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PM praises homegrown vaccine developments


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By Tanakorn Sangiam

   

BANGKOK (NNT) - With the development of four vaccine candidates in progress, the Prime Minister has praised the Thai scientists behind these projects which will play a crucial role in Thailand’s epidemic response, as well as reducing the country’s reliance on vaccine imports.

 

Deputy Government Spokesperson Rachada Dhanadirek, said today the Prime Minister has emphasized that domestic vaccine development and technology transfer, are the foundation of Thailand’s move towards self-reliance in vaccines, which will help the country save on vaccine imports, and present opportunities for vaccine exports in the future.

 

There are currently four COVID-19 vaccine candidates developed in Thailand, using different platforms and each at a different stage of research and trials.

 

The first Thai-made COVID-19 vaccine candidate to enter human trials is the NDV-HXP-S vaccine, developed by the Government Pharmaceutical Organization (GPO) and the Faculty of Tropical Medicine at Mahidol University. Developed in cooperation with PATH Center for Vaccine Innovation and Access; this vaccine is the vaccine also being trialed in Vietnam and Brazil.

 

If successful, the vaccine candidate can easily be produced at the GPO’s existing facilities using chicken eggs, similar to the current flu vaccines.

 

The second vaccine candidate, which entered Phase 1 clinical trials on 14th June, is an mRNA vaccine from Chulalongkorn University’s Center of Excellence in Vaccine Research and Development (Chula VRC). This vaccine candidate is developed on the mRNA platform, similar to Pfizer and Moderna, however with the advantage of being capable of up to 3 months storage at 2-8 degrees C, or up to 2 weeks at 25C.

 

Earlier trials with rats and monkeys show this vaccine candidate can help elicit a high antibody response, while the mRNA platform allows for a quick deployment and manufacturing of an updated vaccine to address newer variants.

 

The third vaccine candidate is a DNA vaccine developed by BioNet-Asia. The company is filing for human trials approval from the Food and Drugs Administration (FDA), following its trial in rats. The company is expected to conduct Phases 2 and 3 trials this year, with another Phase 1 trial in Australia conducted simultaneously.

 

Another vaccine candidate is the plant-based protein subunit vaccine by Baiya Phytopharm, a startup from Chulalongkorn University, which has successfully developed a vaccine prototype using tobacco leaves to create the antigen protein needed. Clinical trials of this vaccine candidate are expected to start in August-September.

 

Meanwhile, AstraZeneca has promised to complete the 6 million doses delivery being made by Siam Bioscience to the Thai government, while the 1.05 million doses AstraZeneca jabs donated by the Japanese government are expected to arrive in early-July.

 

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Though a bit late in the game. Better late than ever.

 The mPNA research is promising because it can be adjusted to apply to different strains and viruses. and since these viruses will be with us for a long time, it is a good idea not to be dependent on imports.  

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3 hours ago, sirineou said:

Though a bit late in the game. Better late than ever.

Was the typo meant or accidental.....?

Only in Thailand 16 months into a pandemic and deep in failure wrt vaccinations would they be patting themselves on the back like this over 4 'candidates' that are a long long way from effective jabs into arms...  I fear a distraction that will cost many lives, instead of getting already developed, tried and tested products out there. 

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2 hours ago, nkg said:

The 1st site resembles the book of Italian War heroes - a short easy read.

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Interesting to read of the different technologies being employed.

 

Yes, we need real vaccines and we need them now, but no harm in the development of new ones: we don't really know how long covid will hang around, causing its chaos ... and we don't know how many labs around the world are currently playing around with viruses ... with an (another) accident waiting to happen ... 

 

It may be that the future of mankind will depend on virus-control ... since we do not seem to be able to stop science students stomping around in caves and other wild places, looking for interesting things to play around with, to satisfy their dream of getting published and securing a Ph. D.

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While it is a good idea to give hope, and appeal to nationalism (occasionally), leaders also need to be realistic.

 

Assuming just one of these four is effective, we're still years away from seeing a vaccine. And by then it may well be useless.

