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Sinovac says its COVID-19 vaccine more effective with longer dosing interval

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Sinovac says its COVID-19 vaccine more effective with longer dosing interval

 

2021-01-18T122559Z_1_LYNXMPEH0H0MM_RTROPTP_4_HEALTH-CORONAVIRUS-VACCINE-SINOVAC.JPG

FILE PHOTO: A nurse receives a dose of the Sinovac's coronavirus disease (COVID-19) vaccine, after Brazil health regulator Anvisa approved its emergency use at Hospital das Clinicas in Sao Paulo, Brazil January 17, 2021. REUTERS/Amanda Perobelli

 

BEIJING (Reuters) - China's Sinovac Biotech said on Monday that a clinical trial in Brazil showed its COVID-19 vaccine was almost 20 percentage points more effective in a small sub-group of patients who received their two doses longer apart.

 

The protection rate for 1,394 participants who received doses of either CoronaVac or placebo three weeks apart was nearly 70%, a Sinovac spokesman said.

 

Brazilian researchers announced last week that the vaccine's overall efficacy was 50.4% based on results from more than 9,000 volunteers, most of whom received doses 14 days apart, as outlined in the trial protocol.

 

The spokesman said a small number of participants received their second shot late due to a various reasons, without elaborating.

 

The dosing interval for COVID-19 vaccines has become a hot topic of debate among scientists, regulators and governments.

 

UK regulators have said a COVID-19 vaccine from AstraZeneca and Oxford University is more effective when there is a longer gap between doses than initially envisaged.

 

Britain has also decided to allow a longer gap between doses of a COVID-19 vaccine from Pfizer and BioNTech, even though the companies say they only have efficacy data for a shorter period between shots.

 

The Sinovac spokesman cautioned the robustness of the data from the sub-group was weaker than the 50% result, which is based on the combined data of those receiving doses two or three weeks apart.

 

While Sinovac's researchers had said early stage trials showed a four-week interval induced the stronger antibody response than two weeks, this is the first time the company has released efficacy data from a Phase III trial with dosing patterns that differ from its trial protocol.

 

Sinovac has yet to release global results of its Phase III trials, but its COVID-19 vaccine has been approved for emergency use in several countries, including Brazil, Indonesia and Turkey.

 

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-- © Copyright Reuters 2021-01-18
 
  • Popular Post
5 minutes ago, snoop1130 said:

China's Sinovac Biotech said on Monday that a clinical trial in Brazil showed its COVID-19 vaccine was almost 20 percentage points more effective in a small sub-group of patients who received their two doses longer apar

sales job

Fits in nicely with that other Thai recent report that they wanted to stretch time between shots to over a year to make their short supply go further

Even if true, 70% is still pretty sh...oddy compared with other vaccines.

 

  • Popular Post

They can put in a shiny red box , No Damn Way I take anything Chinese....

3 minutes ago, Ireland32 said:

They can put in a shiny red box , No Damn Way I take anything Chinese....

Yep. No damn way I buy ANYTHING Chinese!

so long as the time gap is between never and no way in hell, I'm all in for the Sinovax

16 hours ago, snoop1130 said:

The protection rate for 1,394 participants who received doses of either CoronaVac or placebo three weeks apart was nearly 70%, a Sinovac spokesman said.

So the placebo is just as effective???

If someone dies after the first Sinovac dose, do they count it as a success since there will certainly be a long interval until a second dose?

4 hours ago, Caldera said:

Even if true, 70% is still pretty sh...oddy compared with other vaccines.

 

70% is about what can be expected from a flu vaccine. I'mm believe ther other 90-95% efficacies when I see data from 100'sK people. The bigger the sample suze the better. Then there is the question of how long immunity lasts. 

The best vaccine is the one you can get, even if it's 50% effective, because if you still get sick you're much more likely to have a mild case, as your immune system will have a head start in fighting it.

Willing to bet, very few expats will take the Chinese Sinovac shot.  Bring in the Pfizer, please.

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