Mahidol University: Dengue fever vaccine expected in five years

[webfact]

Vaccine expected in five years
Poungchompoo Prasert
The Nation



BANGKOK: -- THAI researchers expect a vaccine for all strains of dengue haemorrhagic fever will be available in the next five years.

Suthee Yoksan, director of Centre for Vaccine Development at Mahidol University's Institute of Molecular Bio-sciences, reported yesterday on the progress of a vaccine for dengue, which it has been working on since 2009.

Suthee said Thailand had no industrial production capacity so the right to make this live attenuated vaccine was granted to a company in Japan. Vaccine tests on monkeys had yielded a good result - 100 per cent immunisation against all dengue strains via one shot. Immunity occurred 14 to 28 days after vaccination and could last for up to five to 10 years, he said.

The vaccine would be tested on humans from next year, in three phases, he said. The first phase would be a test on 20-50 subjects in Australia, which would take one year. The second phase would be a test on 100-400 subjects in Thailand, which would take two years. The third phase, also in Thailand, would be carried out on over 5,000 people and take three years. So, the vaccine could be complete and ready for use in five years, he said.

Source: http://www.nationmultimedia.com/national/Vaccine-expected-in-five-years-30273184.html


-- The Nation 2015-11-18

[webfact]

Doctors call for more funds to find cure for dengue fever
The Nation

BANGKOK: -- THE GOVERNMENT should fund research and human-resource development to combat dengue haemorrhagic fever (DHF), an expert told a recent seminar.

"Efforts in this area will need from Bt200 million to Bt300 million [to be effective]," said Prof Dr Sukathida Ubol.

This year, DHF has already infected over 100,000 people and caused more than 100 deaths in Thailand. To date, no vaccine can counter the disease and available medicines can only help patients based on palliative care [to relieve the symptoms].

Speaking at the seminar at Mahidol University's Faculty of Science, Sukathida said funding would encourage the development of a vaccine and treatment for DHF.

She said the Thailand Research Fund and the National Vaccine Institute have supported a project to develop nasal-spray vaccines to protect against type-three-DHF, which is the hardest to cure.

"We are developing the vaccine as a nasal-spray, the easiest form to use with children," said Sukathida, who teaches microbiology at the Mahidol University and has taken part in the project.

Sukathida said people exposed to dengue for a second time with a different genus would face infections 15 to 80 times more severe than normal dengue.

She said 0.2 to 2 per cent of mosquitoes in Thailand carried the dengue virus, which can be transferred to their offspring by reproduction.

She said the main symptom in severe dengue was a decrease in the immune system, where white blood cell numbers could fall by 100 to 1,000 times, following a rise in the number of viruses. The virus harms blood platelets and blood vessels and could result in bleeding or even shock to the patient.

Sukathida also expressed concern about blood donations in Thailand, which are often not tested for dengue. Infected people could unknowingly donate dengue-tainted blood.

As Thailand doesn't have any anti-virals for DHF treatment and people tend to know they're ill only a short time after infection, doctors only have a couple of days to cure them, which is not enough. The best solution, said Sukathida, would be an injected vaccine to create immunity.

The possibility of an outbreak became a big issue after well-known actor Tridsadee "Por" Sahawong was admitted to a hospital with a critical case of dengue fever.

Dr Arunee Thitithanyanont, an expert on the immune system and blood diseases, said blood platelet counts in infected people fall, causing them to bleed easily.

If they take painkiller pills, they could damage their stomachs, leading to more bleeding or shock.

The symptoms are high fever for two to three days, and pain in the eye sockets, bones and muscles. She urged people with those symptoms to immediately see a doctor.

Source: http://www.nationmultimedia.com/national/Doctors-call-for-more-funds-to-find-cure-for-dengu-30273186.html


-- The Nation 2015-11-18

[starky]

Magic another massive milestone for Thai medicine. Is there nothing they can not cure?

[rkidlad]

Can they also do Ebola and aids while they're at it?

[Seastallion]

Can they also do Ebola and aids while they're at it?

