Three COVID-19 Vaccines Developed in Thailand Are in Human Trials

[webfact]

 

By Subhabhong Rarueysong

   

BANGKOK (NNT) - The National Research Council of Thailand and National Vaccine Institute have revealed that more than 20 COVID-19 vaccines are being researched and developed in Thailand, while three candidates are undergoing human trials.

 

ChulaCov19, an mRNA vaccine developed by Chulalongkorn University, is in the first phase of human trials on 72 volunteers. Two doses of the vaccine were given at an interval of 21 days.

 

The second one is HXP-GPOVac, an inactivated virus vaccine, jointly developed by the Faculty of Tropical Medicine at Mahidol University and the Government Pharmaceutical Organization. It is in the second phase of human trials in 460 volunteers. Two doses of the vaccine were injected at an interval of 28 days.

 

The third vaccine is Covigen, a DNA vaccine developed by Bionet Asia and Technovalia, which has started its first phase of human trials in 150 volunteers. Two doses of the vaccine were injected at an interval of 28 days.

 

-- © Copyright NNT 2021-07-06

 

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[ezzra]

All i can say is my condolences for the families of those "human"... That how much faith i put in a Thai developed vaccine...

Edited July 6, 2021 by ezzra

[brommers]

Woo hoo! So only another year before the first trickle of supplies. I bet that few people will want to risk these.

[sawadee1947]

This is the first step followed by phase 1,2 and 3.

Given the vaccine works and given the outcome will be a protection of more than 95%..........when will it be on the market? 

2022 or 2023?

And if you think of all imvested money it might have been wiser to buy, not order only, Biontech and Moderna in time. 

However, I have my doubts that soldiers would think that much. ????

[Justgrazing]

3 hours ago, webfact said:

The second one is HXP-GPOVac,

 

Sounds like a souped up vacuum cleaner with a name like that ...

[Boedog]

Anyone who has got a vaccine is involved in Human trails don't kid yourself and think your not

[mrfill]

Rather like the games console I once saw for sale as a Sony Polystation, I expect these to be renamed Thaiovac, Thaizer and Thaidena quite soon

[mackayae]

"ChulaCov19 was designed and developed by a team of Thai researchers working collaboratively with Pennsylvania University’s Professor Drew Weissman a physician-scientist renowned for his discovery of the technology used in the production of this vaccine."

[Denim]

28 minutes ago, mrfill said:

Rather like the games console I once saw for sale as a Sony Polystation, I expect these to be renamed Thaiovac, Thaizer and Thaidena quite soon

 

After the trials the results looked promising although reported side effects were a tendency to ' mince ' rather than walk and to hold one arm out with the hand turned down at the wrist.

[riparian]

44 minutes ago, mackayae said:

"ChulaCov19 was designed and developed by a team of Thai researchers working collaboratively with Pennsylvania University’s Professor Drew Weissman a physician-scientist renowned for his discovery of the technology used in the production of this vaccine."

 

Yes they seem to claiming credit where credit is not due.  HXP-GPOVac has also been developed elsewhere and I posted about it on another thread a few days ago.

 

[Peterphuket]

Unbelievable, normally it takes 5 years before they can bring a vaccine can be marketed.

Anyone interested?

Definitely not for me.

[richard_smith237]

14 minutes ago, Peterphuket said:

Unbelievable, normally it takes 5 years before they can bring a vaccine can be marketed.

Anyone interested?

Definitely not for me.

 

There is nothing normal about the current situation, more money, more attention has been thrown at the vaccines.

The system is realising a degree efficiency otherwise removed by the human factor, documents are not sat on a bureaucrats desk for months or even years on end. Patents are being approved more readily.

 

It could be argued the only ’short cut’ is phase 3. 

 

In addition to this much of the tech and ingredients are well established and known. 

 

 

Comparing anything that happens now with vaccine approval to a ’normal’ timeline simply highlights a lack of understanding of what slowed down the approvals in the first place. 

 

 

 

 

 

 

 

[placeholder]

4 hours ago, richard_smith237 said:

 

There is nothing normal about the current situation, more money, more attention has been thrown at the vaccines.

The system is realising a degree efficiency otherwise removed by the human factor, documents are not sat on a bureaucrats desk for months or even years on end. Patents are being approved more readily.

 

It could be argued the only ’short cut’ is phase 3. 

 

In addition to this much of the tech and ingredients are well established and known. 

 

 

Comparing anything that happens now with vaccine approval to a ’normal’ timeline simply highlights a lack of understanding of what slowed down the approvals in the first place. 

Also, an mRNA vaccine can be broken down into 2 parts. One part is the specific RNA molecule, and the other is everything, which is colloquially known as the launching pad. Once that is established to be safe, only the RNA is different.  It's a modular system.

Whereas in the case of old fashioned vaccines, each time one was tested it was a custom job. So everything had to tested.

And of course, biological technology has advanced extraordinarily quickly. It took just a few weeks for a full model of the structure of the covid19 virus to be developed and analyzed. That would have been the work of years not so long ago. Or even impossible to have been done.

[cdemundo]

5 hours ago, richard_smith237 said:

 

There is nothing normal about the current situation, more money, more attention has been thrown at the vaccines.

The system is realising a degree efficiency otherwise removed by the human factor, documents are not sat on a bureaucrats desk for months or even years on end. Patents are being approved more readily.

 

It could be argued the only ’short cut’ is phase 3. 

 

In addition to this much of the tech and ingredients are well established and known. 

 

 

Comparing anything that happens now with vaccine approval to a ’normal’ timeline simply highlights a lack of understanding of what slowed down the approvals in the first place. 

 

 

 

 

 

 

 

Above and beyond the expediting of bureaucratic approvals, a big difference was no waiting for financing.  In the past each phase had to wait on the results of the previous phase to be analyzed in order to get financing for the next phase.  As well as being safe and effective it had to be perceived as marketable. Financing was essentially guaranteed by the worldwide demand and so that delay was eliminated.

 

[mtls2005]

For a splash of reality, assuming one of these candidates makes it through, volume production might be available on two years, best case.

 

Just in time for COVID-23, with a vaccine targeted at COVID-19.

 

 

[friendofthai]

2 hours ago, mtls2005 said:

For a splash of reality, assuming one of these candidates makes it through, volume production might be available on two years, best case.

 

Just in time for COVID-23, with a vaccine targeted at COVID-19.

Yes, but local production means independence and freedom. Thai people will not have to make humiliating concessions to other countries in order to get vaccines.

[placeholder]

24 minutes ago, friendofthai said:

Yes, but local production means independence and freedom. Thai people will not have to make humiliating concessions to other countries in order to get vaccines.

You mean like giving priority to Chinese citizens resident in Thailand in exchange for a donation of vaccines?

[Thomas J]

Actually to be correct, all of the vaccines being administered are currently involved in human trials.  There is no long term human clinical study to ascertain the effectiveness and long term effects of any of the vaccines.  We are the human trial.