CureVac mRNA Vaccine Disappoints

[Pattaya Spotter]

CureVac Experimental Coronavirus Vaccine Just 47 Percent Effective

 

The results of the 40,000-person trial, announced in a news release Wednesday, mark a setback for a promising vaccine based on messenger RNA technology, the same approach at the core of the Pfizer-BioNTech and Moderna vaccines authorized late last year for use in the United States.

 

https://www.washingtonpost.com/health/2021/06/16/curevac-vaccine-how-effective/

 

[cormanr7]

Slightly off-topic, but Novavax has reported good results for their large scale trials (mainly conducted in US and Mexico) with efficacy -depending on variant- of up to 90%. https://www.nytimes.com/2021/06/14/health/covid-vaccine-novavax.html. It confirms earlier results from an UK trial  https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3

This one is interesting as it is neither an mRNA (BioNTech-Pfizer Curevac, Moderna, ), viral vector  (AZ, Janssen, Sputnik) or inactivated virus (Sinovac, Sinopharm) vaccine  but rather contains a full length spike protein. Presumably this S-protein is from the original sequence or an early variant.

There appear to be problems in large-scale production so won't be available before September at best. Can be kept at 2-8^oC.

And yes,  some of the names here refer to the manufacturer and others to the name of the vaccine, but this is how they are best known.

[Pattaya Spotter]

1 minute ago, cormanr7 said:

Slightly off-topic, but Novavax has reported good results for their large scale trials (mainly conducted in US and Mexico) with efficacy -depending on variant- of up to 90%. https://www.nytimes.com/2021/06/14/health/covid-vaccine-novavax.html. It confirms earlier results from an UK trial  https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3

This one is interesting as it is neither an mRNA (BioNTech-Pfizer Curevac, Moderna, ), viral vector  (AZ, Janssen, Sputnik) or inactivated virus (Sinovac, Sinopharm) vaccine  but rather contains a full length spike protein. Presumably this S-protein is from the original sequence or an early variant.

There appear to be problems in large-scale production so won't be available before September at best. Can be kept at 2-8^oC.

And yes,  some of the names here refer to the manufacturer and others to the name of the vaccine, but this is how they are best known.

Yes...good news and bad news.

[KhunBENQ]

6 hours ago, Pattaya Spotter said:

CureVac Experimental Coronavirus Vaccine Just 47 Percent Effective

Top news this morning in Germany.

Stocks dropped 50% or so.

Major setback for European vaccine campaign.

[Pattaya Spotter]

42 minutes ago, KhunBENQ said:

Top news this morning in Germany.

Stocks dropped 50% or so.

Major setback for European vaccine campaign.

Yes the EU pre-ordered 200-300M doses of this vaccine.

[cormanr7]

Major question of course is why the results were poor viz BioNTech-Pfizer and Moderna mRNA vaccines.

People tend to point to new variants as a reason but actually the afore mentioned mRNA vaccines seem to be relatively effective against those. The following article discusses some aspects of the Curevac approach based on what is publicly known (which is not that much):

https://www.livemint.com/companies/news/curevacs-covid-vaccine-setback-shows-not-all-mrna-jabs-are-equal-11623993200438.html

[Pattaya Spotter]

1 hour ago, cormanr7 said:

Major question of course is why the results were poor viz BioNTech-Pfizer and Moderna mRNA vaccines.

People tend to point to new variants as a reason but actually the afore mentioned mRNA vaccines seem to be relatively effective against those. The following article discusses some aspects of the Curevac approach based on what is publicly known (which is not that much):

https://www.livemint.com/companies/news/curevacs-covid-vaccine-setback-shows-not-all-mrna-jabs-are-equal-11623993200438.html

Though they are all mRNA based vaccines, there are significant differences between the methodology of the  CureVac te and Moderna/BioNtec vaccines. I'm no expert but it's set forth in most.of the stories of the failure.