Done and dusted, I thought.

[Seastallion]

"......... Immunity occurred 14 to 28 days after vaccination and could last for up to five to 10 years, he said."

How can you know it lasts ten years if you've only been testing it for a few years?

[Seastallion]

So, lab-testing to be done in Japan and first field trials in Australia.

It sounds as though Thailand's only contribution will be the larger field test after Australia. It sounds as though some, if not all, the scientific brains behind the project are not in Thailand and Mahidol is just a junior partner in the project.

[LannaGuy]

same bunch who announced cure for Ebola?

[dcpo]

You guys laugh but the medicine school at Mahidol does very good research. They even have a long running collaboration with Oxford University. If you want to study tropical diseases then Mahidol is one of the best places to go.

[sanukjim]

Is this not the is the same Thai University that had found a cure for Ebola when the W.H.O. could not ? Also weren't they close to eradicating HIV a while back ? Oh yes you sure want to be on their list of patient experiments.

[thesetat2013]

Is this not the is the same Thai University that had found a cure for Ebola when the W.H.O. could not ? Also weren't they close to eradicating HIV a while back ? Oh yes you sure want to be on their list of patient experiments.

Agreed. I know I would not want to one of their test subjects for this.

Also, didn't this school find the cure for cancer as well as all the others mentioned here? All, of course, without world acknowledgement.

[The Deerhunter]

Can they also do Ebola and aids while they're at it?

Done and dusted, I thought.

And was it their engineering department that also invented the internet, cold fusion and the aeroplane?

It makes you cringe in embarrassment, doesn't it, for all the nice Thai people you know.

Edited November 18, 2015 by The Deerhunter

[TallGuyJohninBKK]

Magic another massive milestone for Thai medicine. Is there nothing they can not cure?

But the actual production of any trial vaccine has to be outsourced to Japan because Thailand doesn't have the production capacity (which is what the OP reports)???

Suthee said Thailand had no industrial production capacity so the right to make this live attenuated vaccine was granted to a company in Japan.

Edited November 18, 2015 by TallGuyJohninBKK

[petedk]

This is obviously a serious issue and I hope they find an effective vaccine soon.

I have two friends who have had Dengue fever and sadly one of them died.

What amazes me most is the fact that this probably wouldn't have been news if it wasn't because of the Thai actor Por who is seriously ill with Dengue.

[american12bthai]

Doctors call for more funds to find cure for dengue fever

The Nation

BANGKOK: -- THE GOVERNMENT should fund research and human-resource development to combat dengue haemorrhagic fever (DHF), an expert told a recent seminar.

"Efforts in this area will need from Bt200 million to Bt300 million [to be effective]," said Prof Dr Sukathida Ubol.

This year, DHF has already infected over 100,000 people and caused more than 100 deaths in Thailand. To date, no vaccine can counter the disease and available medicines can only help patients based on palliative care [to relieve the symptoms].

Speaking at the seminar at Mahidol University's Faculty of Science, Sukathida said funding would encourage the development of a vaccine and treatment for DHF.

She said the Thailand Research Fund and the National Vaccine Institute have supported a project to develop nasal-spray vaccines to protect against type-three-DHF, which is the hardest to cure.

"We are developing the vaccine as a nasal-spray, the easiest form to use with children," said Sukathida, who teaches microbiology at the Mahidol University and has taken part in the project.

Sukathida said people exposed to dengue for a second time with a different genus would face infections 15 to 80 times more severe than normal dengue.

She said 0.2 to 2 per cent of mosquitoes in Thailand carried the dengue virus, which can be transferred to their offspring by reproduction.

She said the main symptom in severe dengue was a decrease in the immune system, where white blood cell numbers could fall by 100 to 1,000 times, following a rise in the number of viruses. The virus harms blood platelets and blood vessels and could result in bleeding or even shock to the patient.

Sukathida also expressed concern about blood donations in Thailand, which are often not tested for dengue. Infected people could unknowingly donate dengue-tainted blood.

