-- 2025-03-14

 

 

I've no idea about the technicalities of the study. How many will get the real thing, and how many will receive a placebo. Will the kids past medical history be considered. Etc.

 

I think the outcome will be a lot of kids getting sick. And!! An outbreak of Dengue Fever in the province later this year. Just as the wet season gets underway. Then the call will go out; get the kids vaccinated.

[ronnie50]

The article didn't mention the brand - but clearly the study refers to the QDenga Vaccine marketed by a Japanese pharma. It's already approved by the Thai FDA as mentioned, and is also approved the European Medicines Agency - EMA (the EU's FDA) and other countries.

 

It's easily available at private hospitals here, so I don't think there's anything to worry about for the kids. It's approved for anyone 4 years of age and above by the EMA - no upper age limit for Europe. In Thailand they stick to 4 - 60 years of age. (The only reason 60 is the upper age limit is due to an abundance of caution recommended by the manufacturer as QDenga's trials didn't involve anyone older than that).

 

It's two shots/jabs spaced over 3 months. It isn't cheap though, as mentioned. So I'm not really sure what this Thai 'vaccine trial' is all about. How would reproducing the Qdenga Japanese trials on kids 7 - 10 make it any cheaper for Thailand? It seems an odd thing to do (unless they don't trust the original trials by the manufacturer). Regarding older people, the Japanese trials focused only on mere hundreds, compared to many thousands of younger kids, who are more vulnerable to dengue (by being outdoors more than older working-age people).

[connda]

1 hour ago, connda said:

...regardless of prior exposure to dengue?  You gotta be kidding?
That's irresponsible.  Antibody Dependent Enhancement affecting those who previously had Dengue are a dangerous and documented issue with of Dengue vaccines. It's also why as second infection of Dengue can kill you.  I hope they don't end up killing some of these children.  These kids need to be carefully screened prior to receiving the vaccine.  But it sounds like they are going to go "full speed ahead and damn the torpedoes."  So what if they kill some of the children of the peasant class.
Good lord.

Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
"For the enhanced vaccine safety, all dengue vaccine candidates should be assessed for the extent of type-specific (minimal ADE) vs. cross-reactive (ADE promoting) neutralizing antibodies. The type-specific EDIII antibodies may be more directly related to protection from disease in the absence of ADE promoted by the cross-reactive antibodies."

https://pmc.ncbi.nlm.nih.gov/articles/PMC7642463/

 

1 hour ago, ronnie50 said:

The article didn't mention the brand - but clearly the study refers to the QDenga Vaccine marketed by a Japanese pharma.

I've got it backwards.  If you've had Dengue that vaccine is recommended up to 60.  The ADE risk comes from vaccinating someone who never had Dengue and then contracts Dengue after the vaccination.  I looked into this a few years back and now remember that I was over the age limit but having had Dengue before, fit that checkbox.

Too bad they didn't provide the vaccine's name and manufacturer.  I'd be interested in knowing what it is.  Still - if they are vaccination all these kids without addressing ADE reactions - well, my humble opinion - it borders on criminal. No doubt the parents will be told it's 100% safe and to sign the liability waivers ("don't bother to read them") providing the researchers and vaccine manufacturer with indemnity.

Per QDenga:

[Dionigi]

14 hours ago, Stiddle Mump said:

They don't; but those filthy jabs do.

 

The OP mentioned 'measles'. Just to point out that measles was fatal for 1 in 500,000, before the jab was introduced into the US. Pretty soon after, that ratio went to 1 in 10,000. Now it's even less. The UK's NHS say measles kills one in 100.

 

Hello!! Any white-coats listening?

https://www.cdc.gov/measles/about/history.html

Of course this is the government lying to us, whereas some idiot on the internet can always be believed

[hotsun]

I had dengue before. I didnt know what it was when i had it, thought i was dying

[cdemundo]

14 hours ago, Stiddle Mump said:

They don't; but those filthy jabs do.

 

The OP mentioned 'measles'. Just to point out that measles was fatal for 1 in 500,000, before the jab was introduced into the US. Pretty soon after, that ratio went to 1 in 10,000. Now it's even less. The UK's NHS say measles kills one in 100.

 

Hello!! Any white-coats listening?

Doubling down on the claim that viruses don't exist?

Idiot or moron? Possibly a member of both groups?

[ChaiyaTH]

When you are no longer sleeping and you read headlines like 'doing a trial on kids' and that to be entirely regular news and normal. Well great they do this trial on kids, just not on my kid. Ciao. 

We all lived until today without it since humans exist so I guess we can also see trough the trials + 10 year later effects first then. No need to rush and get it yourself in that case at all.  It's unreal how many shots I am offered in Thailand for my son each time we visit (outside regular ones). 

They even offered a flu shot half a year ago, I looked at her as if she had lost her mind. Giving flu shots to healthy kids, wtf.

[Hamus Yaigh]

11 hours ago, Stiddle Mump said:

I've no idea about the technicalities of the study.

 

11 hours ago, Stiddle Mump said:

I think the outcome will be

 

You need to climb back into your conspiracy theory box you climbed out of pal.

