Human trials of first Thai developed COVID-19 vaccine begins Monday

[webfact]

 

Human trials of the first Thai COVID-19 vaccine, developed by Chula Vaccine Research Centre (CVRC) at Chulalongkorn University and King Chulalongkorn Memorial Hospital, began today (Monday).

 

Called “ChulaCov19”, it is the first vaccine developed in Thailand, but will be the second to be locally made, if approved, after Siam Bioscience’s production of the UK’s AstraZeneca vaccine.

 

It is also an mRNA vaccine, a type that provides instructions to human cells on how to make a “spike protein” that triggers the body’s immune response.

 

Full story: https://www.thaipbsworld.com/human-trials-of-first-thai-developed-covid-19-vaccine-begins-monday/

 

-- © Copyright Thai PBS 2021-06-15

 

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[RichardColeman]

 

40 minutes ago, webfact said:

Called “ChulaCov19”

Sounds like something from Jive Bunny !

[Albert Zweistein]

They copied AZ ?

[kotsak]

Just now, Albert Zweistein said:

They copied AZ ?

AZ is not an mRNA unless they got confused which wouldn't be surprising.. ????

[Albert Zweistein]

11 minutes ago, kotsak said:

AZ is not an mRNA unless they got confused which wouldn't be surprising.. ????

Exactly what I mean.

[gargamon]

Ahh, so  this is what they're using on the foreigners...????

[ezzra]

All i can wish those who will get the Thai vaccine is GOOOD Luck to them, they are brave people... 

[Bkk Brian]

Prayut back in Jan:

 

Thailand’s PM is saying he won’t let Thai people become vaccine “guinea pigs” in his Facebook post today as he points to reports of serious negative side effects that some people have suffered after getting jabbed with the Covid-19 vaccine.

https://thethaiger.com/news/national/thailands-pm-says-he-wont-let-thais-become-vaccine-guinea-pigs

 

 

From the article link in th OP

 

"The first phase involves 72 volunteers. Half are aged 18-55 and half 65-75. Some of them will get 10 micrograms (mcg) of the vaccine, while others will get 25mcg and 50mcg, to determine the most effective dosage. The second phase, involving 150-300 volunteers, will begin in August, if the first phase results are satisfactory.

If both phases of the trial prove high efficacy and safety of the vaccine, the third phase can be skipped and it could be approved for mass production before mid-2022, said Dr. Suttipong."

[J Town]

This is most likely the reason for bungling all other attempts. There's gold in them thar shots and those in power want that gold.

[Crossy]

Quote

If both phases of the trial prove high efficacy and safety of the vaccine, the third phase can be skipped and it could be approved for mass production before mid-2022, said Dr. Suttipong.

 

So, let me get this right, they are going to go full-bore production based upon the results from a sample size less than 400?

 

I think I would be placing this in the "unwise" box, the Western jabs have been hurried through but this borders on madness.

 

[nightfox]

Human trials is just a nice saying for guinea pigs.

[ThomasThBKK]

54 minutes ago, J Town said:

This is most likely the reason for bungling all other attempts. There's gold in them thar shots and those in power want that gold.

No. No.

 

This was not supported by the government, they literally don't want this to succeed.

 

 

 

Chula and mahidol are decent labs. They complain about those <deleted> in power all the time.

 

They begged for some funding and got nothing...

 

 

 

[realfunster]

41 minutes ago, Crossy said:

 

So, let me get this right, they are going to go full-bore production based upon the results from a sample size less than 400?

 

I think I would be placing this in the "unwise" box, the Western jabs have been hurried through but this borders on madness.

 

 

Fully agree mate. It rings of ‘local’ propaganda and these scientists trying to remain relevant.

 

That’s a tiny sample group and then they plan to possibly skip phase three for approval (whatever that means - by mid 2022). That is a year from now and production is not even mentioned….

 

The haste seems unnecessary as they have already missed the worst of the global outbreak, and although it is likely ongoing COVID vaccines may be required for some time, already established vaccines will be flooding the market by early next year. As for local use, well I presume even the delayed AZ from SB will be pumping out tens of millions of doses a month come year-end. 

 

So, I doubt come mid-2022 anyone is going to be particularly interested in a hastily approved, phase-3 skipping, tiny sample sized vaccine from Chula. 

 

[hotchilli]

2 hours ago, gargamon said:

Ahh, so  this is what they're using on the foreigners...????

Not this one.

[bradiston]

4 minutes ago, RobMuir said:

With people dropping off like flies with the Brit-swede Astrazeneca muck from blood clots, the Chinese syrup being quite ineffective, the USA Johnson and Johnson balls up and the impractical Pfizer rush job I am hopeful that the Thais will come up with something better.

Live in hope, die in hope. More poison in your post than in any vax.

[Excel]

10 minutes ago, RobMuir said:

With people dropping off like flies with the Brit-swede Astrazeneca muck from blood clots, the Chinese syrup being quite ineffective, the USA Johnson and Johnson balls up and the impractical Pfizer rush job I am hopeful that the Thais will come up with something better.

Yes what they really need is another Alexander Fleming type but I doubt the Thais have anyone of that ilk, the bum gun is about the Thai level of innovation.

[spidermike007]

This might have made sense if the trials started on April 2nd, 2020. But now? Why even bother? Just admit defeat, for once in your lives. 

 

Stop with the lies and deceptions. 

[mtls2005]

The project is a joint venture between Prof Kiat Ruxrungtham from the Center of Excellence in Vaccine Research Center and Development (ChulaVRC) and Professor Drew Weissman from the University of Pennsylvania. The vaccine will use mRNA technology to trigger an immune response against Covid-19, similar to the Pfizer-BioNTech and Moderna shots.

