Us Visitor Visa Entry

A while back the girlfriend got a new 2 entry visitor visa. Both entries have a different, specific US location on them that was based on our original itinerary. Now our plans for the second entry have changed.

1) Will we have a problem entering the US at a different port and heading to a different city than listed for the second entry? We would be spending no time in the city listed for the entry during the entire visit.

2) If we did enter and go to a different location, would this be recorded in the system and affect our chances for future visa applications as it would look like we lied?

I would hate to have to pay another visa fee and waste all the time just to get the entry location changed because of a basic change of itinerary.