[hotchilli]

17 hours ago, snoop1130 said:

Thailand is taking a significant step in combatting dengue fever by initiating a large-scale clinical trial for a new vaccine targeting children. Set to commence on April 4 in Nakhon Phanom province, the trial involves 35,000 children aged seven to ten, regardless of prior exposure to dengue.

Do the kids/parents/guardians have the right to say no way?

[Stiddle Mump]

1 hour ago, Dionigi said:

https://www.cdc.gov/measles/about/history.html

 

Of course this is the government lying to us, whereas some idiot on the internet can always be believed

The CDC has it wrong Mr Dionigi. I could say that they don't know what they are talking about, which would be bad enough. But IMO, they do. Big Pharma is firmly entrenched in these medical/health organisations. There is massive dosh to be earned for selling vaccines.

 

And Sir! You could do worse than read my musings. I know what I'm talking about.

 

If these white-coats really want to progress our Dengue knowledge, they would include placebo, blind and double blind parameters.

 

This is no trial. Not that i can see. Hope these white-coats responsible for this,  unscientific experiment, are reading this. And take notice.

 

IMO. It is all to push a Dengue vaccine.

[Stiddle Mump]

1 hour ago, Hamus Yaigh said:

You need to climb back into your conspiracy theory box you climbed out of pal.

Too much main stream TV for you Sir. BBC, CNN etc.

 

Do some research; why don't you?

[Stiddle Mump]

2 hours ago, cdemundo said:

Doubling down on the claim that viruses don't exist?

Idiot or moron? Possibly a member of both groups?

Truth stands on its own space. Don't need no secrecy. Don't need no embellishment. Can be open to any criticism. Can accept any questions.

 

As with a couple of others members here, too much MSM for you Sir. Do some research; why don't you?

[0ffshore360]

17 hours ago, Stiddle Mump said:

They don't; but those filthy jabs do.

 

The OP mentioned 'measles'. Just to point out that measles was fatal for 1 in 500,000, before the jab was introduced into the US. Pretty soon after, that ratio went to 1 in 10,000. Now it's even less. The UK's NHS say measles kills one in 100.

 

Hello!! Any white-coats listening?

The impact of measles is not all or nothing. Have you seen the aftermath of serious measles infections in children?

Hemorrhagic fever in children is no joke either.

[Captain Flack]

A troll post in all bold and changing a quote from English has been removed. @Adam Tomaszewski

[cdemundo]

1 hour ago, Stiddle Mump said:

Truth stands on its own space. Don't need no secrecy. Don't need no embellishment. Can be open to any criticism. Can accept any questions.

 

As with a couple of others members here, too much MSM for you Sir. Do some research; why don't you?

"Can accept any questions."

 

Ok, just one question.

You seriously do not believe that viruses exist?

[Stiddle Mump]

52 minutes ago, 0ffshore360 said:

The impact of measles is not all or nothing. Have you seen the aftermath of serious measles infections in children?

Hemorrhagic fever in children is no joke either.

As I say Sir. Before the measles jab was brought out in the US, a fatality was one o=in 500,000. Within a year of the jab roll out it was 1 in 10,000. Look it up; why don't you.

 

Of course the symptoms of measles can be horrific. I'm in no way suggesting otherwise. But when an outbreak occurs locally, as has been the case in Texas, I would look first at changes in the local environment for the reasons.

[Stiddle Mump]

54 minutes ago, cdemundo said:

"Can accept any questions."

 

Ok, just one question.

You seriously do not believe that viruses exist?

Good question Sir. Deserves an in-depth answer.

 

Prior to the discovery of electron microscophy in the 1930s, a 'virus' had never been seen. Since, it is now possible to show that they do. Or do they? When a cell decays, it not only breaks apart, but exudes 'new' minute particles. One such entity is an exosome. It is roughly the same size as other entities. It appears to have a particular function. That of aiding the easy removal of the dead cell.

 

Under an electron microsope there are many tiny particles. Some are indistinguishable from one and other. The virologists point to some of the cell fragments and say; 'that is a virus'. Not in my book though.

 

So why not simply isolate these elusive viruses and after characterizing them, find out of they cause illness? Here is perhaps the biggest stumbling block in the whole realm of virology. A virus - any virus - has never been isolated. Ever! And until a white-coat can find one, isolate one, characterize it, show it can replicate and cause disease, I say a pathogenic virus does not exist.

 

Under electron microsophy there are dozens of similarly shaped particles on each slide. And each slide is different. So, I'm not saying that one of the particles, distinct from the others, is not a virus. Until one is isolated it can be called anything. My gut feeling though, is that these tiny entities actually aid cell and tissue rejuvenation.

[cdemundo]

6 minutes ago, Stiddle Mump said:

Good question Sir. Deserves an in-depth answer.

 

Prior to the discovery of electron microscophy in the 1930s, a 'virus' had never been seen. Since, it is now possible to show that they do. Or do they? When a cell decays, it not only breaks apart, but exudes 'new' minute particles. One such entity is an exosome. It is roughly the same size as other entities. It appears to have a particular function. That of aiding the easy removal of the dead cell.

