Anyone know which roads are closed and how long diversions take ? It looks like they have blocked the main route ?

'Road blocks set up by protesters were making it difficult for local people and tourist alike to travel in the South. With the main routes to the Andaman Islands obstructed the damage done to regional tourism is inestimable, he said.'

http://www.samuitimes.com/tcc-protests-hurting-south-economy/

Already reported :

http://www.thaivisa.com/forum/topic/650209-interesting-topics-reads/page-2#entry6790216

http://www.thaivisa.com/forum/topic/650209-interesting-topics-reads/page-2#entry6791268

If driving to Bangkok you can take the detour & bypass the protesters. Just drive Straight past Central on that road & turn right before the major highway & that will link you.