As Thailand doesn't have any anti-virals for DHF treatment and people tend to know they're ill only a short time after infection, doctors only have a couple of days to cure them, which is not enough. The best solution, said Sukathida, would be an injected vaccine to create immunity.

The possibility of an outbreak became a big issue after well-known actor Tridsadee "Por" Sahawong was admitted to a hospital with a critical case of dengue fever.

Dr Arunee Thitithanyanont, an expert on the immune system and blood diseases, said blood platelet counts in infected people fall, causing them to bleed easily.

If they take painkiller pills, they could damage their stomachs, leading to more bleeding or shock.

The symptoms are high fever for two to three days, and pain in the eye sockets, bones and muscles. She urged people with those symptoms to immediately see a doctor.

Source: http://www.nationmultimedia.com/national/Doctors-call-for-more-funds-to-find-cure-for-dengu-30273186.html

-- The Nation 2015-11-18

thats strange, many place have cures/treatment. Dengue is a BIG problem on hawaii. but guess what ,,,,, they have what your "scientist" are looking for. and thai scientist are not going to be happy cauese its a verrrrry common tree here in thailand. so i have no idea as to why they cant figure out something you can easily GOOGLE IT. oh wait, thais only know fb.

Edited November 18, 2015 by american12bthai

[lujanit]

Suthee Yoksan, director of Centre for Vaccine Development at Mahidol University's Institute of Molecular Bio-sciences, reported yesterday on the progress of a vaccine for dengue, which it has been working on since 2009.

Immunity occurred 14 to 28 days after vaccination and could last for up to five to 10 years, he said.

Show me the peer reviewed paper published in a reputable journal that says 'could last for five to ten years' and I might think there is something behind the claim.

[Srikcir]

"the vaccine could be complete and ready for use in five years"

The stated timeline for testing follows:

Phase 1 - 1 year

Phase 2 - 2 years

Phase 3 - 3 years.........that's a total of six years

But even after Phase 3 the vaccine cannot be marketed in Thailand until it receives FDA approval of a New Drug Application (NDA). That approval process can take up to two more years. That makes the total timeline potentially as long as eight years. And that presumes the vaccine passes all the clinical trials according to the projected timelines.

[EnglishJohn]

I remember that the same Thai university claimed they had a vaccine for Ebola.

Then it all went quiet. Whatever happened to that ?. I just did a search and nothing about Thailand came up. A place in Canada found it.

Are they really using the same trick again ?.

Thailand : land of lies.

[sean in udon]

Looks like the Mahidol University might be playing catch up:

http://m.ocregister.com/articles/vaccine-695418-dengue-mexico.html

Google 'sanofi pasteur dengue vaccine 2015' and there's loads of info about it.

[Thian]

Doctors call for more funds to find cure for dengue fever

The Nation

BANGKOK: -- THE GOVERNMENT should fund research and human-resource development to combat dengue haemorrhagic fever (DHF), an expert told a recent seminar.

"Efforts in this area will need from Bt200 million to Bt300 million [to be effective]," said Prof Dr Sukathida Ubol.

This year, DHF has already infected over 100,000 people and caused more than 100 deaths in Thailand. To date, no vaccine can counter the disease and available medicines can only help patients based on palliative care [to relieve the symptoms].

Speaking at the seminar at Mahidol University's Faculty of Science, Sukathida said funding would encourage the development of a vaccine and treatment for DHF.

She said the Thailand Research Fund and the National Vaccine Institute have supported a project to develop nasal-spray vaccines to protect against type-three-DHF, which is the hardest to cure.

"We are developing the vaccine as a nasal-spray, the easiest form to use with children," said Sukathida, who teaches microbiology at the Mahidol University and has taken part in the project.

Sukathida said people exposed to dengue for a second time with a different genus would face infections 15 to 80 times more severe than normal dengue.

She said 0.2 to 2 per cent of mosquitoes in Thailand carried the dengue virus, which can be transferred to their offspring by reproduction.