 

Under an electron microsope there are many tiny particles. Some are indistinguishable from one and other. The virologists point to some of the cell fragments and say; 'that is a virus'. Not in my book though.

 

So why not simply isolate these elusive viruses and after characterizing them, find out of they cause illness? Here is perhaps the biggest stumbling block in the whole realm of virology. A virus - any virus - has never been isolated. Ever! And until a white-coat can find one, isolate one, characterize it, show it can replicate and cause disease, I say a pathogenic virus does not exist.

 

Under electron microsophy there are dozens of similarly shaped particles on each slide. And each slide is different. So, I'm not saying that one of the particles, distinct from the others, is not a virus, Until one is isolated it can be called anything. My gut feeling though, is that these tiny entities actually aid cell and tissue rejuvenation.

Not true.

[Stiddle Mump]

16 minutes ago, cdemundo said:

Not true.

Wot!!?? All of the post?

 

Or just the bit you don't agree with!?

[cdemundo]

58 minutes ago, Stiddle Mump said:

Wot!!?? All of the post?

 

Or just the bit you don't agree with!?

Your conclusion is mainly based on your idea that viruses are identified by visual inspection of electron micrographs of viruses. Where you assert that cell fragments are misidentified as viruses.

 

This is not true.

Viruses are id using a variety of techniques:

Virus structures are identified and modeled using a combination of techniques, including:

Cryo-Electron Microscopy (cryo-EM): Allows researchers to visualize viruses in their native states at very high resolutions by rapidly freezing samples and imaging them with electron beams.

X-ray Crystallography: Involves crystallizing viral proteins and using X-ray diffraction to understand their atomic structure. This method requires highly pure and concentrated protein samples.

Nuclear Magnetic Resonance (NMR) Spectroscopy: Used for studying smaller viral proteins in solution, providing insights into their structure and dynamics.

Computational Modeling: This includes molecular dynamics simulations and homology modeling, which helps in predicting the three-dimensional structure of viral components based on known structures of similar proteins.

Mass Spectrometry: Can be used to analyze viral proteins and provide information about their size, structure, and modifications.

Genomic and Proteomic Analyses: Sequencing the virus genome and analyzing the expressed proteins can offer insights into the potential structure of virus components.

 

Enjoy your theorizing, I'm sure it provides you with hours of enjoyment.

But the idea (which you seem to waffle on a bit) that no viruses have been identified is not supportable.

[Stiddle Mump]

18 minutes ago, cdemundo said:

Your conclusion is mainly based on your idea that viruses are identified by visual inspection of electron micrographs of viruses. Where you assert that cell fragments are misidentified as viruses.

 

This is not true.

Viruses are id using a variety of techniques:

Virus structures are identified and modeled using a combination of techniques, including:

Cryo-Electron Microscopy (cryo-EM): Allows researchers to visualize viruses in their native states at very high resolutions by rapidly freezing samples and imaging them with electron beams.

X-ray Crystallography: Involves crystallizing viral proteins and using X-ray diffraction to understand their atomic structure. This method requires highly pure and concentrated protein samples.

Nuclear Magnetic Resonance (NMR) Spectroscopy: Used for studying smaller viral proteins in solution, providing insights into their structure and dynamics.

Computational Modeling: This includes molecular dynamics simulations and homology modeling, which helps in predicting the three-dimensional structure of viral components based on known structures of similar proteins.

Mass Spectrometry: Can be used to analyze viral proteins and provide information about their size, structure, and modifications.

Genomic and Proteomic Analyses: Sequencing the virus genome and analyzing the expressed proteins can offer insights into the potential structure of virus components.

 

Enjoy your theorizing, I'm sure it provides you with hours of enjoyment.

But the idea (which you seem to waffle on a bit) that no viruses have been identified is not supportable.

I'm aware of all your post's content.

 

No virus has ever been isolated. Any virus. Virologists have a bit of a problem here. Their idea of isolation is to grow something in a petri dish. As Enders did back in the 1950s. Nothing much has changed since. But! At last Enders did a control back then.

 

A pathogenic virus only exists in a computer orogramme. Not in the real world. But, as I say, there could be entities of a cell breakdown that are of unknown origin and referred to by some white-coats as viruses.

 

My own take is that viruses do not, in any way, cause illness.

 

There are basically only two reasons for sickness/illness**. First is when the body is not as efficient as it should be at defending/maintaining itself due to a deficiency. Secondly; poisons. Entities that are toxic to our bodies. These can be dealt with by a body in tip-tip shape, but if the body is not, then the toxic elements can cause havoc.

 

** What actually sickness/illness? Beyond the scope of this thread to answer that. 

[stevenl]

17 hours ago, Lacessit said:

Polio is still endemic in Afghanistan.

 

The country has one of the highest infant mortality rates in the world. Ignorant mullahs are mainly responsible for vaccine resistance.

 

The only notable  side effect I seem to have from my multiple vaccinations is a low tolerance of fools.

Science denying nutters. They're often driven by religion, like Afghanistan, Iran, bible belt.