Another Clinical Trial Finds No Evidence to Support the Use of Ivermectin

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This is a peer-reviewed study appearing in the Journal of the American Medical Association. 

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.

 Conclusion and Relevance: Among adults with mild COVID-19, a 5-day course of ivermectin, compared with placebo, did not significantly improve the time to resolution of symptoms. The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand the effects of ivermectin on other clinically relevant outcomes.

https://plus.mcmaster.ca/COVID-19/Article/Details/33662102

[Scott]

We do know that it has never been the 'miracle' drug for Covid that it was touted to be.  

[onthedarkside]

A post citing a nearly year-old 2021 summary recycling some past research findings on ivermectin -- in which the journal where it was published has posted a public notice noting questions about the accuracy of data included in some of prior research reviewed -- has been removed.

 

The most current and reputable research on the use of ivermectin as a potential treatment for COVID is the following RCT study reported last month:

 

Ivermectin futile for mild to moderate COVID-19, study finds

 

"Early treatment with the antiparasitic drug ivermectin does not lower the risk of severe disease when given to patients with mild to moderate COVID-19, according to a study today in JAMA Internal Medicine.

...

Doctors at 20 Malaysian government hospitals and a COVID-19 quarantine center conducted an open-label, randomized clinical trial on the use of ivermectin in the first week of COVID-19 symptom onset in hospitalized adults 50 years and older with mild or moderate illness and underlying medical conditions.

...

There were no significant differences between the two groups in time to symptom resolution or rates of mechanical ventilation, intensive care unit (ICU) admission, 28-day in-hospital death, or adverse events.

...

"The study findings do not support the use of ivermectin for patients with COVID-19," the authors concluded.

 

https://www.cidrap.umn.edu/news-perspective/2022/02/ivermectin-futile-mild-moderate-covid-19-study-finds

 

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2789362

 

 

 

 

[onthedarkside]

And more out today:

Ivermectin Didn’t Reduce Covid-19 Hospitalizations in Largest Trial to Date

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.

 

(more)

 

https://www.wsj.com/articles/ivermectin-didnt-reduce-covid-19-hospitalizations-in-largest-trial-to-date-11647601200

 

AND

 

“There was no indication that ivermectin is clinically useful,” said Edward Mills, a lead investigator of the trial and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario.

...

The latest trial conducted in Brazil involved 1,358 adults with COVID-19 symptoms.... Half of them received Ivermectin pills for three days, and the other half received a placebo.

...

For accuracy, they analyzed data in three different ways, and in each scenario, ivermectin was found to have no impact on the improvement of patient outcomes."

 

(more)

 

https://seekingalpha.com/news/3815030-ivermectin-had-no-clinical-benefit-against-covid-19-in-largest-study-so-far

 

[onthedarkside]

A repost of previously removed dubious information content has been removed, along with ensuing replies.

 

Once a moderator has removed a post and posted a notice here explaining why, please do not attempt to re-post the same content.

 

"A post citing a nearly year-old 2021 summary recycling some past research findings on ivermectin -- in which the journal where it was published has posted a public notice noting questions about the accuracy of data included in some of prior research reviewed -- has been removed."

 

 

[mikebike]

18 hours ago, onthedarkside said:

And more out today:

Ivermectin Didn’t Reduce Covid-19 Hospitalizations in Largest Trial to Date

Patients who got the antiparasitic drug didn’t fare better than those who received a placebo

Researchers testing repurposed drugs against Covid-19 found that ivermectin didn’t reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic.

 

(more)

 

https://www.wsj.com/articles/ivermectin-didnt-reduce-covid-19-hospitalizations-in-largest-trial-to-date-11647601200

 

AND

 

“There was no indication that ivermectin is clinically useful,” said Edward Mills, a lead investigator of the trial and a professor of health sciences at Canada’s McMaster University in Hamilton, Ontario.

...

The latest trial conducted in Brazil involved 1,358 adults with COVID-19 symptoms.... Half of them received Ivermectin pills for three days, and the other half received a placebo.

...

For accuracy, they analyzed data in three different ways, and in each scenario, ivermectin was found to have no impact on the improvement of patient outcomes."

 

(more)

 

https://seekingalpha.com/news/3815030-ivermectin-had-no-clinical-benefit-against-covid-19-in-largest-study-so-far

 

Yeah. You are quoting the exact same study as the O.P.

