December 22, 2025Dec 22 7 minutes ago, NanLaew said: No. Isn't that a body building supplement? https://www.uclahealth.org/news/article/why-everyones-talking-about-creatine “People who take creatine may see a small rise in their blood creatinine levels, but that does not necessarily mean their kidneys are being damaged,” she says. “It simply means their doctor may need to look more closely when checking kidney function.”
December 22, 2025Dec 22 8 minutes ago, CallumWK said: Body builders take it also since it promotes muscle healing, but it is also suggested for older people https://my.clevelandclinic.org/health/treatments/17674-creatine While there is no evidence that it harms the kidneys, I believe it may affect eGFR test results, as it may increase creatine levels in the blood. Good to know, thanks. The only two supplements I take are pumpkin seed oil (prostate health) and glucosamine chondroitin (for irregular and infrequent joint pain). The former I started about 8 months ago - a couple of months before the medical, the latter I've been taking off and on for over 10 years. Tonight's dinner supplement is a Wexford's Irish creme ale.
December 22, 2025Dec 22 6 minutes ago, NanLaew said: The only two supplements I take are pumpkin seed oil Pumpkin seed oil itself doesn't contain creatine , but pumpkin seeds are rich in the amino acids (arginine, glycine) needed for your body to make creatine, and research suggests pumpkin seed oil may support hormones like testosterone, which relates to muscle health, but its primary uses are for prostate, urinary, and hair health, acting as a natural DHT blocker. Pumpkin Seed Oil & Creatine Connection Building Blocks: Pumpkin seeds provide arginine and glycine, the amino acid precursors your body uses to synthesize its own creatine, making them good for vegans seeking to boost creatine production naturally. No Direct Creatine: The oil and seeds are not a direct source of creatine, but they supply the raw materials.
December 22, 2025Dec 22 20 minutes ago, CallumWK said: Pumpkin seed oil itself doesn't contain creatine , but pumpkin seeds are rich in the amino acids (arginine, glycine) needed for your body to make creatine, and research suggests pumpkin seed oil may support hormones like testosterone, which relates to muscle health, but its primary uses are for prostate, urinary, and hair health, acting as a natural DHT blocker. Pumpkin Seed Oil & Creatine Connection Building Blocks: Pumpkin seeds provide arginine and glycine, the amino acid precursors your body uses to synthesize its own creatine, making them good for vegans seeking to boost creatine production naturally. No Direct Creatine: The oil and seeds are not a direct source of creatine, but they supply the raw materials. Good info, thanks. I doubt a couple of months of these has rocketed me into CKD 2 though. I don't even do the recommended 3 x daily after meals, only once after the main meal of the day.
December 22, 2025Dec 22 On 11/21/2025 at 12:44 AM, roger buttmore said: 5 months later and I've lost 2½ stone (36lbs / 16kg). Down from 96kg to just under 80kg. It becomes a lifestyle and is no problem to maintain and continue. The effort required is minimal, just some determination and self-control, which becomes much easier over time. That's a lot of work. Good job.
December 22, 2025Dec 22 5 minutes ago, NanLaew said: Good info, thanks. I doubt a couple of months of these has rocketed me into CKD 2 though. I don't even do the recommended 3 x daily after meals, only once after the main meal of the day. You didn't mention your previous and current levels, but the difference between stage 1 and 2 can be only a few points. Like 92 previously and 85 now.
December 22, 2025Dec 22 On 11/21/2025 at 7:50 PM, Hummin said: Which all of it for most is a result of lifestyle health problems. If everyone maintain a healthy active lifestyle from young, there wouldn't be much differences in metabolism among larger groups. A balanced diet and general healty active lifestyle would had prevented most people's metabolism issues or problems unless there is a medical illness or drug use causes lower metabolism. <snip> Wouldn't you agree that people's metabolic responses to various chemicals differ?
December 22, 2025Dec 22 1 hour ago, Peabody said: Wouldn't you agree that people's metabolic responses to various chemicals differ? Based on what I have read, most people do not show much difference, even among larger groups, but for some individuals there is a difference, yes. I am very sensitive to medication and other substances and tend to react differently than most people, so I have to be careful and avoid using too much. When you know you have an issue, you should take it into consideration rather than ignoring it, and make the necessary changes.
December 22, 2025Dec 22 32 minutes ago, Hummin said: most people do not show much difference, even among larger groups, But there are YUGE differences in people's responses to medicinal chemicals. Why doesn't a specific drug have the exact same effect in even large, homogeneous groups of individuals? Different side effects, different efficacy, different clinical responses... And the same questioning can easily be used for the varied responses to nutritional chemicals. Metabolism.