She said the main symptom in severe dengue was a decrease in the immune system, where white blood cell numbers could fall by 100 to 1,000 times, following a rise in the number of viruses. The virus harms blood platelets and blood vessels and could result in bleeding or even shock to the patient.

Sukathida also expressed concern about blood donations in Thailand, which are often not tested for dengue. Infected people could unknowingly donate dengue-tainted blood.

As Thailand doesn't have any anti-virals for DHF treatment and people tend to know they're ill only a short time after infection, doctors only have a couple of days to cure them, which is not enough. The best solution, said Sukathida, would be an injected vaccine to create immunity.

The possibility of an outbreak became a big issue after well-known actor Tridsadee "Por" Sahawong was admitted to a hospital with a critical case of dengue fever.

Dr Arunee Thitithanyanont, an expert on the immune system and blood diseases, said blood platelet counts in infected people fall, causing them to bleed easily.

If they take painkiller pills, they could damage their stomachs, leading to more bleeding or shock.

The symptoms are high fever for two to three days, and pain in the eye sockets, bones and muscles. She urged people with those symptoms to immediately see a doctor.

Source: http://www.nationmultimedia.com/national/Doctors-call-for-more-funds-to-find-cure-for-dengu-30273186.html

-- The Nation 2015-11-18

thats strange, many place have cures/treatment. Dengue is a BIG problem on hawaii. but guess what ,,,,, they have what your "scientist" are looking for. and thai scientist are not going to be happy cauese its a verrrrry common tree here in thailand. so i have no idea as to why they cant figure out something you can easily GOOGLE IT. oh wait, thais only know fb.

Papaya helps against dengue plus also a tiny plant which is a weed in my garden...don't know the name.

[bangrak]

Can't say on which Farang TV news channel it was (TV5 Monde?) this morning that a vaccine against Dengue fever had been tested out, in Europe..., and was soon going to be produced by Sanofi (in 3 injections, not for children, only for people living in infested areas)...

Could there be a link with this annoucement by Mahidol? That they are well aware of this news and attempt to pull to themselves the little bit of the rug which might be left, not to become at once 'redundant', after 6 years of research, and spent investments, but still not having started human testing, far from ready to enter the test production phase in a lab, not even speaking of an industrial phase?

Vaccines are multi Billions of US$ businesses, one of the most profitable of the pharmaceutical industry, so it's a permanent race for research labs, and like in all races, there are winners, and...

[Thian]

Seriously, what happened to the Thai vaccin against Ebola? Was it really working or not? Last thing i heard about it was that the USA was going to test it.

[apetley]

Is this not the is the same Thai University that had found a cure for Ebola when the W.H.O. could not ? Also weren't they close to eradicating HIV a while back ? Oh yes you sure want to be on their list of patient experiments.

Here's an article on their claim of a cure.

http://www.establishmentpost.com/thailand-announces-cure-vaccine-for-ebola/

Edited December 10, 2015 by apetley

[bangrak]

"the vaccine could be complete and ready for use in five years"

The stated timeline for testing follows:

Phase 1 - 1 year

Phase 2 - 2 years

Phase 3 - 3 years.........that's a total of six years

But even after Phase 3 the vaccine cannot be marketed in Thailand until it receives FDA approval of a New Drug Application (NDA). That approval process can take up to two more years. That makes the total timeline potentially as long as eight years. And that presumes the vaccine passes all the clinical trials according to the projected timelines.

Let's hope then that any other vaccine coming on the (world) market, after undergoing all possible international tests, way before the Thai one (eventually) does, will not be blocked or braked off by the local FDA administration for the usual bad reasons of face and greed, or made so very expensive locals can't afford it...

[Usernames]

Mahidol seems to be a day late and a dollar short.

[DM07]

"......... Immunity occurred 14 to 28 days after vaccination and could last for up to five to 10 years, he said."

How can you know it lasts ten years if you've only been testing it for a few years?

Time -like electricity- works differently in Thailand!