[onthedarkside]

1 hour ago, mikebike said:

Yeah. You are quoting the exact same study as the O.P.

 

Not the same.

 

The OP  report is based on an April 2021 journal article involving a study that tracked more than 400 participants in Columbia thru December 2020.

 

 

JAMA. 2021 Apr 13;

"A total of 476 adult patients with mild disease and symptoms for 7 days or fewer (at home or hospitalized) were enrolled between July 15 and November 30, 2020, and followed up through December 21, 2020."

"Double-blind, randomized trial conducted at a single site in Cali, Colombia."

 

https://pubmed.ncbi.nlm.nih.gov/33662102/

https://plus.mcmaster.ca/COVID-19/Article/Details/33662102

 

The report in the Wall Street Journal this week covered the following:

 

"The latest trial conducted in Brazil involved 1,358 adults with COVID-19 symptoms."

"The findings have been accepted for publication in a major peer-reviewed medical journal."

 

https://seekingalpha.com/news/3815030-ivermectin-had-no-clinical-benefit-against-covid-19-in-largest-study-so-far

 

[LALes]

I had Covid a week ago.  I took 6 Ivermectin pills over 3 days and didn't notice anything.  I got better relief

with Advil for the headache and bodyaches.

[tonray]

10 minutes ago, LALes said:

I had Covid a week ago.  I took 6 Ivermectin pills over 3 days and didn't notice anything.  I got better relief

with Advil for the headache and bodyaches.

You likely prevented your parasitic worms from getting Covid

[onthedarkside]

A post linking to a YouTube COVID misinformation video has been removed, along with an ensuing reply.

 

[Maestro]

I have removed some more replies to removed posts.

[Puccini]

Has the Thai government ever approved or recommended the use of ivermectin for the treatment of Covid-19? If not, why do we discuss its uselessness here? Is it to bait the conspiration theorists and the spreaders of false information?

[partington]

3 hours ago, Puccini said:

Has the Thai government ever approved or recommended the use of ivermectin for the treatment of Covid-19? If not, why do we discuss its uselessness here? Is it to bait the conspiration theorists and the spreaders of false information?

No, it is to inform people who may be misled by postings of false information that ivermectin is efficacious in treating Covid of the actual truth that it isn't, and citing the evidence on which this is based.

 

[onthedarkside]

A series of off-topic posts have been removed.

 

[CartagenaWarlock]

Ivermectin is very popular among seditionists in the USA. They will ask for anything that is not recommended by the medical professional.

Edited March 26, 2022 by onthedarkside
trolling comment removed

[Danderman123]

With the Russian bot farms diverted to messaging about Ukraine, there isn’t any further propaganda about Ivermectin so nobody much cares about it.

 

The Russians did their job in convincing millions of people to not get vaccinated and instead take horse medicine. This sort of boomeranged on them due to so many Trump supporters dying from Covid.

 

At any rate, I doubt many Thais fell for the Ivermectin scam, maybe just a handful of Farangs.

[Tony125]

COVID SCIENCE-Vaccination after COVID improves immunity; ivermectin fails in major trial

 

https://www.msn.com/en-us/health/medical/covid-science-vaccination-after-covid-improves-immunity-ivermectin-fails-in-major-trial/ar-AAVLxZI?ocid=Peregrine&cvid=5e9907960b60471ba87528330c4b1960

[EVENKEEL]

Design, Setting, and Participants: Double-blind, randomized trial conducted at a single site in Cali, Colombia.

 

 The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand the effects of ivermectin on other clinically relevant outcomes.

 

Let's just say for argument sake the findings had been positive, the opponents to Ivermectin would have laughed it off as a fake study done in a Third world country and it never would have been posted or even allowed to be posted.

 

[Bkk Brian]

1 hour ago, Tony125 said:

COVID SCIENCE-Vaccination after COVID improves immunity; ivermectin fails in major trial

 

https://www.msn.com/en-us/health/medical/covid-science-vaccination-after-covid-improves-immunity-ivermectin-fails-in-major-trial/ar-AAVLxZI?ocid=Peregrine&cvid=5e9907960b60471ba87528330c4b1960

Just another one to add to the list yet we still have some swearing allegiance to it. 

[Adumbration]

Works a treat on my chihuahuas.

[CharlieH]

Given the amount of remo ed posts, this is just one more turn of the same carousel with same arguments,

 

CLOSED.