Avast also gets my vote.

Nice and clean interface. However it did fail in the past to catch a few major virus.

Also resource and CPU intensive even in the background. Avoid it on a slow machine (500Mhz or less) because it will take it down when browsing through your files.

Still a good choice.

Hi here's another suggestion for you, I use Zonealarm thats been mentioned here but I've gone for the Security Suite.

That gets you the firewall, antivirus, anti-spyware, email protection, an id lock (warns you if your pc sends your email address or passwords etc), oh and an instant messenger security.......thing .

Works out about £40.00 a year but I've had no problems with it and looking at the logs its been a busy bit of software, fixed 64 viruses and 5 spies.

As they say 'The choice is yours'

Bye

No antivirus software will give 100% protection.

Ive had stuff that AVG misses (downloaded on purpose to see)

I volunteer on a site that gets rid of virus and spyware so know how nasty these things can be.

My protection.

Antivirus:

AVG

ANTIVIR

(not normally wise to run 2 antivirus progs together but these work well together if configured correctly)

Non active (meaning you have to actively run it, as it doesnt run in the background. I use it once a week to make sure nothing has got past the other two):

A2 (or commonly called A squared)

OFF TOPIC BUT RELEVANT

Firewall:

Zonealarm

Anti spyware/adware:

SpywareGuard

Spybot S&D

AdAware SE

Spyware blaster

Best news is its all free!!!!

EDIT:

Keeping up with microsoft updates also reduces your chance of infection.