 

 

 

https://www.chula.ac.th/en/clipping/47302/

 

 

[Bkk Brian]

1 minute ago, RobMuir said:

Hope he can help.

I don't think it could have been done without him seeing as he sent the prototype

[TheFishman1]

He didn’t tie and then the vaccine for aids didn’t tie and then the vaccine for cancer and treatment so what’s next amazing Thailand TIT

[sathornlover]

3 hours ago, Bkk Brian said:

Prayut back in Jan:

 

Thailand’s PM is saying he won’t let Thai people become vaccine “guinea pigs” in his Facebook post today as he points to reports of serious negative side effects that some people have suffered after getting jabbed with the Covid-19 vaccine.

https://thethaiger.com/news/national/thailands-pm-says-he-wont-let-thais-become-vaccine-guinea-pigs

 

 

From the article link in th OP

 

"The first phase involves 72 volunteers. Half are aged 18-55 and half 65-75. Some of them will get 10 micrograms (mcg) of the vaccine, while others will get 25mcg and 50mcg, to determine the most effective dosage. The second phase, involving 150-300 volunteers, will begin in August, if the first phase results are satisfactory.

If both phases of the trial prove high efficacy and safety of the vaccine, the third phase can be skipped and it could be approved for mass production before mid-2022, said Dr. Suttipong."

 

When one reads something like this, one would not believe one's own eyes and senses if one completely forgets or does not know where this "vaccine development" is supposed to take place.

 

For comparison, I would like to refer to the long suffering of the Curevac vaccine, which presumably offers the same protection at a significantly lower dosage as the other successful mRNA vaccines and another advantage is that the active substance remains stable at a temperature of five degrees for at least three months.

 

Unfortunately, the 2-3rd phase only started in December 2020 and not enough infections could be detected in April-May as planned:

 

„The company said on May 28 that the late-stage trial involving about 40,000 volunteers in Europe and Latin America had reached a first interim analysis at 59 COVID-19 cases, but that more data would be necessary for statistically reliable efficacy numbers.“

 

But in fact at least 160 cases are needed, in Thailand this does not seem to be necessary.

 

Who would trust a vaccine where the proof of efficacy is completely lacking and the side effects are virtually unexplored due to the small number of test persons?

 

EU regulator does not expect approval for CureVac vaccine before August

[herfiehandbag]

2 hours ago, ThomasThBKK said:

No. No.

 

This was not supported by the government, they literally don't want this to succeed.

 

 

 

Chula and mahidol are decent labs. They complain about those <deleted> in power all the time.

 

They begged for some funding and got nothing...

 

 

 

That is very interesting.

 

If it works ( and I know nothing about the capabilities of the labs or scientists involved, but I hear what you say) I wonder under which (whose) auspices it will be put into production!

 

I read subsequently that they have a company lined up to produce it. That will of course have to be licenced, and as it will challenge a very important monopoly I could predict a problem there.

 

There may be gracious permission to produce it in an existing facility though, taking into account all the circumstances...

 

Edited June 15, 2021 by herfiehandbag

[clivebaxter]

2 hours ago, RobMuir said:

With people dropping off like flies with the Brit-swede Astrazeneca muck from blood clots, the Chinese syrup being quite ineffective, the USA Johnson and Johnson balls up and the impractical Pfizer rush job I am hopeful that the Thais will come up with something better.

 

How is 32 deaths in the UK out of over 21 million dropping like flies? 

 

https://medicalxpress.com/news/2021-04-uk-deaths-clots-az-jabs.html

Edited June 15, 2021 by clivebaxter

[fondue zoo]

Everyone wants a piece of the covid cake.

[ThomasThBKK]

13 minutes ago, herfiehandbag said:

That is very interesting.

 

If it works ( and I know nothing about the capabilities of the labs or scientists involved, but I hear what you say) I wonder under which (whose) auspices it will be put into production!

 

 

So far the samples are produced in the USA.

 

I am sure there will be some asian producer if it works out, hopefully outside of Thailand in Singapore, Korea or so....

[Boedog]

Start to human trials nothing like skipping the animal trials, l wonder how this will turn out

[Hanuman2547]

Luckily I have already been vaccinated with the Pfizer vaccine.  I'd pass on the Thai developed vaccine.

[Heng]

It seems every other day there is a news bit that says 'just fly to vaccinate and get it over with.'    

[Dont confuse me]

Just when you thought things couldn't get more screwed up!

You couldn't make this comedy of errors up! 

The government is a shambles and it's dragging the country down with it

[placnx]

5 hours ago, realfunster said:

 

Fully agree mate. It rings of ‘local’ propaganda and these scientists trying to remain relevant.

 

That’s a tiny sample group and then they plan to possibly skip phase three for approval (whatever that means - by mid 2022). That is a year from now and production is not even mentioned….

 

The haste seems unnecessary as they have already missed the worst of the global outbreak, and although it is likely ongoing COVID vaccines may be required for some time, already established vaccines will be flooding the market by early next year. As for local use, well I presume even the delayed AZ from SB will be pumping out tens of millions of doses a month come year-end. 

 

So, I doubt come mid-2022 anyone is going to be particularly interested in a hastily approved, phase-3 skipping, tiny sample sized vaccine from Chula. 

 

If the problem is a lack of money for Phase 3, why not appeal to Gates Foundation or GAVI? Of course by the time Phase 2 is done, it may be difficult to find study subjects who have not been exposed to Covid or been previously vaccinated, but there will still probably be many other countries with low vaccination rates for doing Phase 3 trials. With sufficient know how, by middle of next year they should be prepared to tweak the vaccine just as Pfizer and Moderna are doing to account for new variants. Then this vaccine can function as a booster for AZ.