[jacky54]

Just seen on Aljazera that they already developed a vaccine in S America

[dru2]

Can't say on which Farang TV news channel it was (TV5 Monde?) this morning that a vaccine against Dengue fever had been tested out, in Europe..., and was soon going to be produced by Sanofi (in 3 injections, not for children, only for people living in infested areas)...

Could there be a link with this annoucement by Mahidol? That they are well aware of this news and attempt to pull to themselves the little bit of the rug which might be left, not to become at once 'redundant', after 6 years of research, and spent investments, but still not having started human testing, far from ready to enter the test production phase in a lab, not even speaking of an industrial phase?

Vaccines are multi Billions of US$ businesses, one of the most profitable of the pharmaceutical industry, so it's a permanent race for research labs, and like in all races, there are winners, and...

French vaccine developed jointly with Mexico.... Pipped the Thais to the post and prompted this rather sad response from Mahidol. Al-Jazeera has been running quite a long news story about it.

[cooked]

Doctors call for more funds to find cure for dengue fever

The Nation

BANGKOK: -- THE GOVERNMENT should fund research and human-resource development to combat dengue haemorrhagic fever (DHF), an expert told a recent seminar.

"Efforts in this area will need from Bt200 million to Bt300 million [to be effective]," said Prof Dr Sukathida Ubol.

This year, DHF has already infected over 100,000 people and caused more than 100 deaths in Thailand. To date, no vaccine can counter the disease and available medicines can only help patients based on palliative care [to relieve the symptoms].

Speaking at the seminar at Mahidol University's Faculty of Science, Sukathida said funding would encourage the development of a vaccine and treatment for DHF.

She said the Thailand Research Fund and the National Vaccine Institute have supported a project to develop nasal-spray vaccines to protect against type-three-DHF, which is the hardest to cure.

"We are developing the vaccine as a nasal-spray, the easiest form to use with children," said Sukathida, who teaches microbiology at the Mahidol University and has taken part in the project.

Sukathida said people exposed to dengue for a second time with a different genus would face infections 15 to 80 times more severe than normal dengue.

She said 0.2 to 2 per cent of mosquitoes in Thailand carried the dengue virus, which can be transferred to their offspring by reproduction.

She said the main symptom in severe dengue was a decrease in the immune system, where white blood cell numbers could fall by 100 to 1,000 times, following a rise in the number of viruses. The virus harms blood platelets and blood vessels and could result in bleeding or even shock to the patient.

Sukathida also expressed concern about blood donations in Thailand, which are often not tested for dengue. Infected people could unknowingly donate dengue-tainted blood.

As Thailand doesn't have any anti-virals for DHF treatment and people tend to know they're ill only a short time after infection, doctors only have a couple of days to cure them, which is not enough. The best solution, said Sukathida, would be an injected vaccine to create immunity.

The possibility of an outbreak became a big issue after well-known actor Tridsadee "Por" Sahawong was admitted to a hospital with a critical case of dengue fever.

Dr Arunee Thitithanyanont, an expert on the immune system and blood diseases, said blood platelet counts in infected people fall, causing them to bleed easily.

If they take painkiller pills, they could damage their stomachs, leading to more bleeding or shock.

The symptoms are high fever for two to three days, and pain in the eye sockets, bones and muscles. She urged people with those symptoms to immediately see a doctor.

Source: http://www.nationmultimedia.com/national/Doctors-call-for-more-funds-to-find-cure-for-dengu-30273186.html

-- The Nation 2015-11-18

thats strange, many place have cures/treatment. Dengue is a BIG problem on hawaii. but guess what ,,,,, they have what your "scientist" are looking for. and thai scientist are not going to be happy cauese its a verrrrry common tree here in thailand. so i have no idea as to why they cant figure out something you can easily GOOGLE IT. oh wait, thais only know fb.

So you're claiming that Dengue can strangely be prevented by using this miraculous tree? How silly of us.

Or maybe you mean treated with.

[Usernames]

A culture without a sense of urgency sees the other players whip past them to the finish line.