Four types of Made-in-Thailand COVID vaccines to begin human trials

[snoop1130]

 

BANGKOK(NNT)- Thailand is developing multiple types of vaccine and most of them are entering into human trials this year. Today we’ll look into 4 types showing the most promising results.

 

The first type is made-in-Thailand mRNA vaccine developed by the Vaccine Center of Chulalongkorn University. It was previously tested in volunteers in the first phase and shows 94% efficacy, as good as other global mRNA types. The result shows that it can successfully suppress 4 strains including Alpha, Beta, Gamma and Delta and induces T-cell responses as well.

 

The advantage of such a type is that it can be refrigerated (2-8C) for up to 3 months and stored at room temperature (25C) for 2 weeks, making it easier to store than other mRNA vaccine brands. It also has only slight side effects.

 

The second human trial is expected this month, with manufacturing expected in October 2022

 

The second type is inactivated HXP-GPOVac developed by the Government Pharmaceutical Organisation with its international partners. It uses inactivated and genetically modified Newcastle disease virus (NDV) to express HexaPro or a stabilized spike protein of the coronavirus on the surface, to enable the human immune system to recognize and to defend itself against the infection.

 

This new vaccine has the advantage of being capable of cultivation in embryonated eggs, a method also used in flu vaccine manufacture; thereby making the manufacturing process inexpensive. The GPO says the vaccine can be produced at the GPO’s industrial-scale plant, resulting in around 20-30 million doses per year.

 

With a second human trial being conducted, the GPO expects to begin manufacturing the vaccine in the middle of 2022.

 

The third type is a nasal spray type developed by The National Center for Genetic Engineering and Biotechnology (BIOTEC). It can be sprayed into the nasal cavity through a special syringe designed to deliver the vaccine directly to the mucous membrane of the upper respiratory system, where most of the viruses including COVID-19 form, before being distributed all over the body. This vaccine has two kinds - Adenovirus-based, and Influenza-based.

 

With its inhaling function, it can be used more easily than the injected kind.

 

the first clinical human trial is expected to be conducted at the end of this year and manufacturing may start in the middle of 2022.

 

The last type is a vaccine developed by pharmaceutical startup called Baiya Phytopharm, in collaboration with the Faculty of Pharmacy of Chulalongkorn University. The vaccine uses tobacco leaves as plant platform to express antigens and be made into the vaccine.

 

As this is a vaccine using a plant platform, in case of future mutations of the virus, researchers can take the genetic code of new strains to produce a vaccine immediately and there’s no need to wait for an imported one.

 

It is now planning the first human trial and If successful, the third quarter of the year 2022, will be the first month of production.

 

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-- © Copyright NNT 2021-08-20

 

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[Scrotobike]

I fear them.

[steven100]

yikes     !     no way i'm putting any thai made vaccine into my body.       run forest run !!

 

would you trust a Thai   ?       lol

[steven100]

41 minutes ago, snoop1130 said:

The vaccine uses tobacco leaves as plant platform to express antigens and be made into the vaccine.

might be ok at for the smokers to take a puff at lunch break.

[jaltsc]

"The vaccine uses tobacco leaves..."

 

Brought to you by the hub of pipe dreams. 

[JerseytoBKK]

The 2nd vaccine is being tested in multiple countries. It is based on research from highly respected Mt. Sinai in New York City in collaboration with Texas University. Funded by WHO and PATH. I've been following this for 5 months because they are using a component from a small biotech company that I have a lot of shares in.

 

 

 

Edited August 20, 2021 by JerseytoBKK

[chalawaan]

Intravenous alcohol with a massage to ease bladder congestion should be a miracle cure. When the victims die, who cares? They laid down their baht for the financial freedom of all slimkind. 

[Nojohndoe]

Stupid  stupid comments ! Global attempts to produce a vaccine effective  against covid-19 number in the  100's. That 4  purportedly based in Thailand have made it as  far as human trials is positive news. That even one  eventually proves  viable efficacy etc is one step closer to equitable provision of protection for those who choose it.

