Gene Variant Most Prevalent in Asian-Descent Populations Doubles Risk of Respiratory Failure from COVID-19

[Atlantis]

https://www.clinicalomics.com/topics/patient-care/coronavirus/gene-variant-most-prevalent-in-asian-descent-populations-doubles-risk-of-respiratory-failure-from-covid-19/

 

Scientists at Oxford University have found evidence that variation in a single gene, LZTFL1, doubles the risk of respiratory failure from COVID-19. Sixty percent of people with South Asian ancestry carry a genetic signal for this effect, partly explaining the excess deaths seen in some U.K. communities, and the impact of COVID-19 in the Indian subcontinent.

 

The study was published in Nature Genetics, by a team lead by Professors James Davies and Jim Hughes at the University of Oxford’s MRC Weatherall Institute of Molecular Medicine. Previous work has identified a stretch of DNA on chromosome 3, the 3p21.31 region, which doubles the risk of adults under 65 of dying from COVID.

 

 

https://www.nature.com/articles/s41588-021-00955-3

 

Alternative sources, analysis / commentary:

https://fit.thequint.com/coronavirus/gene-ethnicity-covid-hospitalisation-and-death-risk
https://www.aljazeera.com/features/2021/11/17/could-this-gene-double-your-risk-of-dying-from-covid-19
https://www.revyuh.com/news/lifestyle/health-and-fitness/a-gene-variation-that-doubles-the-risk-of-dying-of-covid-19/

https://www.eatthis.com/news-lztfl1-gene-covid-death-risk/

[Danderman123]

Unfortunately, genetics is in its infancy, so such studies are often contradictory.

 

https://www.nature.com/articles/s41586-020-2818-3

 

 

[Atlantis]

1 hour ago, Danderman123 said:

Unfortunately, genetics is in its infancy, so such studies are often contradictory.

 

https://www.nature.com/articles/s41586-020-2818-3

 

 

"My one is newer than your one!" And obviously bigger and shinier.

Besides, your link supports the study above , if that is what you meant to say.

In terms of carrier frequencies, we find that 50% of people in South Asia carry at least one copy of the risk haplotype, whereas 16% of people in Europe and 9% of admixed American individuals carry at least one copy of the risk haplotype. The highest carrier frequency occurs in Bangladesh, where more than half the population (63%) carries at least one copy of the Neanderthal risk haplotype.

[Danderman123]

25 minutes ago, Atlantis said:

"My one is newer than your one!" And obviously bigger and shinier.

Besides, your link supports the study above , if that is what you meant to say.

In terms of carrier frequencies, we find that 50% of people in South Asia carry at least one copy of the risk haplotype, whereas 16% of people in Europe and 9% of admixed American individuals carry at least one copy of the risk haplotype. The highest carrier frequency occurs in Bangladesh, where more than half the population (63%) carries at least one copy of the Neanderthal risk haplotype.

Oops, I posted the wrong study:

 

https://www.pnas.org/content/118/9/e2026309118