 

4 hours ago, webfact said:

The first Thai-made COVID-19 vaccine candidate to enter human trials is the NDV-HXP-S vaccine

 

https://clinicaltrials.gov/ct2/show/NCT04764422

 

Official Title:    A Phase 1/2 Randomized, Placebo-controlled, Observer-blind Trial to Assess the Safety and Immunogenicity of NDV-HXP-S Vaccine in Thailand
Actual Study Start Date  :    March 20, 2021
Estimated Primary Completion Date  :    April 2022
Estimated Study Completion Date  :    April 2023

 

 

 

Vaccinations are need NOW. Unless the pm is ready to shutter the country until one of these "homegrown" vaccines is availabe, better to expend energy now to source vaccines and save the bluster for actual accomplishments.

 

 

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8 minutes ago, Boomer6969 said:

And somehow it works..

Well, most of the time I guess, but I have lost internet and TV for many hours during the afternoon twice in the last month.  

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Developing new vaccines? Really? Where will they be manufactured? Vaccine manufacturing is at full stretch, I would suggest.

Praise the development, yes, but get your <deleted> in gear and buy, receive and distribute sufficient already available vaccines to your population. Now!

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If PM buys so called vaccine,s from other countries not make much money but if make in Thailand me and friends better off, when human trails start l thought that's what there doing now, Pfizer, Astrazeneca and the rest of them, they skipped animal trails because the results didn't turn out very well

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If you make a movie out of what they've been doing so far, what should it be called? Any recommendation for the title of the movie?

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30 minutes ago, peterpaintpot said:

The headline for this topic should have read: Thai PM Jumps the Gun, again!

Now hold on just a second, before we criticize we should at least wait for the Homegrown Vaccine Observation Committee to be formed to to tell us how these are so perfect that they're going to wait until 2024 to begin importing vaccines created elsewhere (not because the homegrown vaccines don't work or they weren't able to actually produce them, but because the demand was so high that they ran out of the 1,000 they were able to produce, which is a good thing!)

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6 minutes ago, PETERTHEEATER said:

It's  a network. You no unnerstan?

"I have a solution to the world's energy problem. But I'm having difficulty connecting the generator to my wife's lower jaw."

 

When she invites friends put this on the coffee table.

 

51Dc0u7BxcL._AC_SX425_.jpg

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5 hours ago, law ling said:

Interesting to read of the different technologies being employed.

 

Yes, we need real vaccines and we need them now, but no harm in the development of new ones: we don't really know how long covid will hang around, causing its chaos ... and we don't know how many labs around the world are currently playing around with viruses ... with an (another) accident waiting to happen ... 

 

It may be that the future of mankind will depend on virus-control ... since we do not seem to be able to stop science students stomping around in caves and other wild places, looking for interesting things to play around with, to satisfy their dream of getting published and securing a Ph. D.

Covid will be with us for life like the Flu virus with a booster after your first 2 jabs. Maybe five years down the line we will receive a yearly booster like our winter flu jab we receive in the UK. On the 19th July we will have vaccinated enough of our population to completely open everything up. Why doesn't  the Thai PM contact health agencies that are defeating the virus like the UK ? and take the advice given. Forget all this face saving nonsense or we are good at what the Thai people do, you require your population to receive 2 top vaccines everyone has had Moderna , Astra Zeneca , or J,J listen to what there top Scientists are telling you about the Chinese Vaccine that has a poor record and why the UK for instance has not exported Sinovac or the Sputnik Vaccine you must act now and purchase the best vaccines you can not go for a cheap option as most know its cheap for a reason.

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On 7/1/2021 at 3:57 AM, webfact said:

the Prime Minister has praised the Thai scientists

Well he would whatever the outcome maybe.

 

On 7/1/2021 at 3:57 AM, webfact said:

If successful, the vaccine candidate can easily be produced

''IF''  being the operative word

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Its like me praising 'Picasso's paintings' 'Gordon Ramsay's dishes' 'Einstein's science theories' stuffs I don't know <deleted> about

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On 7/1/2021 at 10:00 AM, Scott Tracy said:

Developing new vaccines? Really? Where will they be manufactured? Vaccine manufacturing is at full stretch, I would suggest.

Praise the development, yes, but get your <deleted> in gear and buy, receive and distribute sufficient already available vaccines to your population. Now!

Available where?

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