[Nojohndoe]

I feel obliged to add that there is an obvious expectation that a year from now the need for effective  vaccines will still be considered a necessity and that is before other concerning variants may arise.

If not then at least the capacity and tech knowledge will exist if yet another contagion erupts .

 

[jak2002003]

 

Good grief! 

 

What is all this extra time wasting and money wasting happening for?

.

Why can't they simply follow what the rest of the world is doing?

.

They akready have a factory producing a high quality, world recognise vaccine right here in thailand. How about using what they produce? 

[EricTh]

By the time these vaccines are tested and produced, most people in Thailand will already have been vaccinated with other vaccines.

 

I plan to get my third booster shot after 6 months but after that, there's no need for any more Covid vaccine. 

 

It's a waste of money.

 

Why didn't they start doing this early last year?

 

 

Edited August 20, 2021 by EricTh

[gk10012001]

I am pretty sure things similar to this have or are being looked at in other countries.  The egg incubation may be inexpensive but that takes time.  And just like with the flu vaccines, they have to guess which strains to grow and hope that is the one that will be effective against virus xyz and its variants

[Nyonya]

Stay away!!!!!!!!! ????

[hotchilli]

11 hours ago, steven100 said:

yikes     !     no way i'm putting any thai made vaccine into my body.       run forest run !!

 

would you trust a Thai   ?       lol

Think i'll stick with Astra, I know it's made here but quality control is overseen.

[mtls2005]

Under the "Advantages" column I'd like to see "Efficacious: Yes"

 

 

[Tony125]

The Thai Mrna vaccine if passes trials could begin manufacturing in October  "2022" ?    I really hope they are not waiting for that one. May be able to sell to some poor African or South American countries by then  but I hope by that time it's really not needed here.

[George Aylesham]

16 hours ago, Nojohndoe said:

Stupid  stupid comments ! Global attempts to produce a vaccine effective  against covid-19 number in the  100's. That 4  purportedly based in Thailand have made it as  far as human trials is positive news. That even one  eventually proves  viable efficacy etc is one step closer to equitable provision of protection for those who choose it.

I agree - why are so many posters condescendingly denigrating Thailand's efforts to provide healthcare at a time of vaccine famine?

[sawadee1947]

Too late I suppose 

[Nojohndoe]

Sneer on. But also consider that the claims were adamant that a simple "tweak" could be made for the dominant vaccines to cope with variants.

The original mRNA vaccines were developed and approved for emergency use in about 6 months.

The Delta variant arose 9 months ago and has gained dominance in infections globally.

Has anyone heard one peep about any "Tweaks" ?

If multiple countries, even by way of collective R&D, can successfully make those countries less beholden to foreign corporate and political manipulation then gaining the capacity is an asset in that sense alone. Not a wise thing to ignore the application of that technology to any new or even existing diseases.

[khaowong1]

On 8/20/2021 at 7:27 AM, Scrotobike said:

I fear them.

When they say Human trials, I run. 

[spermwhale]

10 hours ago, sawadee1947 said:

Too late I suppose 

COVID is going to be with us for a long long time and the main vaccine producers do not have the capacity to make enough vaccine to inoculate the world. The more choices the better. If any of these pass clinical trials and can be produced, it will all help. 

For certain. COVID will be with us a year from now. It's never going away. 

 

[sawadee1947]

11 hours ago, spermwhale said:

COVID is going to be with us for a long long time and the main vaccine producers do not have the capacity to make enough vaccine to inoculate the world. The more choices the better. If any of these pass clinical trials and can be produced, it will all help. 

For certain. COVID will be with us a year from now. It's never going away. 

 

In general I might agree. 

However, with slow and ineffective vaccinations you'll create new variants. And if Thais will produce ä vaccine similar to Biontech there will be no benefit. 

It's better to put all money and efforts to maximise the production of AZ and throw the Chinese stuff into a bin. 

Also, the Western countries are far ahead and can easily change their vaccine if necessary in case there will be a new variant making eg Biontech ineffective (statement of Sahin, "inventor" of Biontech)