Promising news on a new Dengue vaccine

[GroveHillWanderer]

It's only the results of a phase 3 trial but that means it may not be too far away from getting approval and it's better than any of the currently available options in that it requires only a single dose and is suitable for people who've not had Dengue before.

 

Single-Dose Dengue Vaccine Provides Nearly 80% Protection

 

According to the linked article:

 

Quote

This vaccine was safe and effective with a single dose and protected a wide age range regardless of previous infection.

 

Edited February 8 by GroveHillWanderer

[retarius]

This seems like great news and it is a live attenuated tetra talent vaccine, none of the mRNA poison that we got with the COVID gene experiment. I would take it being in a vulnerable group and having known several farangs who have had it and been seriously ill. These is no treatment except supportive care. 

[mfd101]

But are we sure it won't actually CAUSE Covid 19?

[ross163103]

It's just the way it is, but I wonder why it's not for individuals 60+ and why it won't work for those previously infected. I'm above sixty and have had dengue once and obviously don't want to get it again. I keep reading these articles hoping they come up with a vaccine which will work for ALL cases. 

[pixelaoffy]

The Qdenga Vaccine currently used is only available for anyone up to 60 years old. Which seems crazy. Older folk get infected 

[john donson]

anybody still want to take shots after what is coming out slowly , which was conspiracy years ago and banned and censored but slowly dripping here and there... 10% more mortality ...  what was the news recently here... 500.000 less thais then a few years ago...

[Sheryl]

7 hours ago, john donson said:

anybody still want to take shots after what is coming out slowly , which was conspiracy years ago and banned and censored but slowly dripping here and there... 10% more mortality ...  what was the news recently here... 500.000 less thais then a few years ago...

 

1. There was no "conspiracy".

 

2.  The  Denvaxia vaccine (first Dengue vaccine developed, launched around 2016)  is effective in reducing dengue infections by about 80% in people who have had dengue before but only by about 50% in people who have never had dengue. Most importantly, among people who did not previously have dengue, received the vaccine and still got dengue, a higher percentage of them got a severe form of the disease. There is no clear evidence of increases deaths as a direct result (much less "10% mortality") but there were definitely more complications  leading to more serious illness and hospitalization among this group. This mainly played out in the Philippines which was the first place to widely launch the vaccine.

 

3. Far from being "banned" or "censored" this finding was widely publicized and led to a revision of guidelines for vaccine use, limiting it to people confirmed to have had dengue in the past.

 

One could legitimately criticize the vaccine developers for not having known of this effect sooner (i.e. before releasing the vaccine), especially since a re-analysis of the clinical trial data also found this effect.  But there was no intentional conspiracy and certainly no cover-up.

 

4. Revised guidelines limiting  the vaccine to people with a prior dengue infection were issued  in  2017 and the vaccine became available in Thailand only in that same year (and even now, is not part of the standard childhood immunization schedule and has nto been widely administered) so the impact of the original failure to recognize need to limit vaccination to people who had already had dengue in Thailand was minimal. It is certainly not an explanation for population decline. This - which began circa 2020 -  is directly the result of a decline in birth rate.

 

5. The new vaccine (Qdenga) appears to be  free of this effect i.e. rates of complicated dengue/hospitalization are nto higher in those without prior history of dengue before receiving the vaccine.

 

Qdenga has thus far been tested only on people aged 4 - 60 years so recommendation for use is limited to that group. It decreases risk of getting dengue overall only by about 60% but risk of severe dengue by about 80% (some variation by dengue serotype and prior immune status).

 

 

[Elkski]

Dengue is a concern fir me when i spend time in Thailand.  It sounds horrible.   We usually spend time in the village sleeping under a net.  The mozzys are always getting in.  Wife dies a sweep with the shock wand each night.  Dont know how 4-5 get in during the day.   Could really ruin a vacation or life.   I have read it is in the South East USA. 

[GroveHillWanderer]

On 2/9/2024 at 8:30 AM, ross163103 said:

It's just the way it is, but I wonder why it's not for individuals 60+ and why it won't work for those previously infected.

That's not what the article says - it says this vaccine is actually more effective for those that have had a previous infection. As it states:

 

Quote

Furthermore, the vaccine was 79.6% effective in those with no evidence of previous dengue infection, and 89.2% effective in those who had previous infection.

 

And the results of this study don't mean that a person over 60 absolutely can't have this vaccine. The thing is just that since It was only tested on people under 60, that's the only age range they can actually recommend it for. That's not to say it wouldn't be safe and effective for people over 60 - for example, if it works on a 59 year-old, why wouldn't it work on a 61 year-old?

 

Though all things being equal, it's probably slightly less effective for older people, given that this is virtually always the case with almost all vaccines.

 

There's also a chance that they will do further studies to gauge its effectiveness in older age groups at a later date.

[Tropicalevo]

Options have been available for a while.

Friends went to the local private hospital for theirs.

https://www.bangkokhospital.com/en/package/new-type-of-preventive-vaccine-for-dengue-fever

[GroveHillWanderer]

Yes, there are options but only two of them, one of which is not recommended unless you've had dengue before, and the other one requires two injections to be effective.

 

Although this vaccine is not fully approved or available yet, the potential advantages to it would seem to be that it's efficacious and safe regardless of whether you've had a previous infection or not and that it only requires one shot to be safe and effective.

Edited February 10 by GroveHillWanderer