December 22, 2025Dec 22 3 minutes ago, Peabody said: But there are YUGE differences in people's responses to medicinal chemicals. Why doesn't a specific drug have the exact same effect in even large, homogeneous groups of individuals? Different side effects, different efficacy, different clinical responses... And the same questioning can easily be used for the varied responses to nutritional chemicals. Metabolism. This is how I wanted to explain it the simple way, but I also checked with ai to make ai to explain it A bit better why people experience different on medications comes down to your diet, health and delivery proteins Yes, your statement is spot-on: how you experience medication varies due to diet, overall health, and proteins, because food alters drug absorption/metabolism, underlying conditions affect drug processing, and proteins (like albumin & lipoproteins) transport drugs, all changing drug levels, effectiveness, and potential side effects . Your body's unique biology, genetics, and current state create a complex "factory" that processes medications differently from person to person. Diet (Food-Drug Interactions) Absorption: Grapefruit juice blocks enzymes, increasing statin levels; Vitamin K in leafy greens alters blood thinners; high-fat meals slow absorption. Metabolism: High-protein diets can speed up drug breakdown by stimulating liver enzymes (cytochrome P-450). Elimination: Calcium in dairy can bind antibiotics like tetracycline, preventing absorption. Health (Physiological Factors) Liver/Kidney Function: These organs process and eliminate drugs; impaired function (due to disease or inflammation) can cause buildup and toxicity. Inflammation: High inflammation (indicated by C-reactive protein) can suppress drug metabolism. Genetics: Genetic variations in drug-processing enzymes (like RGS proteins) cause cells to respond differently to the same drug. Delivery Proteins (Distribution) Plasma Proteins: Drugs bind to proteins like albumin and lipoproteins (cholesterol carriers) in the blood. Free vs. Bound Drug: Only "free" drug is active; bound drug is inactive but can be released later. Lipoprotein Impact: Changes in lipid profiles (from diet or disease) alter how much drug reaches target cells, affecting both efficacy and toxicity. In essence, diet, underlying health (like inflammation or liver health), and your body's protein "shuttles" all influence a drug's journey from ingestion to action, explaining the wide range of individual responses
December 22, 2025Dec 22 7 minutes ago, Hummin said: (cytochrome P-450) Great example of what I'm saying. Clear DNA sequence differences can be linked directly to the rate of the various CYP450 enzymes' actions and effects. This variability occurs naturally, probably randomly, too, although certain mutations may occur more frequently. So, there are built-in differences, probably NOT linked to post-partum factors. Heres one paper: https://pubmed.ncbi.nlm.nih.gov/24257813/
December 22, 2025Dec 22 8 hours ago, NanLaew said: I had my annual medical last summer, all good considering the high mileage. All markers in spec. This summer, I had the same medical at the same hospital and CKD stage 2 suddenly gets mentioned. I did a bit of sleuthing and apparently there are 5 stages, with 1 being variously described as 'virtually undetectable' which made me think why on earth have it at all? Start the early warning system with the current stage 2 (reversible) as stage 1. Then there may be a better chance of avoiding, or delaying the onset of the "irreversible" stage 3 and beyond. Maybe big pharma invented CKD? If dehydrated and/or too much salt around that time of the test eGFR will drop, if concerned hydrate well for a week or so, less salt and re-test, Cystatin C also a good follow up test to exclude food and creatine as a cause
December 22, 2025Dec 22 9 hours ago, NanLaew said: Start the early warning system with the current stage 2 (reversible) as stage 1. I was about to say comments like this should be in the Wellness Zone but it already is.
December 23, 2025Dec 23 4 hours ago, scubascuba3 said: If dehydrated and/or too much salt around that time of the test eGFR will drop, if concerned hydrate well for a week or so, less salt and re-test, Cystatin C also a good follow up test to exclude food and creatine as a cause Good info, thanks. Normal (identical) 8-hour fasting done before each medical. No notable changes in dietary habits over the 12-months apart from less alcohol and red meat and more veg.
December 23, 2025Dec 23 3 hours ago, jerrymahoney said: I was about to say comments like this should be in the Wellness Zone but it already is. Thanks, I'll check it out. Back on topic, I have always been aware of how easy it is to slip into type 2 diabetes as you progress through middle age. I worked with a guy in LA who measured his Interstate road trips in piss stops rather than time or distance. Middle management, in his mid-forties, beer gut, cigars and no visible signs of exercise.
December 23, 2025Dec 23 21 minutes ago, NanLaew said: Thanks, I'll check it out. The quote of mine above from the Health Forum is that Kidney damage is not reversable. It was not about diabetes although diabetes is the leading cause for kidney damage.
December 23, 2025Dec 23 5 minutes ago, jerrymahoney said: The quote of mine above from the Health Forum is that Kidney damage is not reversable. It was not about diabetes although diabetes is the leading cause for kidney damage. I understand. I misspoke when i mentioned reversible with regard to CKD in my previous post. It's manageable, especially in CKD 2, but it's not reversible.
December 25, 2025Dec 25 According to one doctor: If you have 3 out of the 5 markers below or more, you need to be concerned.
December 25, 2025Dec 25 On 11/21/2025 at 10:11 AM, BritManToo said: I'd rather be dead than give up carbs and sugar. What do us old folk have left beyond eating and drinking? We all have nature. It is there for us. Go for a barefoot walk in the forest. Listen to the birds twittering to each other. See the rustling of the trees. If you are lucky enough to see a squirrel; observe how it uses its tail. Find a pond. Sit and watch as birds swoop down to catch fry. Ditch the sex, sugar and beer. Appreciate what is really important.
December 25, 2025Dec 25 23 minutes ago, Stiddle Mump said: We all have nature. It is there for us. Go for a barefoot walk in the forest. Listen to the birds twittering to each other. See the rustling of the trees. If you are lucky enough to see a squirrel; observe how it uses its tail. Find a pond. Sit and watch as birds swoop down to catch fry. Ditch the sex, sugar and beer. Appreciate what is really important. Pit vipers and scorpions all around Chiang Mai ...... You'd have to be mad to walk barefoot.
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