I want to address this because you mentioned "come on people do your own research..wake up !!!"... while presenting a one sided argument that omits facts. So here is what has been 'stated' / said by Dr.Robert Maole about the LNP tech, but firstly a quick but important caveat first: the "inventor" title is contested. Malone did early foundational work in 1989 showing mRNA mixed with lipid droplets could get cells to produce protein, but the first lipid nanoparticle itself was actually developed by his collaborator Phil Felgner, and mainstream science writers note it took decades of further innovation from other labs to get to the actual COVID vaccines - So whole Maole did real early work in 1989, calling him "the inventor" is like crediting the Wright brothers with inventing the A380 - they got something off the ground first, but what actually flies today is a different machine built by generations of engineers after them. Firstly I'll address what was 'said / claimed' by Maole: Biodistribution claims: Malone has said LNPs leave the injection site and circulate through the body rather than staying at the deltoid muscle, based on a Japanese biodistribution study, accumulating in the spleen, bone marrow, liver, adrenal glands, and in particularly high concentrations in the ovaries. He's called for monitoring vaccine recipients for leukemia and lymphoma given the concentrations found in bone marrow and lymphatic tissue. Regulatory/manufacturing concerns: More recently he's argued that residual DNA plasmid fragments delivered via the LNP formulations in Comirnaty and Spikevax present real and uncharacterised risk, and has said the products should be pulled from market until adequately tested, and has criticised FDA official Peter Marks's responses on this as unsupported, misleading, and not scientifically rigorous. LNP toxicity generally: He and Jill Malone have written that LNPs and the positively charged lipids used in them don't occur naturally and their self-assembly and breakdown aren't well-controlled processes, and he's stated he could never overcome toxicity issues with lipid-based mRNA/DNA delivery in his own earlier work in the 1990s, which is part of why he shelved that approach. It should also be worth noting his biodistribution/ovary claims are largely drawn from a single Japanese Pfizer biodistribution study in rats, not human data, and the leukemia/lymphoma link is Malone's own inference from tissue concentration, not an established finding in human epidemiological data. Now I'll address what actually undercuts each of Malone's claims: On "the LNPs go everywhere and pile up in the ovaries": This traces back to one Japanese biodistribution study, which was done in rats, not humans, using a radiolabeled tracer to track where the lipid component goes. The finding was real: highest concentrations at the injection site and draining lymph nodes, but detectable amounts in the liver, spleen, adrenal glands, and ovaries too. What Malone and others left out is scale and duration. The ovarian concentration was small relative to the injection site and liver, and follow-up studies designed to look at persistence found that LNP components and spike protein were transient, with no evidence of persistence beyond 1-2 weeks after injection. The "manufacturing plant in the ovaries" framing that circulated from this data has been directly fact-checked as false by reviewers who note there's no evidence of increased adverse pregnancy outcomes or fertility effects in the real-world data collected since. On human blood pharmacokinetics: A 2024 human study tracking actual vaccine mRNA and lipid levels in blood after a Moderna booster found peak levels at 1-2 days post-vaccination, with mRNA still detectable in only 37% of subjects by day 14-15. That's consistent with clearance, not persistent accumulation. It's a different picture from "circulates indefinitely and builds up in organs." On the leukemia/lymphoma monitoring call: This is Malone's own inference from tissue concentration data, not a finding in actual surveillance data. Years of pharmacovigilance across VAERS, the UK Yellow Card scheme, and European databases haven't shown an elevated signal for leukemia or lymphoma tied to vaccination. If LNP accumulation in bone marrow were driving malignancy, you'd expect that to show up in population-level cancer registries by now, and it hasn't. On the DNA plasmid fragment concern: The FDA and EMA have both addressed residual plasmid DNA levels as being within long-established regulatory limits for biologics, and regulatory reviewers have pushed back specifically on Malone's framing that this represents an unaddressed genotoxicity risk, saying existing genotoxicity and biodistribution data doesn't support that conclusion. Malone's position here is a minority one within the field, not something that mainstream reviewers have accepted as an open regulatory gap. Also of key importance in this debate: in the interest of balance and fiarness: A recent scientific review of biodistribution studies makes the point that this remains a genuinely under-studied area overall, so "nothing to see here" isn't quite the right framing either. The honest position is: some LNP does circulate beyond the injection site, that's established, but the claims about persistence, organ accumulation being dangerous, and cancer risk go well beyond what the data actually shows. So.. Biodistribution happens, that part's true. Malone isn't wrong that LNPs reach the ovaries in tiny amounts. He's wrong about what that means, and that's the half of the story you left out. Follow-up studies show no persistence past 1-2 weeks, and years of surveillance data show no leukemia or lymphoma signal. Citing the data point while skipping the data that contradicts the conclusion isn't a rebuttal, it's cherry-picking. And again - this is why these threads are exhausting - it take a lot longer to respond to missinformation, incomplete infirmation, cherry picked misrepresentative data than it does to make the initial misinformation claim in the first place. I didn't want to reply with a simple 'one liner' - "your data is incomplete, dated and cherry picked" - but ultimately thats exactly what it is, and thats whats outlined above.
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